A5103038747- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Electrical and Bioimpedance Tomography
- Ultrasound and Hyperthermia Applications
- Neurological disorders and treatments
- Photoacoustic and Ultrasonic Imaging
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Nanopore and Nanochannel Transport Studies
- Hepatitis C virus research
- Bacteriophages and microbial interactions
- MicroRNA in disease regulation
- Healthcare and Venom Research
- Hepatitis B Virus Studies
- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Studies
- Acupuncture Treatment Research Studies
Guiyang Medical University
2023-2024
Tianjin Medical University
2019-2020
Tianjin University
2013-2020
Shanghai Medical College of Fudan University
2014-2017
Shanghai Municipal Center For Disease Control Prevention
2014-2017
Hepatitis B virus (HBV) infection could cause hepatitis, liver cirrhosis, and hepatocellular carcinoma. HBV-mediated pathogenesis is only partially understood, but X protein (HBx) reportedly possesses oncogenic potential. Exosomes are small membrane vesicles with diverse functions released by various cells including hepatocytes, HBV harnesses cellular exosome biogenesis export machineries for virion morphogenesis secretion. Therefore, might changes in contents functional implications both...
Objective.Transcranial temporally interfering stimulation (tTIS) is a noninvasive neuromodulation method, which has been reported to be able affect the activity of small neuronal populations. To pinpoint smaller regions brain, multi-channel tTIS strategy proposed with larger numbers electrodes and multiple sets fields.Approach.First, computational model adopted prove concept theoretically. Besides, animal experiments are implemented activate motor cortex neurons in living mice different...
Conventional noninvasive electroencephalogram (EEG) is limited to poor spatial resolution due volume conduction effect. To overcome this limitation, the acoustoelectric effect (AE) based brain imaging (ABI) proposed for mapping electrical activity in a high temporal and resolution. Through phantom vivo rat experiments, study investigated biological current source coding mechanism with pulse focused ultrasound (PFU) at repetition frequency (PRF). First, deduced theory. Then, experiment,...
Conventional noninvasive electroencephalogram (EEG) suffers from poor spatial resolution due to the effect of volume conductor. Based on acoustoelectric (AE) effect, brain imaging (ABI) is a novel neuroimaging technique for mapping electrical activity, which potential high in both space and time domains. This study proposes source signal modulation mechanism with pulse focused ultrasound (pFU) ABI. First, spectral analysis AE implemented at different repetition frequencies (PRF), including...
Temporally interfering (TI) deep brain stimulation is an exciting neuromodulation technique, which can noninvasively drive neural activity in region. In this paper, two typical electrode configurations, opposite and cross, are modeled and, along different directions, the resulting distributions of envelope modulation amplitude analyzed. 3D model, pairs set x-y plane. First, one-layer four-layer tissue structures tested. Compared to one-layer, for structure, cerebrospinal fluid with higher...
To explore the mechanism of TLR4/NF-κB regulation microglia-mediated inflammation after NSC-Exos transplantation. In this study, a right middle cerebral artery occlusion model (MCAO) was constructed in SD rats, injected into lateral ventricle through brain stereo localization. TAK-242 given 1 day before MCAO rats. Histopathological changes, inflammatory factor, colocalized number CD86/Iba1 and CD206/Iba1 cells, were detected After injury, cells increased, expression pro-inflammatory factors,...