A5100648250- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Lung Cancer Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- interferon and immune responses
- RNA modifications and cancer
- Tissue Engineering and Regenerative Medicine
- Advanced biosensing and bioanalysis techniques
- 3D Printing in Biomedical Research
- Radiomics and Machine Learning in Medical Imaging
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Urological Disorders and Treatments
- Bone Tissue Engineering Materials
- Lanthanide and Transition Metal Complexes
- Plant-Microbe Interactions and Immunity
- Ion Transport and Channel Regulation
- Calcium signaling and nucleotide metabolism
- RNA Interference and Gene Delivery
- Esophageal Cancer Research and Treatment
- Systemic Lupus Erythematosus Research
- Acoustic Wave Resonator Technologies
- Melanoma and MAPK Pathways
- Protein Interaction Studies and Fluorescence Analysis
Yale University
2022-2025
Second Affiliated Hospital of Nanjing Medical University
2025
Hanzhong Central Hospital
2020-2024
Nanjing University of Chinese Medicine
2022-2024
Beihua University
2023
Chinese Academy of Agricultural Sciences
2023
Institute of Plant Protection
2023
Nankai University
2020-2023
Children's Hospital of Fudan University
2021-2023
Air Force Medical University
2023
Abstract Mitogen-activated protein kinase (MPK) cascades play vital roles in plant innate immunity, growth, and development. Here, we report that the rice (Oryza sativa) transcription factor gene OsWRKY31 is a key component MPK signaling pathway involved disease resistance rice. We found activation of OsMKK10-2 enhances against blast pathogen Magnaporthe oryzae suppresses growth through an increase jasmonic acid salicylic accumulation decrease indole-3-acetic levels. Knockout compromises...
Hepatitis B virus (HBV) infection could cause hepatitis, liver cirrhosis, and hepatocellular carcinoma. HBV-mediated pathogenesis is only partially understood, but X protein (HBx) reportedly possesses oncogenic potential. Exosomes are small membrane vesicles with diverse functions released by various cells including hepatocytes, HBV harnesses cellular exosome biogenesis export machineries for virion morphogenesis secretion. Therefore, might changes in contents functional implications both...
Aquaporin-9 (AQP9) is an aquaglyceroporin strongly expressed in the basolateral membrane of hepatocytes facing sinusoids. AQP9 permeable to hydrogen peroxide (H2O2) and glycerol as well water. Here, we report impaired liver regeneration AQP9−/− mice which involves altered steady-state H2O2 concentration glucose metabolism hepatocytes. showed remarkably delayed increased mortality following 70% or 90% partial hepatectomy. Compared AQP9+/+ littermates, significantly greater hepatic more severe...
Copolymer micelles function as pH-responsive nanocarriers to enhance the cytotoxicity of a HER2 aptamer in HER2-positive breast cancer cells Yinxing Shen,1,2,* Junqi Zhang,2,* Weiju Hao,1 Tong Wang,1 Jing Liu,2 Youhua Xie,2 Shouhong Xu,1 Honglai Liu1 1State Key Laboratory for Advanced Materials, School Chemistry and Molecular Engineering, East China University Science Technology, 2Department Medical Microbiology Parasitology, Virology MOE/MOH, Basic Sciences, Fudan University, Shanghai,...
Background Chronic allograft dysfunction (CAD) stands as a critical factor that limits the long-term viability of transplanted kidneys. Ferroptosis is an iron-dependent form programmed cell death increasingly linked to chronic fibrosis. However, mechanism by which ferroptosis contributes onset and progression CAD remains unclear. Methods This study analyzed transcriptome data from renal transplant biopsy samples in Gene Expression Omnibus (GEO), through clinical samples, animal models,...
A tungsten (W) and cobalt (Co) bearing high‐alloy piercing‐plug steel is designed to improve the service life by employing a two‐stage oxidation–reduction surface treatment process under C 2 H 5 OH–H O atmosphere. Morphology, chemical composition, phase constituents of oxide scale are studied using scanning electron spectroscope, energy‐dispersive X‐ray spectroscopy, diffraction, while microstructure hardness distribution decarbonizing layer with optical microscope microhardness tester. It...
Physical forces are prominent during tumor progression. However, it is still unclear how they impact and drive the diverse phenotypes found in cancer. Here, we apply an integrative approach to investigate of compression on melanoma cells. We bioinformatics screen for most significant compression-induced transcriptomic changes phenotypic responses. show that associated with both improvement worsening patient prognoses. Phenotypically, volumetric inhibits cell proliferation migration. It also...
The purpose of this study was to evaluate the efficacy and safety BAL in treating MPP.From January 2013 2019, 1,689 pediatric patients with MPP were analyzed retrospectively. Patients subdivided into group non-BAL according whether they received treatment within seven days after admission. propensity score matching method matched patients' baseline characteristics (1:1). primary outcomes hospital stays cure rate. Secondary included mortality, co-infection, repeat hospitalization 30 days,...
T cell homeostasis is critical for the proper function of immune system. Following sharp expansion upon pathogen infection, most cells die in order to keep balance system, a process which controlled by death receptors during early phase and Bcl-2 proteins later phase. It still highly debated whether apoptosis determined from beginning, activation, or contraction. MCL1, family member, plays pivotal role survival. As fast turnover protein, MCL1 levels are tightly regulated 26S...
Primary duck hepatocytes (PDH) displays differential susceptibility to hepatitis B virus when maintained in the media supplemented with fetal bovine serum or dimethyl sulfoxide (DMSO) which has been widely used for maintenance of hepatocytes, and prolonging hepadnavirus. However mechanism underlying hepadnavirus by DMSO treatment remains unclear. In this study, a global transcriptome analysis PDHs under different culture conditions was conducted investigating effects on PDH DHBV vitro. The...
Abstract Background Mecapegfilgrastim, a long‐acting granulocyte‐colony stimulating factor has been approved for reducing the incidence of infection, particularly febrile neutropenia (FN), in China. Objective We conducted multicenter prospective observational study to examine safety and effectiveness mecapegfilgrastim preventing gastrointestinal patients receiving chemotherapy, including S‐1/capecitabine‐based regimens or fluorouracil, leucovorin, oxaliplatin, irinotecan...
Abstract Background Shigella is a major pathogen responsible for bacillary dysentery, severe form of shigellosis. Severity the disease depends on virulence infecting strain. pathogenicity multi-gene phenomenon, involving participation genes an unstable large plasmid and chromosomal islands. Results A multiplex PCR (mPCR) assay was developed to detect S. flexneri 2a from rural regions Zhengding (Hebei Province, China). We isolated tested 86 strains using our mPCR assay, which targeted ipaH ,...
The maize anthracnose stalk rot and leaf blight diseases caused by the fungal pathogen Colletotrichum graminicola is emerging as an important threat to corn production worldwide. In this work, we provide improved genome assembly of a C. strain (TZ-3) using PacBio Sequel II Illumina high-throughput sequencing technologies. TZ-3 consists 36 contigs with length 59.3 Mb. After correction evaluation data BUSCO, showed high quality integrity. Gene annotation predicted 11,911 protein-coding genes,...