A5100713777- Cancer-related gene regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Virus-based gene therapy research
- Circular RNAs in diseases
- Cancer Research and Treatments
- MicroRNA in disease regulation
- interferon and immune responses
- Wnt/β-catenin signaling in development and cancer
- Cancer Cells and Metastasis
- NF-κB Signaling Pathways
- Hippo pathway signaling and YAP/TAZ
- Urological Disorders and Treatments
- Ubiquitin and proteasome pathways
- Cancer, Lipids, and Metabolism
- Immune Response and Inflammation
- Aldose Reductase and Taurine
- Microbial bioremediation and biosurfactants
- Erythrocyte Function and Pathophysiology
- Plant Genetic and Mutation Studies
- Cell death mechanisms and regulation
- Bacteriophages and microbial interactions
- Cell Adhesion Molecules Research
- Peptidase Inhibition and Analysis
- Caveolin-1 and cellular processes
Third Affiliated Hospital of Harbin Medical University
2018-2023
Harbin Medical University
2016-2023
Second Affiliated Hospital of Harbin Medical University
2016-2021
Guizhou Provincial People's Hospital
2018
Wuhan University
2008-2012
Zhejiang Sci-Tech University
2010-2012
Long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) plays key role in the progression of some human cancers. However, NEAT1 laryngeal squamous cell cancer (LSCC) is still unknown. We therefore investigated expression and function LSCC. level LSCC adjacent non-neoplastic tissues were detected by qRT-PCR. was knockdown cells proliferation, apoptosis cycle examined. The growth xenografts with analyzed. significantly higher than corresponding tissues, patients neck nodal...
As a type of recently discovered noncoding RNA, circular RNAs (circRNAs) exert pivot biological functions in diverse cancers. However, the role circRNA_102171 papillary thyroid cancer (PTC) has not been investigated. Our study was focused on functional investigation toward PTC progression. And we also aimed to reveal its potential molecular mechanism.The expression pattern determined using quantitative polymerase chain reaction (qPCR) samples and cell lines. Cell proliferation examined...
// Tianyi Wu 1, * , Lingmei Qu 2, Guoqing He Linli Tian Liang Li 1 Han Zhou Qian Jin Jingyuan Ren 3 Yu Wang Jingting Xuan Kan Ming Liu Jia Shen 4 Mian Guo 5 Yanan Sun Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital Harbin Medical University, Harbin, China 2 Fifth Daqing, Oncology Jilin province, Changchun, Orthopaedic Surgery the Research Center, University California, Los Angeles, USA Neurosurgery, These authors contributed equally to this work...
The incidence of papillary thyroid cancer (PTC) has been rapidly increasing in recent years. PTC is prone to lymph node metastasization, which further increases the recurrence rate and mortality cancer. However, underlying mechanisms this process remain elusive. Several reports have shown that microRNA miR-215 plays an important role metastasis. Here, we investigated, for first time, potential association between metastasis PTC. results qPCR analysis demonstrated was downregulated cell lines...
BACKGROUND:We investigated the role of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated (ERK) signaling pathway in finasteride-induced hypospadias rats and explored mechanisms involved. MATERIAL AND METHODS:The model was established by intragastric administration finasteride confirmed hematoxylin eosin (HE) staining. The urethral plate fibroblasts (UPF) were obtained from normal modeled identified based upon vimentin expression. Thereafter, UPF divided into a control...
Terminal differentiation-induced ncRNA (TINCR) plays an essential role in epidermal differentiation and is involved the development of various cancers.qPCR was used to detect expression level TINCR tissues cell lines laryngeal squamous carcinoma (LSCC). The potential targets were predicted by bioinformation website. miR-210 BTG2 genes detected qPCR, protein levels Ki-67 evaluated western blot. CCK-8 assay, scratch test, transwell chamber evaluate proliferation, invasion, metastasis ability...
Papillary thyroid cancer (PTC) is the most common form of and characterized by its tendency for lymphatic metastasis, leading to a poor prognosis. Tetraspanin 1 (TSPAN1) member tetra-transmembrane protein superfamily has been implicated in tumorigenesis metastasis various studies. However, role TSPAN1 PTC tumor development remains unclear. In this study, we aimed investigate impact on cell behavior. Our results demonstrate that knockdown inhibits proliferation, migration, invasion, while...
TRAF6 is an E3 ubiquitin ligase that transduces signals from members of the TLR/IL‐1R family. Multiple molecules have been found to associate with and exert their functions in this pathway. Herein, by yeast two‐hybrid screen using as bait, we identified PP4 a potential TRAF6‐interacting protein. physically interacted was recruited TLR4 complex upon LPS stimulation. negatively regulated LPS‐induced TRAF6‐mediated NF‐κB activation inhibiting ubiquitination TRAF6. stimulation also induced...
Abstract Pygopus, a very important component of the Wnt signaling transcriptional complex, has multiple functions in both Wnt-dependent and -independent pathways. Human Pygopus2 (Pygo2) is expressed many cancers plays an role tumor growth. In present study, we generated human carcinoma (HeLa) cell lines stably expressing Pygo2, which counteracts vinblastine-induced apoptosis. The anti-apoptotic function was determined by DNA fragmentation, sub-G1 appearance, loss mitochondrial membrane...
Objective To investigate the effect of downregulation Galectin-3 gene expression on proliferation and apoptosis neuroblastoma. Methods The mRNA protein in neuroblastoma tissues were detected by reverse transcriptase-polymerase chain reaction (RT-PCR) Western blotting; Galectin-3-siRNA (small interfering RNA) was transfected into human cell line SK-N-SH, a negative control group (NC-siRNA) (Control) set, Galectin-3, Cleaved Caspase-3, phosphatidylinositol 3 kinase (PI3K),...