A5021982717- Advanced Fluorescence Microscopy Techniques
- Advanced Optical Sensing Technologies
- Optical Coherence Tomography Applications
- Chemical Synthesis and Analysis
- Enzyme Catalysis and Immobilization
- Mechanical and Optical Resonators
- Innovative Microfluidic and Catalytic Techniques Innovation
- Synthesis and Biological Evaluation
- Steroid Chemistry and Biochemistry
- Spectroscopy and Laser Applications
- Photonic and Optical Devices
- Quantum Information and Cryptography
- Advanced Battery Technologies Research
- Algal biology and biofuel production
- Polymer Surface Interaction Studies
- Proteins in Food Systems
- Synthesis of β-Lactam Compounds
- CCD and CMOS Imaging Sensors
- Enzyme Production and Characterization
- Plant biochemistry and biosynthesis
- Cancer therapeutics and mechanisms
- Semiconductor Lasers and Optical Devices
- Chronic Lymphocytic Leukemia Research
- Advanced Fiber Laser Technologies
- Astrophysics and Cosmic Phenomena
École Polytechnique Fédérale de Lausanne
2023-2025
Istituto Nazionale di Fisica Nucleare, Sezione di Padova
2023
Universidad Complutense de Madrid
2023
Institute for High Energy Physics
2023
Universitat Politècnica de Catalunya
2023
University of Geneva
2023
Istituto Nazionale di Fisica Nucleare, Sezione di Torino
2023
Colorado State University
2002
Electrosynthesis Company (United States)
2002
Saab (Switzerland)
1996
The Hanbury Brown–Twiss (HBT) effect holds a pivotal place in intensity interferometry and gave seminal contribution to the development of quantum optics. To observe such an effect, both good spectral timing resolutions are necessary. Most often, HBT is observed for single frequency at time due its limitations dealing with multifrequencies simultaneously, halting limiting some applications. Here, we report fast data-driven spectrometer built one-dimensional array single-photon-sensitive...
The overall sensitivity of frontside-illuminated, silicon single-photon avalanche diode (SPAD) arrays has often suffered from fill factor limitations. loss can however be recovered by employing microlenses, whereby the challenges specific to SPAD are represented large pixel pitch (> 10 µm), low native (as as ∼10%), and size (up mm). In this work we report on implementation refractive microlenses means photoresist masters, used fabricate molds for imprints UV curable hybrid polymers deposited...
The Hanbury Brown-Twiss (HBT) effect holds a pivotal place in intensity interferometry and gave seminal contribution to the development of quantum optics. To observe such an effect, both good spectral timing resolutions are necessary. Most often, HBT is observed for single frequency at time, due limitations dealing with multifrequencies simultaneously, halting limiting some applications. Here, we report fast data-driven spectrometer built one-dimensional array single-photon-sensitive...
This contribution describes the operation of a pilot plant for production 3-exomethylene-7(R)-glutaroylaminocepham-4-carboxylic acid 1(S)-oxide (4a) by electrochemical reduction 3-acetoxymethyl-7(R)-glutaroylaminoceph-3-em-4-carboxylic (3a). conversion is key step in new process Ceftibuten (1). The scale-up was demonstrated using commercial flow-cell. use novel type extended-area tin cathode, which had been shown on laboratory scale to produce significant improvements process, successfully...
The latest generation of silicon photomultipliers (SiPM) offers twice as much sensitivity to Cherenkov light observed at ground level when compared photomultipliers. Their use for imaging atmospheric telescopes is increasing, from the FACT telescope, pioneer, small-sized Telescope Array (CTA) or LHAASO WFCTA camera. robustness SiPMs represents a unique opportunity ensure long-term operation with low maintenance. In this work, we present developments and performance SiPM camera aiming...
Analysis of several options for the synthesis Ceftibuten from cephalosporin C-derived starting materials led to conclusion that most practical option, leading lowest costs, would be realized by trying resurrect previously discarded electrochemical reduction process. This contribution describes preparation 3-exomethylene-7(R)-glutaroylaminocepham-4-carboxylic acid 1(S)-oxide (10,1(S)-oxide) in almost quantitative yield 3-acetoxymethyl-7(R)-glutaroylaminoceph-3-em-4-carboxylic (9,1(S)-oxide)...
