A5100335249- Renal and related cancers
- Genetic and Kidney Cyst Diseases
- Protein Kinase Regulation and GTPase Signaling
- Estrogen and related hormone effects
- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
- Renal cell carcinoma treatment
- Connective tissue disorders research
- Ion Channels and Receptors
- Urological Disorders and Treatments
- Fibroblast Growth Factor Research
- Cancer-related molecular mechanisms research
- Ion Transport and Channel Regulation
- Cancer Cells and Metastasis
- Renal Diseases and Glomerulopathies
- Pancreatic function and diabetes
- Calcium signaling and nucleotide metabolism
- Epigenetics and DNA Methylation
- Digestive system and related health
- RNA modifications and cancer
- Genetic Syndromes and Imprinting
- Blood disorders and treatments
- Biomedical Research and Pathophysiology
- Microtubule and mitosis dynamics
- Adenosine and Purinergic Signaling
North Sichuan Medical University
2024
Nanchong Central Hospital
2024
Tianjin Medical University
2017-2021
Cleveland Clinic
2013-2018
Louisiana State University Health Sciences Center New Orleans
2010-2018
Army Medical University
2015
Daping Hospital
2015
Academy of Military Medical Sciences
2014
Cleveland Clinic Lerner College of Medicine
2011-2012
Fudan University Shanghai Cancer Center
2010
The nucleotide NAADP was recently discovered as a second messenger involved in the initiation and propagation of Ca(2+) signaling lymphoma T cells, but its impact on primary cell function is still unknown. An optimized, synthetic, small molecule inhibitor action, termed BZ194, designed synthesized. BZ194 neither interfered with mobilization by d-myo-inositol 1,4,5-trisphosphate or cyclic ADP-ribose nor capacitative entry. specifically effectively blocked NAADP-stimulated [(3)H]ryanodine...
Estrogen receptors ERα and ERβ share considerable sequence homology yet exert opposite effects on breast cancer cell proliferation. While the proliferative role of in tumors is well characterized, it not clear whether antitumor activity can be mobilized cells. Here, we have shown that phosphorylation a tyrosine residue (Y36) present ERβ, but ERα, dictates ERβ-specific activation transcription required for ERβ-dependent inhibition growth culture murine xenografts. Additionally, c-ABL kinase...
Podocytes are highly specialized cells in the vertebrate kidney. They participate formation of size-exclusion barrier glomerulus/glomus and recruit mesangial endothelial to form a mature glomerulus. At least six transcription factors (wt1, foxc2, hey1, tcf21, lmx1b mafb) known be involved podocyte specification, but how they interact drive differentiation program is unknown. The Xenopus pronephros was used as paradigm address this question. All were systematically eliminated by antisense...
The formation of the vertebrate kidney is tightly regulated and relies on multiple evolutionarily conserved inductive events. These are present in complex metanephric higher vertebrates, but also more primitive pronephric functional larval stages amphibians fish. Wnts have long been viewed as central this process. Canonical β-Catenin-dependent Wnt signaling establishes progenitors non-canonical β-Catenin-independent participate morphogenetic processes that form highly sophisticated nephron...
The development of the kidney relies on establishment and maintenance a precise tubular diameter its functional units, nephrons. This process is disrupted in polycystic disease (PKD), resulting dilations nephron renal cyst formation. In course exploring G-protein-coupled signaling Xenopus pronephric kidney, we discovered that loss G-protein α subunit, Gnas, results PKD phenotype. Polycystin 1, one genes mutated human PKD, encodes protein resembling receptor. Furthermore, deletion...
Heterotrimeric G proteins, which are composed of Gα and Gβγ subunits, transduce signals sensed by the coupled surface receptors. Aberrant expressions proteins have been observed in many cancer types. This study aimed to determine expression level stimulatory protein alpha S subunit (Gαs, main transcript encoded GNAS locus) its biological function renal cell carcinoma (RCC). Western blotting quantitative reverse transcription-PCR results show that Gαs dramatically increased RCC lines (ACHN,...
Apert syndrome (AS) is a type of autosomal dominant disease characterized by premature fusion the cranial sutures, severe syndactyly, and other abnormalities in internal organs. Approximately 70% AS cases are caused single mutation, S252W, fibroblast growth factor receptor 2 (FGFR2). Two groups have generated FGFR2 knock-in mice Fgfr2S252W/+ that exhibit features AS. During present study using mouse model, an age-related phenotype bone homeostasis was discovered. The long mass lower month...
Rheumatoid arthritis (RA), a chronic autoimmune condition, is characterized by persistent synovial inflammation, bone degradation, and progressive joint deterioration. Despite considerable research efforts, the precise molecular mechanism underlying RA remains elusive. This investigation aims to elucidate potential role of N6-methyladenosine (m
<b><i>Background:</i></b> Polycystic kidney disease (PKD) represents the most prevalent inherited progressive disorder in humans. Due to complexity of genetic network behind disease, molecular mechanisms PKD are still poorly understood yet. <b><i>Objectives:</i></b> This study aimed develop a ciliogenesis-associated gene for patients and comprehensively understand underlying disease. <b><i>Method:</i></b> The potential...