A5100379756- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Topic Modeling
- High Altitude and Hypoxia
- RNA Interference and Gene Delivery
- Adipose Tissue and Metabolism
- Advanced Graph Neural Networks
- Ion-surface interactions and analysis
- Cancer-related gene regulation
- Semiconductor materials and devices
- Cancer Treatment and Pharmacology
- interferon and immune responses
- FOXO transcription factor regulation
- Complex Network Analysis Techniques
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- NF-κB Signaling Pathways
- PI3K/AKT/mTOR signaling in cancer
- Silicone and Siloxane Chemistry
- Hippo pathway signaling and YAP/TAZ
- Fluid Dynamics and Heat Transfer
- Sentiment Analysis and Opinion Mining
Chinese Academy of Sciences
2013-2023
Institute of Hydrobiology
2013-2023
Institute of Automation
2021-2023
Jiaxing University
2020-2021
Ministry of Agriculture and Rural Affairs
2020
University of Chinese Academy of Sciences
2020
Changchun Institute of Applied Chemistry
2014-2020
Hong Kong Polytechnic University
2019
Ningbo Institute of Industrial Technology
2018
Abstract Forkhead box O (FOXO)3, a member of the FOXO family transcription factors, plays key roles in various cellular processes, including development, longevity, reproduction, and metabolism. Recently, FOXO3 has also been shown to be involved modulating immune response. However, how regulates immunity underlying mechanisms are still largely unknown. In this study, we show that zebrafish (Danio rerio) foxo3b, an ortholog mammalian FOXO3, is induced by polyinosinic-polycytidylic acid...
Eaf factors play a crucial role in tumor suppression and embryogenesis. To investigate the potential mechanism of activity, we performed loss- gain-of-function assays zebrafish using morpholino mRNA injections, respectively. We found that eaf1 eaf2 inhibit Wnt/β-catenin signaling, thereby modulating mesodermal neural patterning embryo. Moreover, ectopic expression embryos cultured cells blocked β-catenin reporter activity. By immunoprecipitation, also observed Eaf1 Eaf2 bound to Armadillo...
// Guangqing Yu 1, 4 , Dawei Zhang 1 Wei Liu 2 Jing Wang Xing Chi Zhou Jianfang Gui and Wuhan Xiao 2, 3 State Key Laboratory of Freshwater Ecology Biotechnology, Institute Hydrobiology, Chinese Academy Sciences, Wuhan, P. R. China The Aquatic Biodiversity Conservation, Aquaculture Disease Control, Ministry Agriculture, University Beijing, Correspondence to: Xiao, email: w-xiao@ihb.ac.cn Keywords: zebrafish; androgen receptor; spermatogenesis; ovarian function Received: September 01,...
Because of the requirement oxygen (O2) to produce energy, aerobic organisms developed mechanisms protect themselves against a shortage in both acute status and chronic status. To date, how tolerate hypoxia underlying remain largely unknown. Here, we identify that Tet1, one member ten-eleven translocation (TET) family methylcytosine dioxygenases, is required for tolerance zebrafish mice. Tet1-null mice are more sensitive hypoxic conditions compared with their wild-type siblings. We...
Many aerobic organisms have developed molecular mechanism to tolerate hypoxia, but the specifics of these mechanisms remain poorly understood. It is important develop genetic methods that confer increased hypoxia tolerance intensively farmed aquatic species, as are maintained in environments with limited available oxygen. As an asparaginyl hydroxylase hypoxia-inducible factors (HIFs), factor inhibiting HIF (FIH) inhibits transcriptional activation genes by blocking association HIFs...
The essential role of pathogens in host metabolism is widely recognized, yet the mechanisms by which they affect physiology remain to be fully defined. Here, we found that NleB, an enteropathogenic Escherichia coli (EPEC) type III secretion system effector known possess N-acetylglucosamine (GlcNAc) transferase activity, GlcNAcylates HIF-1α, a master regulator cellular O2 homeostasis. We determined NleB-mediated GlcNAcylation at conserved arginine 18 (Arg18) N-terminus HIF-1α enhanced...
Protein arginine methyltransferase 5 (Prmt5), a type II methyltransferase, symmetrically dimethylates in nuclear and cytoplasmic proteins. Prmt5 is involved variety of cellular processes including ribosome biogenesis, differentiation, germ cell development, tumorigenesis. However, the mechanisms by which prmt5 influences have remained unclear. Here, loss zebrafish led to expression an infertile male phenotype due reduction number, increase apoptosis, failure gonads differentiate into normal...
Transcriptional programs regulated by the NF-κB family are essential for inflammatory response as well innate and adaptive immunity. activation occurs via two major signaling pathways: canonical noncanonical. The pathway responds to diverse immune stimulations leads rapid but transient activation. As a member of family, p65 is thought be key regulator viral infection. Because embryonic lethality p65-null mice, physiological role in antiviral still unclear. In this study, we generated...
The hypoxia-inducible factors 1α and 2α (HIF-1α HIF-2α) are master regulators of the cellular response to O2. In addition HIF-1α HIF-2α, HIF-3α is another identified member HIF-α gene family. Even though whether some isoforms have transcriptional activity or repressive still under debate, it evident that full length acts as a transcription factor. However, its function in hypoxia signaling largely unknown. Here, we showed loss hif-3α zebrafish reduced tolerance. Further assays indicated...
ZrO2 films are deposited by the electron-beam evaporation method. Parts of prepared samples posttreated with oxygen plasma at environment temperature. The laser-induced damage threshold (LIDT) increases from 15.9 to 23.1 J/cm2 after treatment plasma. Compared that as-grown samples, significant reduction average microdefect density and absorption found oxygen-plasma posttreatment. These results indicate posttreatment technique is an effective simple method for reducing improve LIDT.
Spring viremia of carp virus (SVCV) is the causative agent spring (SVC), an important infectious disease that causes high mortality in aquaculture cyprinids. How host defends against SVCV infection and underlying mechanisms are still elusive. In this study, we identify a novel gene named
Hypoxia-inducible factors are heterodimeric transcription that play a crucial role in cell's ability to adapt low oxygen. The von Hippel-Lindau tumor suppressor (pVHL) acts as master regulator of HIF activity, and its targeting prolyl hydroxylated HIF-α for proteasomal degradation under normoxia is thought be major mechanism pVHL suppression cellular response Whether regulates other targets through similar largely unknown. Here, we identify TET2/3 novel pVHL. induces TET2/3, resulting...
Patupilone, an original natural anti-cancer agent, also known as epothilone B or Epo906, has shown promise for the treatment of a variety cancers, however, systematic side effects patupilone significantly impaired its clinical translation. Herein, patupilone-loaded PLG-g-mPEG micelles were prepared. Patupilone was grafted to poly(L-glutamic acid)-graft-methoxy-poly(ethylene glycol) (PLG-g-mPEG) by Steglich esterification reaction give PLG-g-mPEG/Epo906 that could self-assemble form...
Pathological states in the early life environment of mammalian offspring, including maternal obesity and intrauterine overnutrition, can induce metabolic disorder later life. Leptin resistance caused by upregulation Socs3 hypothalamus offspring was believed to be main mechanism this effect. In study, obese mother (OM) lean (LM) models were generated feeding C57BL/6N female mice a high-fat diet or standard diet, respectively. Additionally, an with intervention (OMI) model injecting group...