A5004902772- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Melanoma and MAPK Pathways
- Biochemical and Molecular Research
- Protein Kinase Regulation and GTPase Signaling
Princess Margaret Cancer Centre
2025
McGill University
2020-2023
Abstract Plasticity of neoplasia, whereby cancer cells attain stem-cell-like properties, is required for disease progression and represents a major therapeutic challenge. We report that in breast NANOG , SNAIL NODAL transcripts manifest multiple isoforms characterized by different 5’ Untranslated Regions (5’UTRs), translation subset these stimulated under hypoxia. The accumulation the corresponding proteins induces plasticity “fate-switching” toward stem cell-like phenotypes....
Abstract Background: Head and neck squamous cell carcinomas (HNSCC) that are not driven by human papillomavirus (HPV) associated with a higher likelihood of treatment resistance recurrence compared to HPV-positive HNSCC. There currently no genomic-guided treatments for HPV-negative HNSCC, meaning patients do benefit from precision medicine approaches. Thus, it is critical understand the mechanisms underlying HNSCC progression identify molecular targets better stratify therapeutic options...
Specificity is a limiting factor when using small-molecule inhibitors to study protein kinase signalling. Since inhibitor-resistant mutants (i.e., drug-resistant alleles) remain active in the presence of inhibitor, they facilitate validation on-target effects. By combining an mutant with mass spectrometry-based phosphoproteomics, we previously devised systematic strategy for reliable identification and CSNK2 substrates. In this study, use same evaluate selectivity CX-4945, clinical stage...