In the present work, monolayer engineering was used to fabricate biocatalytic nanostructured thin films based on enzyme penicillin G acylase. The with enhanced characteristics were produced by deposition of alternate-layer assemblies a predetermined structure using combination Langmuir–Blodgett and adsorption techniques. value activity level protein detachment measured in dependence variation film composition sequence layer alternation. As result, highly active stable structures found, which...
The manufacture of low-cost, orally active cephalosporin drugs has, until now, been achieved using intermediates prepared by the ring expansion penicillin sulfoxides rather than fermented C. This report describes preparation 3-acetoxymethyl-7(R)-glutaroylaminoceph-3-em-4-carboxylic acid 1(S)-oxide (8) from C broths. new intermediate has shown (see following contributions) to be a superior starting material for low-cost cephalosporin, Ceftibuten.
Glyoxysomes isolated from maize scutella (Zea mays L.) were subjected to several disruptive treatments (osmotic shock, resuspension in an alkaline medium, addition of detergent). The damaged glyoxysomes centrifuged at 89,500g for 40 minutes and enzymic activities (isocitratase, malate synthetase, catalase, citrate dehydrogenase) measured the supernatant fraction pellet. Isocitratase is most easily released all glyoxysomal enzymes closely followed by synthetase. Citrate synthetase instances...
The foregoing papers (Bernasconi, E.; Lee, J.; Roletto, Sogli, L.; Walker, D. Org. Process Res. Dev. 2002, 6, 152 and Bernasconi, Genders, D.; Longoni, Martin, C. R.; Menon, V.; Zappi, G.; Zelenay, P.; Zhang, H. 158) describe a high-yielding, all-aqueous process for the preparation of 3-exomethylene-7(R)-glutaroylaminocepham-4-carboxylic acid 1(S)-oxide (3) from fermented cephalosporin C broth via enzyme transformations electrochemical reduction without isolation any precursors. In this...
The overall sensitivity of frontside-illuminated, silicon single-photon avalanche diode (SPAD) arrays has often suffered from fill factor limitations. loss can however be recovered by employing microlenses, whereby the challenges specific to SPAD are represented large pixel pitch (> 10 µm), low native (as as ~10%), and size (up mm). In this work we report on implementation refractive microlenses means photoresist masters, used fabricate molds for imprints UV curable hybrid polymers...
We present a single-photon-sensitive spectrometer, based on linear array of 512 single-photon avalanche diode detectors, with 0.04 nm spectral and 40 ps temporal resolutions. employ fast data-driven operation that allows direct measurement time frequency for simultaneous single photons, time- frequency-stamping each detection. Our results combine excellent resolution. benchmark our result against the Heisenberg Uncertainty Principle limit hbar/2 energy, we are only factor 10 above it,...
The overall sensitivity of frontside-illuminated, silicon single-photon avalanche diode (SPAD) arrays has often suffered from fill factor limitations. loss can however be recovered by employing microlenses, whereby the challenges specific to SPAD are represented large pixel pitch (> 10 µm), low native (as as ~10%), and size (up mm). In this work we report on implementation refractive microlenses means photoresist masters, used fabricate molds for imprints UV curable hybrid polymers...
The overall sensitivity of frontside-illuminated, silicon single-photon avalanche diode (SPAD) arrays has often suffered from fill factor limitations. loss can however be recovered by employing microlenses, whereby the challenges specific to SPAD are represented large pixel pitch (> 10 µm), low native (as as ~10%), and size (up mm). In this work we report on implementation refractive microlenses means photoresist masters, used fabricate molds for imprints UV curable hybrid polymers...
We describe a novel type of two-photon interferometer, capable spectral binning, for quantum-assisted astrometry. also demonstrated single-photon spectrometer with and timing resolutions 0.1 nm 50 ps, which can be used this purpose. This work opens new possibilities in future astronomical measurements.