A5102744497- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Lipid metabolism and biosynthesis
- Hernia repair and management
- Diverticular Disease and Complications
- Dialysis and Renal Disease Management
- Colorectal Cancer Screening and Detection
- Uterine Myomas and Treatments
- Inflammatory Bowel Disease
- Gynecological conditions and treatments
- Peroxisome Proliferator-Activated Receptors
- Phosphodiesterase function and regulation
- Breastfeeding Practices and Influences
- Asthma and respiratory diseases
- Genetic and Kidney Cyst Diseases
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Maternal Mental Health During Pregnancy and Postpartum
- Fatty Acid Research and Health
- Pediatric Urology and Nephrology Studies
University of Oklahoma Health Sciences Center
2022-2025
Island Hospital
2023
Women’s Health Care
2023
University of Tennessee Health Science Center
2016
Alberta Health Services
2016
Due to the growing obesity epidemic in United States, it is now estimated that approximately 1/3 of all children are born obese moms. These data, coupled with data indicating associated accelerated cyst growth autosomal dominant polycystic kidney disease (ADPKD) patients, led us hypothesize maternal may influence rate progression offspring. To test this hypothesis, we induced by high fat diet (HFD) feeding orthologous Pkd1 RC/RC mouse model ADPKD and followed (PKD) offspring for up one year....
Abstract Background Lipid metabolic reprogramming is increasingly recognized as a hallmark of endocrine resistance in estrogen receptor-positive (ER+) breast cancer. In this study, we investigated alterations lipid metabolism ER + cancer cell lines with acquired to common therapies and evaluated the efficacy clinically relevant fatty acid synthase (FASN) inhibitor. Methods resistant Tamoxifen (TamR), Fulvestrant (FulvR), long-term withdrawal (EWD) were derived. Global gene expression...
To pilot a group health service delivery model, CenteringParenting, for new parents, to assess its feasibility and impact on maternal infant outcomes.Families attended six, 2-hr sessions in their child's first year of life with three seven other families. Health assessments, parent-led discussions, vaccinations occurred within the group.Demographic, breastfeeding, vaccination, psychosocial health, parenting, satisfaction data were collected compared representative cohort.Four groups ran two...
Abstract Background Lipid metabolic reprogramming is an emerging characteristic of endocrine therapy (ET) resistance in estrogen receptor-positive (ER+) breast cancer. We explored changes lipid metabolism ER+ cancer cell lines following acquired to common treatments and tested efficacy inhibitor current clinical trials. Methods derived resistant Tamoxifen (TamR), Fulvestrant (FulvR), long-term withdrawal (EWD). Parental ET cells were subjected global gene expression unbiased lipidomic...
In humans, perinatal exposure to an elevated omega-6 (n6) relative omega-3 (n3) Fatty Acid (FA) ratio is associated with the likelihood of childhood obesity. mice, we show excessive n6-FA programs neonatal Adipocyte Stem-like cells (ASCs) differentiate into adipocytes lower mitochondrial nutrient oxidation and a propensity for storage. Omega-6 FA reduced fatty acid (FAO) capacity, coinciding impaired induction beige adipocyte regulatory factors PPARγ, PGC1α, PRDM16, UCP1. ASCs from exposed...
The second messenger cAMP is produced by several different adenylyl cyclase (AC) isoforms in human airway smooth muscle (HASM). We previously defined two distinct signaling compartments these cells, one containing AC6 and another AC2 ( Naunyn‐Schmiedebergs Arch Pharmacol , 387(4):329–39, 2014). hypothesized that phosphodiesterase (PDE) isozymes may also be compartmentized HASM. detected mRNA protein expression of the IBMX‐insensitive PDE8A cultured HASM cells. Using lentiviral delivery shRNA...
BACKGROUND: Congenital müllerian anomalies are found in 8.0% of women with infertility and up to 5.5% a general population. Cervical diverticulum is type cervical malformation that can be congenital or acquired, only select cases documented the literature. asymptomatic present abnormal uterine bleeding, pelvic pain, infertility. Previously described management options largely limited observation exploratory laparotomy. CASE: A 35-year-old woman, gravida 2 para 2, presented persistent...