A5087813317- Chemical Synthesis and Analysis
- Cyclopropane Reaction Mechanisms
- Cancer-related gene regulation
- Calcium signaling and nucleotide metabolism
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Reactivity of Heterocycles
- Asymmetric Synthesis and Catalysis
- Epigenetics and DNA Methylation
- Synthetic Organic Chemistry Methods
- Mass Spectrometry Techniques and Applications
- Fluorine in Organic Chemistry
- Crystallography and molecular interactions
- Piperaceae Chemical and Biological Studies
- Oxidative Organic Chemistry Reactions
- Synthesis and Characterization of Pyrroles
- Catalytic C–H Functionalization Methods
- Ion Channels and Receptors
- Analytical Chemistry and Chromatography
- Molecular Sensors and Ion Detection
- Photoreceptor and optogenetics research
- Carbohydrate Chemistry and Synthesis
- Adenosine and Purinergic Signaling
- Innovative Microfluidic and Catalytic Techniques Innovation
- Biochemical and Molecular Research
University of Nottingham
2011-2022
University of Bath
2001-2009
University of Edinburgh
1998-1999
University of Southampton
1996-1999
University of Sheffield
1993
The nucleotide NAADP was recently discovered as a second messenger involved in the initiation and propagation of Ca(2+) signaling lymphoma T cells, but its impact on primary cell function is still unknown. An optimized, synthetic, small molecule inhibitor action, termed BZ194, designed synthesized. BZ194 neither interfered with mobilization by d-myo-inositol 1,4,5-trisphosphate or cyclic ADP-ribose nor capacitative entry. specifically effectively blocked NAADP-stimulated [(3)H]ryanodine...
Abstract Commercially available iron(III) and copper(I) complexes catalyzed multicomponent cycloaddition reactions between diazo compounds, pyridines, electrophilic alkenes to give alkaloid‐inspired tetrahydroindolizidines in high yield with diastereoselectivity. Hitherto, the catalytic formation of versatile pyridinium ylides from metal carbenes has been poorly developed; broad utility demonstrated herein sets stage for invention further future.
The iron(III)-catalyzed synthesis of indolizines from commercially available alkyne, pyridine, and diazo precursors is reported. This mild, expedient method tolerant various solvents proceeds with as little 0.25 mol % [Fe(TPP)Cl]. Significantly, this multicomponent reaction compatible electrophilic alkynes; control experiments demonstrate the importance catalyst in promoting pyridinium ylide formation over background reactivity.
Polystyrene-supported ruthenium complex 8 is a robust pro-catalyst for olefin metathesis that can be used in non-degassed solvents and recycled without added stabilisers.
As a result of chemical genetic screen for modulators metalloprotease activity, we report that 2-mercaptopyridine-N-oxide induces conspicuous undulating notochord defect in zebrafish embryos, phenocopy the leviathan mutant. The location chemically-induced wavy correlated with timing application, thus defining narrow sensitivity window during segmentation stages. Microscopic observations revealed undulations appeared phase cell vacuolation and elongation. Notochord cells become swollen as...
Cycloaddition reactions between pyridinium ylides and 3-alkenyl oxindoles that proceed in high yield with very good regio- diastereoselectivity are reported. The resulting cycloadducts have the same stereochemistry of biologically active oxindole alkaloids, such as strychnofoline.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChiral bisfunctionalization of substrates: a powerful strategy for the asymmetric synthesis C2 symmetric compounds and its application to enantiomerically pure trans-1,3-dithiane 1,3-dioxideVarinder K. Aggarwal, Graham Evans, Eduardo Moya, James DowdenCite this: J. Org. Chem. 1992, 57, 24, 6390–6391Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November...
The GLUT5 transporter catalyses the specific uptake of D-fructose and can accept this hexose in its furanose pyranose ring forms. does not fructose epimers has very limited tolerance bulky groups substituted at 2-, 3-, 4- 5-OH positions [Tatibouët, Yang, Morin Holman (2000) Bioorg. Med. Chem. 8, 1825-1833]. To further explore whether be tolerated primary OH positions, a analogue with an allylamine group substitution to replace 1-OH was synthesized found quite well ( K (i)=27.1 mM). However,...
Protein arginine N-methyltransferases (PRMTs) selectively replace N–H for N–CH3 at substrate protein guanidines, a post-translational modification important range of biological processes, such as epigenetic regulation, signal transduction and cancer progression. Selective chemical probes are required to establish the dynamic function individual PRMTs. Herein, model inhibitors designed occupy PRMT binding sites an S-adenosylmethionine (AdoMet) co-factor described. Expedient access compounds...
In this review, we consider green chemistry metrics, related software tools, and the opportunities challenges for their use in research laboratories. We provide an overview of state-of-the-art designed both to aid researchers planning conducting chemical experiments assess sustainability individual reactions synthetic routes. The increasing digitalisation means that there is great opportunity more extensive computational tools by chemists closer integration principles into routine work...
Abstract Commercially available iron(III) and copper(I) complexes catalyzed multicomponent cycloaddition reactions between diazo compounds, pyridines, electrophilic alkenes to give alkaloid‐inspired tetrahydroindolizidines in high yield with diastereoselectivity. Hitherto, the catalytic formation of versatile pyridinium ylides from metal carbenes has been poorly developed; broad utility demonstrated herein sets stage for invention further future.
Attenuating the function of protein arginine methyltransferases (PRMTs) is an objective for investigation and treatment several diseases including cardiovascular disease cancer. Bisubstrate inhibitors that simultaneously target binding sites substrate cofactor (S-adenosylmethionine (SAM)) have potential utility, but structural information on their required development. Evaluation bisubstrate featuring isosteric guanidine replacement with two prominent enzymes PRMT1 CARM1 (PRMT4) by...
In contrast to the ground state, calculation of infrared (IR) spectroscopy molecular singlet excited states represents a substantial challenge. Here, we use structural IR fingerprint range coumarin dyes assess accuracy density functional theory based methods for state spectroscopy. It is shown that Kohn-Sham provides high level and an alternative approach time-dependent simulating states.
Signaling dinucleotides: The first single-isomer synthesis of nicotinamide adenine dinucleotide phosphate (NADP) is reported. Installation and maintenance sensitive pyridinium functionalities were key to success. Significantly, conversion NADP into the important mammalian second messenger NAADP was achieved. graph shows biological evaluation activity release Ca2+ ions, which confirms identity NAADP.
Synthetic receptors for peptides and amino acid derivatives are of considerable interest because their direct relevance to many biological peptide–protein complexes, may also lead, example, new biosensors, therapeutics catalysts peptide hydrolysis. Macrocycle 1 is a selective receptor various dipeptide in chloroform, most notably shows strong preference N-Cbz-β-alanyl acids over lactic acids.
J. Dowden, D. Kilburn and P. Wright, Contemp. Org. Synth., 1995, 2, 289 DOI: 10.1039/CO9950200289