A5013666232- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Immunotherapy and Immune Responses
- HIV Research and Treatment
- CAR-T cell therapy research
- Alzheimer's disease research and treatments
- NF-κB Signaling Pathways
- HIV/AIDS Research and Interventions
- Chemokine receptors and signaling
- Mitochondrial Function and Pathology
- HIV/AIDS drug development and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
WinnMed
2024-2025
Mayo Clinic
2022-2024
Mayo Clinic in Arizona
2024
Mayo Clinic in Florida
2021-2023
Abstract Durable T cell immunity against cancer depends on the continual replenishment of effector CD8+ cells. Thymic output has been correlated with favorable prognosis in patients across a range ages, suggesting that thymus is an important source for replenishing cells capable controlling progression. However, potential thymic mature and their regulation have not clearly defined. In this study, we identified ability single positive to gain after selection, but they are subject PD-1. We...
Achieving a functional or sterilizing cure for HIV will require identification of therapeutic interventions that reduce reservoir size in infected individuals. Proteasome inhibitors, such as ixazomib, impact multiple aspects biology including latency, transcription initiation, viral replication, and cell killing through the protease - Casp8p41 pathway, resulting latency reversal reduced measures ex vivo.
Abstract Microglia activation is a hallmark feature of the immune response associated with neurological disease. In neuropathological conditions, microglia become fully competent antigen presenting cells and are proposed to perpetuate T cell in brain. Historically, it has been difficult define extent enhance CD8 responses brain through MHC class I restricted presentation. Using novel single Class Cre Lox approach developed by our laboratory which H-2Kb can be deactivated Tmem119+ cells, we...
Abstract Alzheimer's disease (AD) is among the most common neurodegenerative diseases in which a role for immune cells its etiology only beginning to be realized. AD has two molecular pathological hallmarks: presence of amyloid beta (Aβ) plaques and tau tangles within neuronal cells. The can modeled mice by inserting transgenes that enhance human Aβ create inside mouse brain. Amyloid precursor protein (Mo/HuAPP695swe) mutant presenilin 1 (PS1-dE9) are inserted into C57BL/6 results...
Abstract α-PD-1 checkpoint blockade is a promising immunotherapeutic approach for many solid tumors; however, this strategy minimally effective GBM patients as monotherapy. One potential reason why ineffective the tumor microenvironment and systemic derangements of immune system which are prevalent in patients. We have successfully modeled peripheral experimental murine models. These include low blood CD4 T cell counts, reduced MHC class II expression on monocytes, atrophy primary organs...