A5014621367- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Birth, Development, and Health
- Biomarkers in Disease Mechanisms
- Gestational Diabetes Research and Management
- Vitamin D Research Studies
- Pregnancy-related medical research
- Inflammasome and immune disorders
- Pregnancy and Medication Impact
- Nitric Oxide and Endothelin Effects
- Gout, Hyperuricemia, Uric Acid
- Cardiovascular Issues in Pregnancy
- MicroRNA in disease regulation
- COVID-19 Impact on Reproduction
- Inflammatory Biomarkers in Disease Prognosis
- Maternal and fetal healthcare
- Education Pedagogy and Practices
- Autophagy in Disease and Therapy
- Neonatal Respiratory Health Research
- Ovarian function and disorders
- Breastfeeding Practices and Influences
- Extracellular vesicles in disease
- Immune Response and Inflammation
- Calcium Carbonate Crystallization and Inhibition
- Scientific and Engineering Research Topics
Universidade Estadual Paulista (Unesp)
2015-2024
Ação Educativa
2022
Universidade Federal de Santa Catarina
2022
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2008
La Roche College
1997
Abstract IL-1alpha and IL-1beta are potent inflammatory cytokines that contribute to a number of normal physiologic processes the development diseases. Two IL-1R, type I II receptors, have been identified. This work describes derivation characterization mice deficient in expression IL-1R (IL-1RI). IL-1RI-deficient were viable fertile, but failed respond IL-1 variety assays, including IL-1-induced IL-6 E-selectin fever. Similar IL-1beta-deficient mice, had reduced acute phase response...
Preeclampsia (PE) is a specific syndrome of pregnancy, characterized by hypertension and proteinuria. This pathology associated with hyperuricemia elevated serum levels inflammatory cytokines. Uric acid crystals may activate an intracellular complex called inflammasome, which important for processing release study investigated the state monocyte activation, both endogenous stimulated monosodium urate (MSU), gene expression NLRP1 NLRP3 receptors as well their association cytokines expression....
Preeclampsia (PE) is a human pregnancy-specific syndrome with abnormal activation of cells from the innate immune system. The present study evaluated whether silibinin (SB) treatment monocytes preeclamptic women could modulate NLRP1 and NLRP3 inflammasomes as well TLR4/NF-κB pathway activation. Peripheral blood 20 normotensive (NT) pregnant women, THP-1 cell line, were cultured or without monosodium urate (MSU) SB. NLRP1, NLRP3, Caspase-1, TLR4, MyD88, NF-κB, IL-1β, IL-18, TNF-α IL-10 gene...
Pre-eclampsia (PE) is an obstetric pathology characterized by abnormal activation of the innate and adaptive immune systems dependent on imbalance T helper subsets. The present study aimed to evaluate gene protein expression type 1 (Th1)/Th2/Th17/regulatory (Treg) cell transcription factors in peripheral blood lymphocytes from pregnant women with PE employing quantitative RT-PCR flow cytometry techniques, as well cytokine profile produced these CD4+ T-cell subsets plasma PE, classified...
Preeclampsia (PE) is characterized by great endothelial dysfunction, decreased nitric oxide (NO) bioavailability, and higher levels of arginase activity. In the present study, we investigated potential modulatory effects trans-resveratrol (RSV) on dysfunction biomarkers in cells exposed to plasma from patients with PE healthy pregnant (HP) women, umbilical arteries PE. Human vein (HUVECs) were incubated pooled 10 HP or women RSV; intracellular NO total reactive oxygen species (ROS) assessed...
Preeclampsia (PE) is a pregnancy-specific disorder that affects 3–8% expecting mothers worldwide being one of the main causes maternal and fetal morbidity mortality. The search for altered circulating molecules in PE an important target to better understand pathophysiology this disease. Therefore, we evaluated Sirtuin-1 (SIRT1) concentration plasma from healthy pregnant (HP) women, gestational hypertensive women (GH), preeclampsia via enzyme-linked immunosorbent assay (ELISA). We also...
Abstract Lead (Pb) reduces NO bioavailability, impairs the antioxidant system, and increases generation of reactive oxygen species (ROS). Pb‐induced oxidative stress may be responsible for associated endothelial dysfunction. Sildenafil has shown nitric oxide (NO)‐independent action, including effects. Therefore, we examined effects sildenafil on stress, reductions dysfunction in hypertension. Wistar rats were distributed into three groups: Pb, Pb + Sham. Blood pressure endothelium‐dependent...
Introdução: A dor no período neonatal é motivo de inúmeros estudos, sendo fundamental para a sua abordagem uma avaliação criteriosa e adequada. Objetivo: Comparar as variáveis fisiológicas com comportamentais da em recém-nascido (RN) prematuro. Métodos: Estudo realizado entre fevereiro 2003 maio 2004, recém-nascidos idade gestacional (IG) abaixo 34 semanas peso nascimento menor que 1500 g, submetidos à ventilação mecânica não sedados. As estudadas foram freqüências cardíaca (FC) respiratória...
Preeclampsia (PE) is a gestational hypertensive disease characterized by endothelial dysfunction. Epigallocatechin-3-gallate (EGCG), the main compound in green tea, promising therapeutic target for disease. By activating eNOS, EGCG increased NO production and exerted an important antioxidant action, but its specific impact context of PE remains understudied. The aim this study to evaluate effects on function static shear stress vitro models PE. Endothelial cells were incubated with healthy...
Potassium channels have an important role in the vascular adaptation during pregnancy and a reduction expression of adenosine triphosphate-sensitive potassium (Katp) has been linked to preeclampsia. Activation Katp induces vasodilation; however, no previous study conducted evaluate effects inhibition these contractility preeclamptic arteries. Glibenclamide is oral antihyperglycemic agent that inhibits widely used studies.
(1) Background: The bioavailability of nitric oxide (NO) and oxidative stress are important events related to the pathophysiology preeclampsia (PE). In this present study, we aimed evaluate antioxidant effect glibenclamide (GB) on NO synthesis, stress, capacity in endothelial cells incubated with plasma from preeclamptic (PE) normotensive pregnant women (NT). (2) Methods: Human umbilical vein (HUVECs) were a pool 10 NT PE women; NO/NOx quantification ROS levels assessed by fluorescence...