A5040415729- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Advanced Glycation End Products research
- Glycosylation and Glycoproteins Research
- Tissue Engineering and Regenerative Medicine
- ATP Synthase and ATPases Research
- Galectins and Cancer Biology
- Cellular Mechanics and Interactions
- Carbohydrate Chemistry and Synthesis
- Graphene and Nanomaterials Applications
- Neuroscience of respiration and sleep
- Viral Infectious Diseases and Gene Expression in Insects
- Protein purification and stability
- Biochemical effects in animals
- Bone Tissue Engineering Materials
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Cell Image Analysis Techniques
- Endoplasmic Reticulum Stress and Disease
- Lipid metabolism and biosynthesis
- S100 Proteins and Annexins
- Advanced Materials and Mechanics
- Natural Antidiabetic Agents Studies
- Toxin Mechanisms and Immunotoxins
- Chemical Reactions and Isotopes
Korea Advanced Institute of Science and Technology
2020-2024
Korea Institute of Brain Science
2020-2021
Cancer secretome is a reservoir for aberrant glycosylation. How therapies alter this post- translational cancer hallmark and the consequences thereof remain elusive. Here, we show that an elevated fucosylation pan-cancer signature of both response resistance to multiple targeted therapies. Large-scale pharmacogenomics revealed genes display widespread association with these In cell cultures, xenograft mouse models, patients, kinase inhibitors distinctively induced core secreted proteins less...
Abstract Collagen is a prominent target of nonenzymatic glycation, which hallmark aging and causes functional alteration the matrix. Here, we uncover glycation‐mediated structural changes in collagen‐enriched meningeal membrane human mouse brain. Using an vitro culture platform mimicking composed fibrillar collagen, showed that accumulation advanced glycation end products (AGEs) collagen responsible for matrix remodeling. These influence fibroblast‐matrix interactions, inducing cell‐mediated...
Human iPSC-derived mesenchymal stem cells (iMSCs) are an alternative to primary (MSCs), which have been a limited supply, and attracted great deal of interest as promising cell source in cell-based therapy. However, despite their enormous therapeutic potential, it has difficult translate this potential into clinical applications due the short viability duration transplanted iMSCs. Therefore, maximize effects iMSCs, is extremely important extend retention rate during even after...
Biological systems are composed of hierarchical structures made a large number proteins. These highly sophisticated and challenging to replicate using artificial synthesis methods. To exploit these in materials science, biotemplating is used achieve biocomposites that accurately mimic biological impart functionality inorganic materials, including electrical conductivity. However, the scaffolds previous studies limited stereotypical simple morphologies with little synthetic diversity because...
Advanced glycation end products (AGEs) play a significant role in the aging processes, further regarding as hallmark of aging. Despite importance, lack monitoring tools has hampered study relationship between AGEs and Here, we firstly report novel AGEs-selective probe, AGO. AGO presented its ability to detect more sensitively than conventional approach measuring autofluorescence from AGEs. In addition, confirmed that can depending on kinetics, reflecting by preference ribose-derived Finally,...
A novel fluorescent probe, AGO, systematically detects advanced glycation end products involved in aging.
Phenotypic heterogeneity of glioblastomas is a leading determinant therapeutic resistance and treatment failure. However, functional assessment the lacking. We developed self-assembly-based system that predicts inter/intracellular phenotype associations, such as cell proliferation, invasiveness, drug responses, gene expression profiles. Under physical constraints for cellular interactions, mixed populations glioblastoma cells are sorted to form segregated architecture, depending on their...
Cell-generated mechanical forces drive many cellular and tissue-level movements rearrangements required for the tissue or organ to develop its shape1, 2, 3, 4, 5. The prevalent view of morphogenesis relies on epithelial folding resulting in compressed monolayers, overlooking involvement stroma morphogenesis1, 6, 7. Here, we report a giant web-like network formation stromal cells epithelium-stroma interface, from multi-scale mechano-reciprocity between migrating their extracellular...
Abstract Cancer secretome is a reservoir for aberrant glycosylation. How therapies alter this post-translational cancer hallmark and the consequences thereof remain elusive. Here we show that an elevated fucosylation pan-cancer signature of both response resistance to multiple targeted therapies. Large-scale pharmacogenomics revealed genes display widespread association with these In cell cultures patients, kinase inhibitors distinctively induced core secreted proteins less than 60 kDa....