A5035806094- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Vestibular and auditory disorders
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Stroke Rehabilitation and Recovery
- Motor Control and Adaptation
- Eating Disorders and Behaviors
- Botulinum Toxin and Related Neurological Disorders
- Neurological Disorders and Treatments
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Genetic Neurodegenerative Diseases
- Neuroscience and Music Perception
- Urinary Bladder and Prostate Research
- Spinal Dysraphism and Malformations
- Intraoperative Neuromonitoring and Anesthetic Effects
- Spatial Neglect and Hemispheric Dysfunction
- Cancer-related cognitive impairment studies
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2023
Bambino Gesù Children's Hospital
2019-2023
Fondazione Santa Lucia
2012-2021
University of Brescia
2017
Policlinico Tor Vergata
2017
Brescia University
2017
University of Rome Tor Vergata
2017
Gait and balance impairment is associated with poorer functional recovery after stroke. The cerebellum known to be strongly implicated in the reorganization of motor networks patients stroke, especially for gait functions.To determine whether cerebellar intermittent θ-burst stimulation (CRB-iTBS) can improve functions hemiparesis due stroke.This randomized, double-blind, sham-controlled phase IIa trial investigated efficacy safety a 3-week treatment CRB-iTBS coupled physiotherapy promoting...
Learning of new skills may occur through Hebbian associative changes in the synaptic strength cortical connections [spike-timing-dependent plasticity (STDP)], but how precise temporal relationship presynaptic and postsynaptic inputs determines STDP effects humans is poorly understood. We used a novel paired stimulation protocol to repeatedly activate short-latency connection between posterior parietal cortex primary motor (M1) left-dominant hemisphere. In different experiments, we...
A fully adapted behavior requires maximum efficiency to inhibit processes in the motor domain [1Aron A.R. Durston S. Eagle D.M. Logan G.D. Stinear C.M. Stuphorn V. Converging evidence for a fronto-basal-ganglia network inhibitory control of action and cognition.J. Neurosci. 2007; 27: 11860-11864Crossref PubMed Scopus (403) Google Scholar]. Although number cortical subcortical brain regions have been implicated, converging suggests that activation right inferior frontal gyrus (r-IFG)...
In animal models of Alzheimer's disease (AD), amyloid-β fragments interfere with mechanisms cortical plasticity such as long-term potentiation (LTP) and depression (LTD). the current study, we applied repetitive transcranial magnetic
Paired associative stimulation (PAS) protocols induce forms of spike-timing-dependent-plasticity (STDP) when paired pulses are repeatedly applied with different timing over interconnected cortical areas such as the posterior parietal cortex (PPC) and primary motor (M1). However, assessment PAS effects is usually limited to M1 through recording motor-evoked potential (MEP) amplitude. Here, by combining transcranial magnetic (TMS) EEG we aimed at investigating both (PPC, M1) modulation induced...
To determine whether a transcranial magnetic stimulation (TMS) multiparadigm approach can be used to distinguish Alzheimer disease (AD) from frontotemporal dementia (FTD).Paired-pulse TMS was investigate short-interval intracortical inhibition (SICI) and facilitation (ICF), long-interval inhibition, short-latency afferent (SAI) measure the activity of different circuits in patients with AD, FTD, healthy controls (HC). The primary outcome measures were sensitivity specificity measures,...
Abstract Voluntary movement control and execution are regulated by the influence of cerebellar output over different interconnected cortical areas, through dentato-thalamo connections. In present study we applied transcranial magnetic stimulation (TMS) electroencephalography (EEG) to directly assess effects theta-burst (TBS) controlateral primary motor cortex (M1) posterior parietal (PPC) in a group healthy volunteers. We found TBS-dependent bidirectional modulation TMS-evoked activity;...
Alzheimer's disease (AD) is considered an age-related disorder. However, it unclear whether AD induces the same pathological and neurophysiological modifications in synaptic functions independently from age of onset. We used transcranial magnetic stimulation tools to investigate mechanisms cortical plasticity sensory-motor integration patients with a wide range onset.We evaluated newly diagnosed sporadic (n = 54) comparison healthy age-matched controls (HS; n 24). Cortical long-term...
Abstract Interhemispheric interactions in stroke patients are frequently characterized by abnormalities, terms of balance and inhibition. Previous results showed an impressive variability, mostly given to the instability motor‐evoked potentials when evoked from affected hemisphere. We aim find reliable interhemispheric measures with a not‐evocable potential hemisphere, combining transcranial magnetic stimulation (TMS) electroencephalography. Ninteen (seven females; 61.26 ± 9.8 years) were...
