A5079425398- Psoriasis: Treatment and Pathogenesis
- Infrared Thermography in Medicine
- Thermoregulation and physiological responses
- Chronic Myeloid Leukemia Treatments
- Optical Imaging and Spectroscopy Techniques
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Biosimilars and Bioanalytical Methods
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Advancements in Transdermal Drug Delivery
- Multiple Myeloma Research and Treatments
- Pharmaceutical studies and practices
- Childhood Cancer Survivors' Quality of Life
- Oral and gingival health research
- Rheumatoid Arthritis Research and Therapies
- Drug-Induced Hepatotoxicity and Protection
- Respiratory Support and Mechanisms
- Bee Products Chemical Analysis
- Health Systems, Economic Evaluations, Quality of Life
- Asthma and respiratory diseases
- Pregnancy and Medication Impact
- Pharmaceutical Practices and Patient Outcomes
Radboud University Nijmegen
1987-2024
Radboud University Medical Center
2019-2024
SickKids Foundation
2020
RELX Group (United States)
2020
The Psoriasis Area and Severity Index (PASI) score is commonly used in clinical practice research to monitor disease severity determine treatment efficacy. Automating the PASI with deep learning algorithms, like Convolutional Neural Networks (CNNs), could enable objective efficient scoring.To assess performance of image-based automated scoring anatomical regions by CNNs compare physicians.Imaging series were matched subscores determined real life treating physician. trained using...
Enabling handheld perfusion imaging would drastically improve the feasibility of in clinical practice. Therefore, we examine performance laser speckle contrast (LSCI) measurements compared to mounted measurements, demonstrated psoriatic skin. A pipeline is introduced process, analyze and compare data 11 measurement pairs (mounted-handheld LSCI modes) operated on 5 patients various skin locations. The on-surface speeds (i.e. speed light beam movements surface) are quantified employing mean...
Skin microvasculature changes are crucial in psoriasis development and correlate with perfusion. The noninvasive Handheld Perfusion Imager (HAPI) examines microvascular skin perfusion large body areas using laser speckle contrast imaging (LSCI).To (i) assess whether increased perilesional inhomogeneity predictors for expansion of lesions (ii) feasibility the HAPI system a mounted modality.In this interventional pilot study adults unstable plaque psoriasis, measurements color photographs were...
Handheld laser speckle contrast imaging (LSCI) is crucial in clinical settings, but motion artifacts (MA) can compromise perfusion image reliability. Current prevention and suppression methods are often impractical or complex. Machine vision techniques, promising medical imaging, could improve signal quality, their use suppressing MA still unexplored.
<b><i>Introduction:</i></b> Transdermal analysis patches (TAPs) noninvasively measure soluble proteins in the stratum corneum. Ultimately, such local protein profiles could benefit search for biomarkers to improve personalized treatment psoriasis. This study aimed explore patient friendliness and detection by TAP pediatric psoriasis daily clinical practice. <b><i>Methods:</i></b> In this observational study, TAPs measuring CXC chemokine ligand...
Preschool children with recurrent wheezing suffer high morbidity. It is unclear whether objective measures of asthma control, such as pulmonary function tests (PFTs), provide additional information to the clinical assessment.We recruited between 3 and 6 years old, a history in preceding year treated for acute exacerbation emergency department (ED) into an observational cohort study. Children attended two outpatient visits: first study visit within five days discharge from ED second 12 weeks...
Treatment needs of young psoriasis patients and parents are not widely studied could advance patient-centered care.To explore treatment goals preferences pediatric patients, adults, parents.A web-based survey among Dutch aged ≥6 to ≤30 years included multiple-choice, open-ended, 4-point Likert scale questions. characteristic (≤17 years) were compared adults (≥18 parents.195 (20.2 ± 6.3 45 included. The most important 'preventing lesions', 'reducing 'no itch', lesions'. Regarding...
We assessed the reliability of handheld laser speckle contrast perfusion imaging by evaluating mounted/handheld measurement pairs operated on psoriasis lesions in three steps. First, we made a denoised map per based spatial alignment raw frames and temporal averaging frames. Second, used measured on-surface speed information to compensate movement-induced extrapolation local values value corresponds zero speed. Third, compared inhomogeneity increased perilesional criteria independent...
Introduction: Skin surface proteins are potential biomarkers in psoriasis and can be measured noninvasively with the Transdermal Analysis Patch (TAP). This study aims to assess markers by TAP over time daily clinical practice, explore their correlation disease severity pediatric psoriasis, compare tape stripping detection capability. Methods: In this prospective observational practice study, patients (aged >5 <18 years) were followed during one year. At each visit, TAPs applied on...
Laser Speckle Contrast Imaging (LSCI) is an optical technique for noninvasive assessment of microcirculatory blood flow. LSCI has a broad application in medicine including dermatology. Since laser speckles are the basis this imaging modality, any external motions during measurement from both patient and operator affect flow images. This challenge called Motion Artefacts (MA). Here, we propose complete procedure analysis speckles, that is, pre-segmentation, segmentation, motion detection,...