A5064531275- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Nanoparticle-Based Drug Delivery
- Inhalation and Respiratory Drug Delivery
- Osteoarthritis Treatment and Mechanisms
- RNA Interference and Gene Delivery
- Lipid Membrane Structure and Behavior
- Microencapsulation and Drying Processes
- thermodynamics and calorimetric analyses
- Safe Handling of Antineoplastic Drugs
- Statistical Methods in Clinical Trials
- Crystallization and Solubility Studies
- Protein purification and stability
- Pharmaceutical studies and practices
- Health Systems, Economic Evaluations, Quality of Life
- 3D Printing in Biomedical Research
- Graph Theory and Algorithms
- Microfluidic and Capillary Electrophoresis Applications
- Analytical Chemistry and Chromatography
- Infrared Thermography in Medicine
- Systemic Sclerosis and Related Diseases
- Biosimilars and Bioanalytical Methods
- Celiac Disease Research and Management
- Migraine and Headache Studies
- Nanoparticles: synthesis and applications
University of Szeged
2007-2022
University of Debrecen
1994-1998
Our study aimed to develop an “ex tempore” reconstitutable, viscosity enhancer- and preservative-free meloxicam (MEL)-loaded polymeric micelle formulation, via Quality by Design (QbD) approach, exploiting the nose-to-brain pathway, as a suitable tool in treatment of neuroinflammation. The anti-neuroinflammatory effect NSAID micelles was not studied previously, therefore its investigation is promising. Critical product parameters, encapsulation efficiency (89.4%), Z-average (101.22 ± 2.8 nm)...
Abstract: Pulmonary drug delivery of ciprofloxacin hydrochloride offers effective local antibacterial activity and convenience easy application. Spray drying is a trustworthy technique for the production microparticles. Quality by design (QbD), an up-to-date regulatory-based quality management method, was used to predict final product. According QbD-based theoretical preliminary parameter ranking priority classification, dry powder inhalation formulation tests were successfully performed in...
The aim of this study was to optimize the formulation meloxicam (MEL)-containing human serum albumin (HSA) nanoparticles for nose-to-brain via a quality by design (QbD) approach. Liquid and dried formulations containing Tween 80 without surfactant were investigated. Various properties, such as Z-average, zeta potential, encapsulation efficacy (EE), conjugation MEL HSA, physical stability, in vitro dissolution, permeability, vivo plasma brain distribution characterized. From stability point...
Liposomal formulation development is a challenging process. Certain factors have critical influence on the characteristics of liposomes, and even relevant properties can vary based predefined interests research. In this paper, Quality by Design-guided Risk Assessment (RA)-based study was performed to determine Critical Material Attributes Process Parameters an “intermediate” active pharmaceutical ingredient-free liposome prepared via thin-film hydration method, collect future carrier system...
The present study aimed to develop n-propyl gallate (PG)-encapsulated liposomes through a novel direct pouring method using the quality-by-design (QbD) approach. A further aim was coat with hyaluronic acid (HA) improve stability of formulation in nasal mucosa. QbD used for determination critical quality attributes PG-loaded coated HA. optimized determined by applying Box–Behnken design investigate effect composition and process variables on particle size, polydispersity index (PDI), zeta...
The translation of nanomedicines from the lab level into marketed product faces several challenges, including characterization physicochemical properties, pharmacodynamics, pharmacokinetics, process control, biocompatibility, and nanotoxicity, scaling-up as well reproducibility. challenges nanomedicine development are in connection with different requirements patient (clinical therapeutic use), industry (production), regulatory bodies (authorization process). This paper aims at reviewing...
The requirements of a liposomal formulation vary depending on the pharmaceutical indication, target patient population, and corresponding route administration. Different preparation methods require various material attributes (MAs) (properties characteristics components) process parameters (PPs) (settings method). identification quality product profile for liposome-based formulation, critical liposomes, possible MAs PPs that may influence key vesicles facilitates research. Researchers can...
Abstract: The nasal delivery of drugs offers a great alternative route to avoid adverse events and increase patient compliance due its advantageous properties. Besides application, topical, systemic central effects are also available. Nasal powders (NPs) have better adhesion the additive polymers that may be, eg, gelling or good wettability agents; thus, their bioavailability is compared liquid formulations. Using nanoparticles, innovative more efficient products can be achieved, which lead...
This study aimed to produce thermosensitive liposomes (TSL) by applying the quality design (QbD) concept. In this paper, our research group collected and studied parameters that significantly impact of liposomal product. Thermosensitive are vesicles used as drug delivery systems release active pharmaceutical ingredient in a targeted way at ~40-42 °C, i.e., local hyperthermia. manufacture with diameter approximately 100 nm. The first TSLs were made from DPPC...
At least 17% of the population suffers from osteoarthritis (OA) in Hungary, according to European Health Interview Survey. In until now there was no OA-specific questionnaire available for lower limb, order monitor health-related quality life (HRQoL). This gap gave relevance this research. The aim study perform Hungarian cross-cultural adaptation and validation French-developed Osteoarthritis Knee Hip Quality Life (OAKHQoL) questionnaire.The five-step translation procedure original OAKHQoL...
Development of drug delivery systems for chronic disorders needs a complex thinking in order to ensure the quality product. A multidisciplinary approach pharmaceutical technology, regulatory and behavioral sciences on basis Quality by Design methodology can be proper tool this handle formulators’, patients’, also doctors’ therapy planning case ophthalmologic disorders. According present state-of-the-art”, patient perceptions are collected form “Patient Reported Outcome Measurements” during...