Levodopa-induced dyskinesias are disabling motor complications of long-term dopamine replacement in patients with Parkinson's disease. In recent years, several alternative models have been proposed to explain the pathophysiological mechanisms underlying this hyperkinetic disorder. particular, our group has shed new light on role prefrontal cortex as a key site interest, demonstrating that, among other areas, inferior frontal is particularly characterized by altered patterns anatomical and...
Objective To determine the ability of transcranial magnetic stimulation (TMS) in detecting synaptic impairment patients with Alzheimer’s disease (AD) and predicting cognitive decline since early phases disease. Methods We used TMS-based parameters to evaluate long-term potentiation (LTP)-like cortical plasticity cholinergic activity as measured by short afferent inhibition (SAI) 60 newly diagnosed AD 30 healthy age-matched subjects (HS). Receiver operating characteristic (ROC) curves were...
The cerebellum is strongly implicated in learning new motor skills. Theta burst stimulation (TBS), a form of repetitive transcranial magnetic stimulation, can be used to influence cerebellar activity. Our aim was explore the potential TBS modulating visuo-motor adaptation, learning, young healthy subjects. Cerebellar applied immediately before phase adaptation task (VAT), two different experiments. Firstly, we evaluated behavioral effects continuous (cTBS), intermittent (iTBS) or sham on...
The dysfunction of cholinergic neurons is a typical hallmark in Alzheimer's disease (AD). Previous findings demonstrated that high density receptors found the thalamus and cerebellum compared with cerebral cortex hippocampus. We aimed at investigating whether activation cerebello-thalamo-cortical pathway by means cerebellar theta burst stimulation (TBS) could modulate central functions evaluated vivo using neurophysiological determination Short-Latency Afferent Inhibition (SLAI). tested SLAI...
Abstract In Alzheimer’s disease (AD) patients, apopoliprotein (APOE) polymorphism is the main genetic factor associated with more aggressive clinical course. However, interaction between cerebrospinal fluid (CSF) tau protein levels and APOE genotype has been scarcely investigated. A possible key mechanism invokes dysfunction of synaptic plasticity. We investigated how CSF interacts in AD patients. firstly explored whether influence progression long-term potentiation (LTP)-like cortical...
Background:Although motor disturbances parallel the course of dementia, worsening both quality life and social costs, pathogenesis remains still unclear. Objective:Through combination cerebrospinal fluid (CSF) biomarkers assessment transcranial magnetic stimulation (TMS) protocols , here we provided a cross-sectional study to understand pathogenic mechanisms Alzheimer's disease (AD)-related early disturbances. Methods:The phenotype, as defined with Unified Parkinson's Disease Rating Scale...
Cerebrospinal fluid (CSF) concentrations of amyloid-β (Aβ), total tau (t-tau), and phosphorylated proteins are associated with different clinical progression in Alzheimer’s disease (AD). We enrolled forty newly diagnosed AD patients, who underwent lumbar puncture, carried out a K-means cluster analysis based on CSF biomarkers levels, resulting two patient groups: Cluster 1 showed relatively high levels Aβ low tau; 2 tau. Cortical plasticity was tested using the intermittent continuous theta...
Background: Mechanisms of cortical plasticity have been recently investigated in Alzheimer’s disease (AD) patients with transcranial magnetic stimulation protocols showing a clear impairment long-term potentiation (LTP) cortical-like mechanisms. Objective: We aimed to investigate mechanisms cortico-cortical spike-timing dependent (STDP) AD investigating the connections between posterior parietal cortex (PPC) and primary motor (M1). Methods: used paired associative (cc-PAS) protocol...
<h3>Importance</h3> Impairment of dopaminergic transmission may contribute to cognitive dysfunction in Alzheimer disease (AD). <h3>Objective</h3> To investigate whether therapy with agonists affect functions patients AD. <h3>Design, Setting, and Participants</h3> This phase 2, monocentric, randomized, double-blind, placebo-controlled trial was conducted Italy. Patients mild moderate AD were enrolled between September 1, 2017, December 31, 2018. Data analyzed from July 1 2019....
Short latency afferent inhibition (SAI) is a paired-pulse transcranial magnetic stimulation (TMS) protocol that consists in the of motor evoked potentials (MEPs) by sensory impulses. SAI thought to be mediated cholinergic projections over M1 and can considered putative marker central activity. It known memory processes are regulated acetylcholine. Nonetheless, influence tasks on has not been investigated. Here we tested changes circuits healthy subjects performing computerized non-verbal...