A5001840276- Plant Molecular Biology Research
- VLSI and FPGA Design Techniques
- Epigenetics and DNA Methylation
- Genomics and Phylogenetic Studies
- VLSI and Analog Circuit Testing
- Genetic Mapping and Diversity in Plants and Animals
- Low-power high-performance VLSI design
- Genomics and Chromatin Dynamics
- Plant nutrient uptake and metabolism
- Soybean genetics and cultivation
- Chromosomal and Genetic Variations
- Embedded Systems Design Techniques
- Legume Nitrogen Fixing Symbiosis
- Genetic and phenotypic traits in livestock
- 3D IC and TSV technologies
- Genetic diversity and population structure
- Interconnection Networks and Systems
- Plant Reproductive Biology
- Advancements in Photolithography Techniques
- Lipid metabolism and biosynthesis
- RNA modifications and cancer
- Plant Genetic and Mutation Studies
- Plant tissue culture and regeneration
- Evolution and Genetic Dynamics
- Nutrition, Genetics, and Disease
Technical University of Munich
2016-2025
Epigenomics (Germany)
2016-2025
Institute for Advanced Study
2015-2022
Eisenmann (Germany)
2016-2021
Leibniz-Institute for Food Systems Biology at the Technical University of Munich
2017
University of Groningen
2008-2016
Leibniz Institute of Plant Genetics and Crop Plant Research
2012
Institut de Biologie de l'École Normale Supérieure
2012
Centre National de la Recherche Scientifique
2012
University Medical Center Utrecht
2010
Loss or gain of DNA methylation can affect gene expression and is sometimes transmitted across generations. Such epigenetic alterations are thus a possible source heritable phenotypic variation in the absence sequence change. However, attempts to assess prevalence stable natural experimental populations quantify its impact on complex traits have been hampered by confounding effects polymorphisms. To overcome this problem as much possible, two parents with little differences, but contrasting...
The authors present a placement method for cell-based layout styles. It is composed of alternating and interacting global optimization partitioning steps that are followed by an the area utilization. Methods using divide-and-conquer paradigm usually lose view generating smaller subproblems. In contrast, GORDIAN maintains simultaneous treatment all cells over steps, thereby considering constraints reflect current dissection circuit. optimizations performed solving quadratic programming...
Quantifying the impact of heritable epigenetic variation on complex traits is an emerging challenge in population genetics. Here, we analyze a isogenic Arabidopsis lines that segregate experimentally induced DNA methylation changes at hundreds regions across genome. We demonstrate several these differentially methylated (DMRs) act as bona fide quantitative trait loci (QTL(epi)), accounting for 60 to 90% heritability two traits, flowering time and primary root length. These QTL(epi) are...
We present a new force directed method for global placement. Besides the well-known wire length dependent forces we use additional to reduce cell overlaps and consider placement area. Compared existing approaches, main advantage is that algorithm provides increased flexibility enables variety of demanding applications. Our capable addressing problems placement, floorplanning, timing minimization interaction logic synthesis. Among considered objective functions are area, timing, congestion...
Significance Changes in the methylation status of cytosine nucleotides are a source heritable epigenetic and phenotypic diversity plants. Here we derive robust estimates rate at which is spontaneously gained (forward epimutation) or lost (backward genome model plant Arabidopsis thaliana . We show that forward–backward dynamics selectively neutral epimutations have major impact on methylome evolution shape genome-wide patterns among natural populations this species. The epimutation rates...
Abstract Epigenetics is receiving growing attention in the plant science community. Epigenetic modifications are thought to play a particularly important role fluctuating environments. It hypothesized that epigenetics contributes phenotypic plasticity because epigenetic modifications, contrast DNA sequence variation, more likely be reversible. The population of decrease methylation 1-2 (ddm1-2)-derived recombinant inbred lines (epiRILs) Arabidopsis thaliana well suited for studying this...
Article Analytical placement: A linear or a quadratic objective function? Share on Authors: Georg Sigl Institute of Electronic Design Automation, Department Electrical Engineering, Technical University Munich, D-8000 Munich 2, Germany GermanyView Profile , Konrad Doll Frank M. Johannes Authors Info & Claims DAC '91: Proceedings the 28th ACM/IEEE Automation ConferenceJune 1991 Pages 427–432https://doi.org/10.1145/127601.127707Online:01 June 1991Publication History...
The force-directed quadratic placer ldquoKraftwerk2,rdquo as described in this paper, is based on two main concepts. First, the force that necessary to distribute modules chip separated into following components: a hold and move force. Both components are implemented systematic manner. Consequently, Kraftwerk2 converges such module overlap reduced each placement iteration. second concept of use ldquoBound2Boundrdquo net model, which accurately represents half-perimeter wirelength (HPWL) cost...
Standard cell circuits consist of millions standard cells, which have to be aligned overlap-free the rows chip. Placement these is done in consecutive steps. First, a global placement obtained by roughly spreading cells on chip, while considering all relevant objectives like wirelength, and routability. After that, legalized, i.e., overlap removed, are rows. To preserve result placement, should moved as little possible during legalization
The rate of meiotic crossing over (CO) varies considerably along chromosomes, leading to marked distortions between physical and genetic distances. causes underlying this variation are being unraveled, DNA sequence chromatin states have emerged as key factors. However, the extent which suppression COs within repeat-rich pericentromeric regions plant mammalian chromosomes results from their high level polymorphisms heterochromatic state, notably dense methylation, remains unknown. Here, we...
We extensively phenotyped 6000 Arabidopsis plants with experimentally perturbed DNA methylomes as well a diverse panel of natural accessions in common garden. found that alterations methylation not only caused heritable phenotypic diversity but also produced heritability patterns closely resembling those the accessions. Our findings indicate epigenetically induced and naturally occurring variation complex traits share part their polygenic architecture may offer complementary adaptation...
Variation in DNA methylation enables plants to inherit traits independently of changes sequence. Here, we have screened an Arabidopsis population epigenetic recombinant inbred lines (epiRILs) for resistance against Hyaloperonospora arabidopsidis (Hpa). These share the same genetic background, but show variation heritable patterns methylation. We identified four quantitative trait loci (epiQTLs) that provide without reducing plant growth or other (a)biotic stresses. Phenotypic...
Abstract Background Plants can transmit somatic mutations and epimutations to offspring, which in turn affect fitness. Knowledge of the rate at these variations arise is necessary understand how plant development contributes local adaption an ecoevolutionary context, particularly long-lived perennials. Results Here, we generate a new high-quality reference genome from oldest branch wild Populus trichocarpa tree with two dominant stems have been evolving independently for 330 years. By...
Despite the importance and wide exploitation of heterosis in commercial crop breeding, molecular mechanisms behind this phenomenon are not completely understood. Recent studies have implicated changes DNA methylation small RNAs hybrid performance; however, it remains unclear whether epigenetic a cause or consequence heterosis. Here, we analyze large panel over 500 Arabidopsis (Arabidopsis thaliana) plants (epiHybrids), which derived from near-isogenic but epigenetically divergent parents....
Molecular clocks are the basis for dating divergence between lineages over macroevolutionary timescales (~105 to 108 years). However, classical DNA-based tick too slowly inform us about recent past. Here, we demonstrate that stochastic DNA methylation changes at a subset of cytosines in plant genomes display clocklike behavior. This "epimutation clock" is orders magnitude faster than and enables phylogenetic explorations on scale years centuries. We show experimentally epimutation...