A5080988948- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Insect Pest Control Strategies
- Synthesis and Biological Evaluation
- Paraoxonase enzyme and polymorphisms
- Bioactive Compounds and Antitumor Agents
- Parasites and Host Interactions
- Toxin Mechanisms and Immunotoxins
- Cynara cardunculus studies
- Environmental and sustainability education
- Endometriosis Research and Treatment
- Infections and bacterial resistance
- Monoclonal and Polyclonal Antibodies Research
- Immunodeficiency and Autoimmune Disorders
- Garlic and Onion Studies
- Salmonella and Campylobacter epidemiology
- Water Resource Management and Quality
- Nanoparticles: synthesis and applications
- Antimicrobial Resistance in Staphylococcus
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Fungal Infections and Studies
- Autoimmune Bullous Skin Diseases
- Reproductive System and Pregnancy
- Urticaria and Related Conditions
- Vibrio bacteria research studies
Autonomous University of Campeche
2010-2023
Oklahoma State University Medical Center
2013
The Ohio State University
2013
Abstract Leishmaniasis is an infection caused by a protozoan parasite of the genus Leishmania and second most prevalent parasitic protozoal disease after malaria in world. We report vitro leishmanicidal activity on promastigote forms amazonensis cytotoxicity, using LLCMK 2 cells, glycoalkaloids from fruits Solanum lycocarpum , determined colorimetric methods. The alkaloidic extract was obtained acid‐base extraction; solamargine solasonine were isolated silica‐gel chromatography, followed...
ABSTRACT Little has been done during the past 100 years to develop new antileishmanial drugs. Most infected individuals live in poor countries and have a low cash income be attractive targets pharmaceutical corporations. Two heterosidic steroids, solamargine solasonine, initially identified as major components of Brazilian plant Solanum lycocarpum , were tested for leishmanicidal activity. Both alkaloids killed intracellular extracellular Leishmania mexicana parasites more efficiently than...
Here we studied ability of two naphthoquinones to inhibit Leishmania growth (2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone (TR 001) and 2,3-dibromo-1,4-naphthoquinone 002). TR 001 was more efficient than 002 in inducing killing promastigotes intracellular amastigotes. These values compare well those obtained with the standard first-line antileishmanial agent sodium stibogluconate (SSG). also induced significantly nitric oxide (NO) production or SSG. Taken together, these data show that could...
We have previously shown that female DBA/2 mice are significantly more resistant to Leishmania mexicana compared with males. Here, we analyzed the effect of 17beta-estradiol (E(2)) on function and cytokine production in male macrophages vitro. show E(2) increases NO parasite killing L. mexicana-infected without increasing pro-inflammatory cytokines. These data indicate may enhance leishmanicidal activity by directly regulating NO.
We recently demonstrated that 17β‐estradiol (E 2 ) enhances killing of Leishmania mexicana in macrophages from both male and female DBA/2 mouse by increasing nitric oxide (NO) production. Here, we analyzed the effect E on leishmanicidal activity cytokine production bone marrow‐derived (BMDMs) C57BL/6 mice vitro , specifically examining role phosphatidylinositol‐3‐kinase‐γ (PI3Kγ) ‐induced parasite killing. Unlike its mice, only increased which was evident a significant reduction infection...
We investigated the bacterial flora present in skin lesions of patients with chiclero's ulcer from Yucatan peninsula Mexico using conventional culture methods (11 patients), and an immunocolorimetric detection pathogenic Streptococcus pyogenes (15 patients). Prevalence bacteria isolated by was 90.9% (10/11). cultured, ulcers (60%), such as Staphylococcus aureus (20%), S. (1.6%), Pseudomonas aeruginosa Morganella morganii opportunist Klebsiella spp. (20.0%), Enterobacter Enterococcus (20%)....
Mexico's Yucatan Peninsula is an endemic area of cutaneous leishmaniasis, locally known as the chiclero's ulcer, and Mayan traditional medicine which refers to use
In this work we studied the in vitro toxicity of +/- 8-[(4-Amino-1-Methylbutyl)Amino]-6-Methoxy-4-Methyl-5-[3,4-dichlorophenoxy]quinoline (DN3-27-1) against stationary phase promastigotes Leishmania (L.) mexicana. Our results indicate that drug induces an important reduction parasite growth and killing compared to reference N-methyl meglumine (Glucantime). DN3-27-1 was not toxic Hela cells cultured vitro. This is first report describing promising potential treatment L. mexicana infections.
The presence of Vibrio cholerae non-O1 in water supplies for human consumption the city Campeche and rural locality Bécal was investigated. V. detected 5.9% samples obtained deep pools Campeche. Studies conducted neighbourhood Morelos indicated that collected harbored 31.5% 8.7% respectively. There a particular pattern distribution serotypes among different studied regions. Accordingly, serotype O14 predominated together with non-O1, O155 were preferentially founds taken from...
Abstract In previous studies, carried out in humans, we showed that females are resistant to Leishmania mexicana infection. We also 17β‐estradiol (E2) induces killing of parasites inside murine macrophages. this work, compared, for the first time, L survival male (male BMDM) and female (female bone marrow‐derived macrophages (BMDM) treated vitro with E2 or dihydrotestosterone (DHT). compared their levels nitric oxide (NO), interleukin (IL)‐6, IL‐10, IL‐12p70 tumour necrosis factor (TNF‐α)....
In this work we studied the in vitro toxicity of artemisinin and its chemical derivatives deoxoartemisinin, artemether arteether against stationary phase promastigotes Leishmania (L) mexicana. Results presented include dramatic changes parasite morphology when they were cultured presence these chemicals. These accompanied by parasite's lost mobility eventual death after four days culturing. We also observed that growth was much more effectively reduced cultures carried out either or...
Pentalinon andrieuxii Muell Arg is a Mexican-Central American plant anciently used by local people to treat cutaneous leishmaniasis. We evaluated hexane extract of the root we called PAE for its chemical content and immunochemical in vitro activity against Leishmania donovani healing experimental Kala-azar. Chemical analysis using gas chromatography coupled mass spectrometry (GC-MS) identified hexadecanoic acid, acid ethyl ester, 9, 12-octadecadienoic octadecanoic 9-octadecenoic ester...
In this work we tested both the in vitro and vivo anti-Leishmania mexicana activity of a molecule originally identified root Pentalinon andrieuxii Muell-Arg, plant that is widely used Mayan traditional medicine. The chemical name 24-methylcholesta-4-24(28)-dien-3-one, but for simplicity's sake, assigned short trivial urequinona will be throughout work. It induces necrosis apoptosis promastigotes cultured extensive ultrastructural damage amastigotes. also production Interleukin (IL)-2...