A5072969767- Metal complexes synthesis and properties
- Inorganic and Organometallic Chemistry
- Connexins and lens biology
- Electrochemical Analysis and Applications
- Heat shock proteins research
- Crystal structures of chemical compounds
- Enzyme Structure and Function
- Calpain Protease Function and Regulation
- X-ray Diffraction in Crystallography
- Synthesis and Characterization of Heterocyclic Compounds
- Advanced NMR Techniques and Applications
- Protein Structure and Dynamics
- NMR spectroscopy and applications
- Synthesis and Reactivity of Heterocycles
- Crystallography and molecular interactions
- Spectroscopy and Chemometric Analyses
- Synthesis and pharmacology of benzodiazepine derivatives
- Advanced Chemical Sensor Technologies
- Hemoglobin structure and function
- Chemical Synthesis and Analysis
- Magnetism in coordination complexes
- Cultural Heritage Materials Analysis
- Retinoids in leukemia and cellular processes
- Synthesis and biological activity
- Machine Learning in Bioinformatics
University of Sassari
2002-2021
Utrecht University
1990-1993
The development and improvement of reliable computational methods designed to evaluate the quality protein models is relevant in context structure refinement, which has been recently identified as one bottlenecks limiting usefulness prediction.In this contribution, we present a method (Artificial Intelligence Decoys Evaluator: AIDE) able consistently discriminate between correct incorrect models. In particular, based on neural networks that use input 15 structural parameters, include energy,...
Thalassemias are pathologies that derive from genetic defects of the globin genes. The most common among population affect genes involved in synthesis α and β chains. main aspects these well explained a biochemical point view. diagnosis is fundamentally based on hematologic tests. A analysis particularly important to determine carriers -thalassemia, whose identification by means parameters more difficult comparison with heterozygotes for -thalassemia. This work investigates use artificial...
The shortened analogue of insulin, des‐(B26 B30)‐pentapeptide has been characterized by two‐dimensional 1H NMR. resonance assignments and the secondary structure in water solution are discussed. results indicate that is very similar to reported for crystalline state. A high flexibility both B chains observed. Of two conformations seen 2‐Zn insulin crystals indicated as molecules 1 2 (Chinese nomenclature), more molecule 1.
A pattern recognition method based on artificial neural networks (ANNs) to analyze and quantify the components of six alditol binary mixtures is presented. This suitable classify spectra 15 obtained from alditols produce quantitative estimates component concentrations. The system user-friendly helpful in solving problem greatly overlapping signals, often encountered NMR spectroscopy carbohydrates. "classification" ANN uses 200 intensity values 1H spectrum range 3.5−4 ppm. When correct...
The solution conformation of des‐(B26–B30)‐insulin (DPI) has been investigated by 1 H‐NMR spectroscopy. A set 250 approximate interproton distance restraints, derived from two‐dimensional nuclear Overhauser enhancement spectra, were used as the basis a structure determination using geometry (DG) and distance‐bound driven dynamics (DDD). Sixteen DG structures optimized energy minimization (EM) submitted to short 5‐ps restrained molecular (RMD) simulations. further refinement DDD with lowest...
Different dipeptide analogues containing an oxirane ring in the place of peptidic bond were prepared starting from naturally occurring amino acids. N-Fmoc-amino aldehydes transformed into corresponding methoxyvinyl derivatives through a Wittig reaction, and addition PhSeCl gave series different alpha-phenylselenyl aldehydes. Mukajiama reaction with silylketene acetals intermediate product that was finally desired oxiranyl peptidomimetics. Following this strategy we able to control three new...
The crystal structure of the complex [CuL][ClO4]2(L = 3-{[2-diaminomethyleneamino)thiazol-4-yl]methylsulfanyl}-N2-sulfamoylpropionamidine, famotidine) has been determined. It provides a full description metal binding sites and reveals impact co-ordination on conformation drug molecule. Even ion is not able to change some conformational features famotidine, which could be an important factor biologically. Potentiometric spectroscopic data were obtained for ternary species in...
Incubation of native, reduced Clostridium pasteurianum ferredoxin with different metals gave a range modifications in the electronic and EPR spectrum protein, or made signals disappear. The isolated after incubation under identical conditions (50 μM 1 mM metal, h incubation) was found to contain amounts foreign increasing their thiophylicity, i.e. Cd 2+ ≫ Zn > Co . Little, if any, incorporation observed for Ni , Cu Mn absence reductant. activity substituted ferredoxins hydrogenase‐coupled...
In this work the results of study on degradation dairy waste and lactose with use titanium dioxide (TiO2), as photocatalyst, are presented. The ability TiO2 to degrade is compared either in presence molecular oxygen or a bacterial hydrogenase electron acceptor. enzyme-mediated H2 production rates O2 consumption used measure donor degradation. obtained clearly indicate that can be degraded by photocatalyst. Proteins present have strong inhibitory effect process. Indeed alone easily degraded....
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon-13 NMR characterization of nickel(II)-bis(o-hydroxynaphthaldimine) complexesFranco Cariati, Maria Luisa Ganadu, Antonietta Zoroddu, Riccardo Mansani, and Rossana QuidaccioluCite this: Inorg. Chem. 1985, 24, 4030–4033Publication Date (Print):November 1, 1985Publication History Published online1 May 2002Published inissue 1 November 1985https://pubs.acs.org/doi/10.1021/ic00218a015https://doi.org/10.1021/ic00218a015research-articleACS...