A5082037730- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Spinal Cord Injury Research
- Advanced Memory and Neural Computing
- Neurological disorders and treatments
- Simulation Techniques and Applications
- Ophthalmology and Eye Disorders
- Meningioma and schwannoma management
- Vestibular and auditory disorders
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Trigeminal Neuralgia and Treatments
- Facial Nerve Paralysis Treatment and Research
- Nerve Injury and Rehabilitation
- Transcranial Magnetic Stimulation Studies
- Visual perception and processing mechanisms
- Opinion Dynamics and Social Influence
- Cardiac Arrhythmias and Treatments
- Ultrasound in Clinical Applications
- Ultrasound and Hyperthermia Applications
- Craniofacial Disorders and Treatments
- Veterinary Orthopedics and Neurology
- Systemic Sclerosis and Related Diseases
Emory University
2021-2025
The Wallace H. Coulter Department of Biomedical Engineering
2024
Georgia Institute of Technology
2024
Wright State University
2024
Los Angeles Medical Center
2019
Neurological Surgery
2019
University of California, Los Angeles
2018-2019
Ronald Reagan UCLA Medical Center
2017
Drexel University
2009
University of Rochester Medical Center
2006
Abstract Deep brain stimulation (DBS) is an effective treatment for Parkinson’s disease (PD); however, there limited understanding of which subthalamic pathways are recruited in response to stimulation. Here, by focusing on the polarity stimulus waveform (cathodic vs. anodic), our goal was elucidate biophysical mechanisms that underlie electrical human brain. In clinical studies, cathodic more easily triggers behavioral responses, but anodic DBS broadens therapeutic window. This suggests...
The combined effects of cervical electrical stimulation alone or in combination with the monoaminergic agonist buspirone on upper limb motor function were determined six subjects complete (AIS B) injury at C5 above and more than one year from time injury. Voluntary was evaluated through measures controlled hand contraction, handgrip force production, dexterity measures, validated clinical assessment batteries. Repeated measure analysis variance used to evaluate functional metrics, EMG...
Abstract Objective. Artificial neural networks (ANNs) are state-of-the-art tools for modeling and decoding activity, but deploying them in closed-loop experiments with tight timing constraints is challenging due to their limited support existing real-time frameworks. Researchers need a platform that fully supports high-level languages running ANNs (e.g. Python Julia) while maintaining critical low-latency data acquisition processing C C++). Approach. To address these needs, we introduce the...
The translational linear vestibuloocular reflex compensates most accurately for high frequencies of head translation, with response magnitude decreasing declining stimulus frequency. However, studies the perception translation typically report robust responses even at low or during prolonged motion. This inconsistency may reflect incorporation nondirectional sensory information associated vibration and noise that accompany into motion perception. We investigated passive in humans while...
Millions of people worldwide are afflicted with paralysis from a disruption neural pathways between the brain and muscles. Because their cortical architecture is often preserved, these patients able to plan movements despite an inability execute them. In such people, machine interfaces (BMI) have great potential restore lost function through neuroprosthetic devices, circumventing dysfunctional corticospinal circuitry. These devices typically derived control signals motor cortex (M1) which...
The mammalian spinal locomotor network is composed of diverse populations interneurons that collectively orchestrate and execute a range behaviors. Despite the identification many classes constituting network, it remains unclear how network's collective activity computes modifies output on step-by-step basis. To investigate this, we analyzed lumbar interneuron population recordings multi-muscle electromyography from spinalized cats performing air stepping used artificial intelligence methods...
Deep brain stimulation (DBS) is a highly efficacious treatment for appropriately selected patients with advanced, medically refractory Parkinson's disease (PD). It severely underutilized in Black patients-constituting major gap. The source of this disparity unknown, but its identification and correction are necessary to provide equitable care.To identify sources racial DBS PD.We predicted the demographics potential candidates by synthesizing published data on PD race. We retrospectively...
To assess relationship of tremor reduction and volume lesion post Focused Ultrasound (FUS) therapy in Essential Tremor (ET) Parkinson Disease (PD) patients.
Abstract Deep brain stimulation (DBS) is an effective treatment for Parkinson’s disease (PD); however, there limited understanding of which subthalamic pathways are recruited in response to stimulation. Here, by focusing on the polarity stimulus waveform (cathodic vs. anodic), our goal was elucidate biophysical mechanisms that underlie electrical human brain. In clinical studies, cathodic more easily triggers behavioral responses, but anodic DBS broadens therapeutic window. This suggests...
In response to translations of the head, linear vestibulo‐ocular reflex (LVOR) produces compensatory eye movements that are high‐pass in nature, with a declining magnitude and an increasing phase lead stimulus frequency. Perception head translation, however, is reported be robust at much lower frequency than predicted by LVOR, causing speculation vestibular processing underlying perceptual responses different. Direct comparison these two across large range proves problematic, part because...
Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect neural function. One such mechanism called AMPAergic scaling was be likely candidate homeostatically control spiking activity. However, recent findings have forced us reconsider this idea as several studies suggest is not directly triggered by changes in spiking. Moreover, examining homeostatic perturbations vivo suggested GABAergic synapses may more critical terms homeostasis. Here, we show results...
Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect neural function. One such mechanism called AMPAergic scaling was be likely candidate homeostatically control spiking activity. However, recent findings have forced us reconsider this idea as several studies suggest is not directly triggered by changes in spiking. Moreover, examining homeostatic perturbations vivo suggested GABAergic synapses may more critical terms homeostasis. Here we show results...
Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect neural function. One such mechanism called AMPAergic scaling was be likely candidate homeostatically control spiking activity. However, recent findings have forced us reconsider this idea as several studies suggest is not directly triggered by changes in spiking. Moreover, examining homeostatic perturbations vivo suggested GABAergic synapses may more critical terms homeostasis. Here, we show results...
Abstract Spinal cord injury leads to hyperexcitability and dysfunction in spinal sensory processing. As hyperexcitable circuits can become epileptiform, we explored whether such activity emerges a thoracic (SCI) contusion model of neuropathic pain. Recordings from axons multiple below-lesion segmental dorsal roots demonstrated that SCI facilitated the emergence spontaneous ectopic burst spiking afferent axons, which were correlated across adjacent roots. Burst frequency with behavioral...
Pericytes line the microvasculature throughout body and play a key role in regulating blood flow by constricting dilating vessels. However, biophysical mechanisms through which pericytes transduce microenvironmental chemical mechanical cues to mediate vessel diameter, thereby impacting oxygen nutrient delivery, remain largely unknown. This knowledge gap is clinically relevant as numerous diseases are associated with aberrant contraction of pericytes, unusually susceptible injury. Here, we...
Abstract Objective. Current intracortical brain-computer interfaces (iBCIs) rely predominantly on threshold crossings (‘spikes’) for decoding neural activity into a control signal an external device. Spiking data can yield high accuracy online during complex behaviors; however, its dependence high-sampling-rate collection pose challenges. An alternative iBCI is the local field potential (LFP), continuous-valued that be acquired simultaneously with spiking activity. However, LFPs are seldom...