A5009181821- Adipose Tissue and Metabolism
- Fatty Acid Research and Health
- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
- Animal Ecology and Behavior Studies
- Liver Disease Diagnosis and Treatment
- Insect and Pesticide Research
- Adipokines, Inflammation, and Metabolic Diseases
- Forest Insect Ecology and Management
- Forensic Entomology and Diptera Studies
- Glaucoma and retinal disorders
- Peroxisome Proliferator-Activated Receptors
- Birth, Development, and Health
- Regulation of Appetite and Obesity
- Insect-Plant Interactions and Control
- Insect Utilization and Effects
- Insect Pest Control Strategies
- Insect Resistance and Genetics
- Redox biology and oxidative stress
- Nitric Oxide and Endothelin Effects
- Biochemical Analysis and Sensing Techniques
University of Oklahoma Health Sciences Center
2021-2024
OU Health
2022
Oklahoma State University
2021-2022
Chronic inflammation is a key player in metabolic dysfunction-associated fatty liver disease (MAFLD) progression. Necroptosis, an inflammatory cell death pathway, elevated MAFLD patients and mouse models, yet its role unclear due to the diverse models inhibition strategies. In our study, we inhibited necroptosis by targeting mixed lineage kinase domain-like pseudokinase (MLKL), terminal effector of necroptosis, high-fat, high-fructose, high-cholesterol (HFHFrHC) model diet-induced MAFLD....
Establishing metabolic programming begins during fetal and postnatal development, early-life lipid exposures play a critical role neonatal adipogenesis. We define how consumption of low omega-6 to −3 fatty acid ratio (n6/n3 FA ratio) establishes oxidation in adipocyte precursor cells (APCs) before they become adipocytes. In vivo, APCs isolated from mouse pups exposed the n6/n3 had superior capacity, elevated beige mRNAs Ppargc1α, Ucp2, Runx1, increased nuclear receptor NR2F2 protein. vitro,...
ABSTRACT Chronic inflammation is a key player in metabolic dysfunction-associated fatty liver disease (MAFLD) progression. Necroptosis, an inflammatory cell death pathway, elevated MAFLD patients and mouse models, yet its role unclear due to diverse models inhibition strategies. In our study, we inhibited necroptosis by targeting mixed lineage kinase domain like pseudokinase (MLKL), the terminal effector of necroptosis, high-fat, high-fructose, high-cholesterol (HFHFrHC) model diet-induced...
The prevalence of childhood obesity has increased nearly ten times over the last 40 years, influenced by early life nutrients that have persistent effects on life-long metabolism. During first six months, infants undergo accelerated adipose accumulation, but little is known regarding infant fatty acid status and its relationship to body composition. We tested hypothesis a low arachidonic docosahexaenoic ratio (AA/DHA) in red blood cells (RBCs), long-term indicator intake, would associate...
In humans, perinatal exposure to an elevated omega-6 (n6) relative omega-3 (n3) Fatty Acid (FA) ratio is associated with the likelihood of childhood obesity. mice, we show excessive n6-FA programs neonatal Adipocyte Stem-like cells (ASCs) differentiate into adipocytes lower mitochondrial nutrient oxidation and a propensity for storage. Omega-6 FA reduced fatty acid (FAO) capacity, coinciding impaired induction beige adipocyte regulatory factors PPARγ, PGC1α, PRDM16, UCP1. ASCs from exposed...
Nicrophorus is a genus of beetles that bury and transform small vertebrate carcasses into brood ball coated with their oral anal secretions to prevent decay will serve as food source for young. pustulatus an unusual species the ability overtake other burying whose secretions, unlike species, has been reported not exhibit antimicrobial properties. This work aims better understand how presence or absence influences expression genes involved in feeding process N . To achieve that, total RNA was...
The largest North American Silphidae, the burying beetle (ABB), Nicrophorus americanus Olivier, has been extirpated from ∼90% of its historic range and is federally threatened. Two distinct populations in Southern (Oklahoma Arkansas) North-Central United States (Nebraska South Dakota) persist at western edge ABB's former range. In Nebraska, limits occurrence are associated with Merritt Reservoir linked irrigation canals. ABBs also found nearby hand-planted McKelvie National Forest. While...
During the last century, range of American burying beetle (Nicrophorus americanus Olivier) has been reduced by >90%. Only isolated, extant populations this federally threatened species now exist, primarily in Great Plains. Although primary reason for decline remains unclear, anthropogenic changes to habitat and vertebrate food sources used reproduction have played a significant role. Other factors may be contributing decline, but little research conducted on understanding predators N. how...
ABSTRACT World-wide, nearly 40% of the adult population is classified as clinically obese. Central inflammation highly correlated with obesity and increases morbidity deterioration health. The hypothalamus a brain region that governs many facets energy homeostasis, melanocortins in both decrease feeding increase metabolism via melanocortin-4 receptors (MC4Rs). Although MC4Rs are present on neurons astrocytes (aMC4R) previous work has focused almost exclusively neuronal contribution aMC4R...