A5011100851- Autophagy in Disease and Therapy
- Cellular transport and secretion
- Calcium signaling and nucleotide metabolism
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Genetics and Neurodevelopmental Disorders
- Extracellular vesicles in disease
- Retinoids in leukemia and cellular processes
- RNA and protein synthesis mechanisms
- Endoplasmic Reticulum Stress and Disease
- Biochemical and Molecular Research
- Metabolism, Diabetes, and Cancer
- CRISPR and Genetic Engineering
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Acute Lymphoblastic Leukemia research
- Circular RNAs in diseases
Jewish General Hospital
2018-2023
McGill University
2017-2023
Technical University of Munich
2017
University of Ottawa
2017
Karolinska Institutet
2017
University of Toronto
2017
University Health Network
2017
Objective— During inflammation, macrophages secrete vesicles carrying RNA, protein, and lipids as a form of extracellular communication. In the vessel wall, (EVs) have been shown to be transferred between vascular cells during atherosclerosis; however, role macrophage-derived EVs in atherogenesis is not known. Here, we hypothesize that atherogenic microRNAs (miRNAs) mediate cell–cell communication promote proinflammatory proatherogenic phenotypes recipient cells. Approach Results— We...
Abstract Plasticity of neoplasia, whereby cancer cells attain stem-cell-like properties, is required for disease progression and represents a major therapeutic challenge. We report that in breast NANOG , SNAIL NODAL transcripts manifest multiple isoforms characterized by different 5’ Untranslated Regions (5’UTRs), translation subset these stimulated under hypoxia. The accumulation the corresponding proteins induces plasticity “fate-switching” toward stem cell-like phenotypes....
The mechanisms that govern organelle adaptation and remodelling remain poorly defined. endo-lysosomal system degrades cargo from various routes, including endocytosis, phagocytosis, autophagy. For phagocytes, endosomes lysosomes (endo-lysosomes) are kingpin organelles because they essential to kill pathogens process present antigens. During phagocyte activation, endo-lysosomes undergo a morphological transformation, going collection of dozens globular structures tubular network in requires...
Dysregulation of histone modifications promotes carcinogenesis by altering transcription. Breast cancers frequently overexpress the methyltransferase EZH2, catalytic subunit Polycomb Repressor Complex 2 (PRC2). However, role EZH2 in this setting is unclear due to context-dependent functions PRC2 and heterogeneity breast cancer. Moreover, mechanisms underlying overexpression cancer are obscure. Here, using multiple models driven oncogene ErbB2, we show that tyrosine kinase c-Src links energy...
Abstract The mechanisms that govern organelle adaptation and remodeling remain poorly defined. endo-lysosomal system degrades cargo from various routes including endocytosis, phagocytosis autophagy. For phagocytes, endosomes lysosomes (endo-lysosomes) are kingpin organelles since they essential to kill pathogens process present antigens. During phagocyte activation, endo-lysosomes undergo a morphological transformation, going collection of dozens globular structures tubular network in...
Abstract Plasticity of neoplasia, whereby cancer cells attain stem-cell-like properties, is required for disease progression and represents a major therapeutic challenge. We report that in breast NANOG , SNAIL NODAL transcripts manifest multiple isoforms characterized by different 5’ Untranslated Regions (5’UTRs), translation subset these stimulated under hypoxia. This leads to accumulation corresponding proteins which induce plasticity “fate-switching” toward stem-cell like phenotypes....
<p>The mechanisms that govern organelle adaptation and remodelling remain poorly defined. The endo-lysosomal system degrades cargo from various routes, including endocytosis, phagocytosis, autophagy. For phagocytes, endosomes lysosomes (endo-lysosomes) are kingpin organelles because they essential to kill pathogens process present antigens. During phagocyte activation, endo-lysosomes undergo a morphological transformation, going collection of dozens globular structures tubular network...
<p>The mechanisms that govern organelle adaptation and remodelling remain poorly defined. The endo-lysosomal system degrades cargo from various routes, including endocytosis, phagocytosis, autophagy. For phagocytes, endosomes lysosomes (endo-lysosomes) are kingpin organelles because they essential to kill pathogens process present antigens. During phagocyte activation, endo-lysosomes undergo a morphological transformation, going collection of dozens globular structures tubular network...
The molecular mechanisms that govern and adapt the number, size, morphology activities of organelles to suit needs many cell types conditions these cells may encounter are at frontier biology. Lysosomes degrade cargo from various routes including endocytosis, phagocytosis autophagy. have also emerged as a signalling platform senses integrates stress signals such nutrient deprivation with regulatory kinase hubs like mTOR AMPK modulate metabolic activity. For phagocytes antigen‐presenting...
Abstract The molecular mechanisms that govern and adapt organelle number, size, morphology activities to suit the needs of many cell types conditions a may encounter remain poorly defined. Lysosomes are organelles degrade cargo from variety routes including endocytosis, phagocytosis autophagy. have emerged as signalling platform senses couples stress signals such nutrient deprivation regulatory kinase hubs like mTOR AMPK modulate metabolic activity. For phagocytes antigen-presenting cells...