A5071929786- Alkaline Phosphatase Research Studies
- Pharmaceutical studies and practices
- S100 Proteins and Annexins
- Protease and Inhibitor Mechanisms
- Bone Metabolism and Diseases
- Bone and Dental Protein Studies
- Influenza Virus Research Studies
- Erythrocyte Function and Pathophysiology
- Medication Adherence and Compliance
- Epilepsy research and treatment
- Vaccine Coverage and Hesitancy
- Pharmacological Effects and Toxicity Studies
- Vitamin D Research Studies
- Antibiotic Use and Resistance
- Selenium in Biological Systems
- Pharmaceutical Practices and Patient Outcomes
- Lipid Membrane Structure and Behavior
- Atrial Fibrillation Management and Outcomes
- Healthcare Operations and Scheduling Optimization
- Machine Learning and Algorithms
- Bone and Joint Diseases
- semigroups and automata theory
- Health Literacy and Information Accessibility
- Telemedicine and Telehealth Implementation
- Urinary Bladder and Prostate Research
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
2003-2015
Polish Academy of Sciences
2006-2011
University of Warsaw
2010
UCB Pharma (Belgium)
2010
Université Claude Bernard Lyon 1
2008
Medical University of Warsaw
2003
In bone, mineralization is tightly regulated by osteoblasts and hypertrophic chondrocytes which release matrix vesicles (MVs) control extracellular ionic conditions composition. MVs are the initial sites of hydroxyapatite (HA) mineral formation. Despite growing knowledge about their morphology function, biogenesis not well understood. The purpose this work was to determine source in osteoblast lineage, Saos-2 cells, check whether originated from microvilli. Microvilli were isolated apical...
Abstract Matrix vesicles (MVs) are extracellular organelles that initiate mineral formation, accumulating inorganic phosphate (P i ) and calcium leading to the formation of hydroxyapatite (HA) crystals, main component bones. MVs produced during bone as well endochondral calcification cartilage. released into matrix from osseous cells such osteoblasts hypertrophic chondrocytes. In this report, using 1‐D SDS‐PAGE, in‐gel tryptic digestion an LC‐MS‐MS/MS protein identification protocol, we...
Inorganic pyrophosphate is a potent inhibitor of bone mineralization by preventing the seeding calcium-phosphate complexes. Plasma cell membrane glycoprotein-1 and tissue nonspecific alkaline phosphatase were reported to be antagonistic regulators toward inorganic formation (by plasma glycoprotein-1) degradation phosphatase) under physiological conditions. In addition, they possess broad overlapping enzymatic functions. Therefore, we examined roles within matrix vesicles isolated from femurs...
The search for new ways to optimize the use of medications by patients has led pharmaceutical community promote idea introducing pictograms into routine practice. main intention is ease patient adherence and reduce potential risks or errors associated with medications.To evaluate a series comprehension.The study was conducted in pharmacies within European Union country that belongs professional research network. Structured interviews were used comprehension. This consisted an assessment...
Bacterial mechano-sensitive (MS) channels reside in the inner membrane and are considered to act as emergency valves whose role is lower cell turgor when bacteria enter hypo-osmotic environments. However, there emerging evidence that members of Mechano-sensitive channel Small (MscS) family play additional roles bacterial plant physiology. MscS has a large cytoplasmic C-terminal region changes its shape upon activation inactivation channel. Our pull-down co-sedimentation assays show this...
Pharmaceutical pictograms have been designed to help communicate medication instructions patients. Pictograms used within a patient counseling service can significantly improve compliance and adherence. The study aimed assess the improvement of adherence therapy with use pictogram intervention in comparison standard pharmacy practice community pharmacies.
The Adverse Event Scale in Patients With Epilepsy (aESCAPE) European study (NCT00394927) explored and analyzed adverse events (AEs) reasons for modifying treatment patients treated with newer older antiepileptic drugs (AEDs) used monotherapy or polytherapy. present analysis concerns the results of recruited Poland.Multicentre, international, observational, cross-sectional investigating AEs epilepsy (aged ≥ 4 years), on stable AED one two AED(s) 3 months, using standardized questionnaires...
A progressive hydrolysis of phospholipids was observed during the mineralization process mediated by extracellular matrix vesicles. Increasing levels different products revealed phospholipase and D activities. The importance these enzymes for lies in a high rate neutral lower degradation anionic phospholipids, which may favor mineral formation vesicular membrane breakdown necessary release deposits into matrix. In this report, we focus on phosphorylation-dependent activity initiated chicken embryo
To evaluate the practical utility of pharmaceutical pictograms in routine practice community pharmacy. The primary outcome (composite endpoint) consisted three elements: i) complete use whole package medication, ii) taking recommended dose twice a day, and iii) subjective assessment patients' perspective on medical information about antibiotic therapy obtained during pharmacy consultation measured by Net Promoter Score scale from 1 to 10 where is lowest highest possible rating.A multicenter,...
Dabigatran is a direct thrombin inhibitor used to treat cardiac arrhythmias, and rates of non-adherence dabigatran in Polish populations are high. The current study examined how pharmacist-led intervention counselling with pictogram-enhanced medication instructions, smartphone reminders, can improve adherence dabigatran.A 3-month was conducted community pharmacies Poland on 325 men women filling prescription for the first time. Participating were assigned into Control Group (n = 172...
Vitamin A (all-trans retinol) and all-trans retinoid acid (ATRA) interacted with human annexin A6 (AnxA6) as evidenced by AnxA6-induced blue shift of absorption maxima, AnxA6-Trp fluorescence quenching a resonance energy transfer from Trp residue AnxA6 to retinol. In addition, both retinoids stimulated the calcium-dependent binding liposomes, accompanied oligomerization AnxA6. Up our knowledge, it is first report supporting hypothesis direct implication in vitamin A-dependent tissue mineralization.
Mirabegron, a β3-adrenoreceptor agonist, is used to treat overactive bladder. The factors affecting persistence of mirabegron use or symptom improvement are not thoroughly known, but could be related patient characteristics. Therefore, we evaluated medication use, improvement, and quality life among Finnish users. In addition, assessed possible predictors change in these variables.Participants (52 men, 118 women) with an initial prescription were recruited nationwide from 79 pharmacies....