A5001796557- Fern and Epiphyte Biology
- Biological Activity of Diterpenoids and Biflavonoids
- Natural product bioactivities and synthesis
- Endometriosis Research and Treatment
- Plant Gene Expression Analysis
- Bioactive natural compounds
- Plant and animal studies
- Botanical Research and Applications
- Reproductive System and Pregnancy
- Microencapsulation and Drying Processes
- Cassava research and cyanide
- Polysaccharides and Plant Cell Walls
- Phytochemicals and Antioxidant Activities
- Immunodeficiency and Autoimmune Disorders
- Autoimmune and Inflammatory Disorders Research
- Plant Diversity and Evolution
- Biocrusts and Microbial Ecology
- Plant biochemistry and biosynthesis
- Polysaccharides Composition and Applications
- Aquaculture disease management and microbiota
- Zebrafish Biomedical Research Applications
- Essential Oils and Antimicrobial Activity
- Biochemical Analysis and Sensing Techniques
- Urticaria and Related Conditions
- Cervical Cancer and HPV Research
Universidade Federal do Rio Grande do Norte
2014-2024
Leiden University
2022-2024
CONTEXT AND OBJECTIVE:Impaired local cell immunity seems to contribute towards the pathogenesis and progression of cervical intraepithelial neoplasia (CIN), but underlying molecular mechanisms promoting its remain unclear. Identification new markers for prognosis diagnosis early-stage CIN may aid in decreasing numbers cases. Several novel immunoregulatory molecules have been discovered over past few years, including human leukocyte antigen G (HLA-G), which through interaction with receptors...
Erythrina velutina is a Brazilian native tree of the Caatinga (a unique semiarid biome). It widely used in traditional medicine showing anti-inflammatory and central nervous system modulating activities. The species rich source specialized metabolites, mostly alkaloids flavonoids. To date, genomic information, biosynthesis, regulation flavonoids remain unknown this woody plant. As part larger ongoing research goal to better understand metabolism plants inhabiting harsh conditions Caatinga,...
Sisal is a common stiff fibre produced around the world, corresponding to approximately 70% of commercial production all fibres this type. The are extracted from leaves Agave sisalana, which 4% their weight obtained, with remaining 96% considered be residues process sisal industry. objective work was obtain polyphenol-enriched extract A. sisalana residue by ultrasonically assisted extraction, characterize it chemically, evaluate in vitro antioxidant activity, and develop safe stable...
Abstract Selaginella convoluta is a desiccation tolerant plant native to the Brazilian semiarid region (Caatinga), endowed with an effective drought resistance mechanism. As part of our research efforts understand chemical diversity S. convoluta, dehydrated (harvested in their natural habitat dry season) and hydrated (plant acclimated laboratory after rehydration) specimens were analyzed by HR-LC-ESI-MS/MS followed structural annotation on Global Natural Products Social Molecular Networking...
Natural products of pharmaceutical interest often do not reach the drug market due to associated low yields and difficult extraction. Knowledge biosynthetic pathways is a key element in development biotechnological strategies for plant specialized metabolite production. Erythrina species are mainly used as central nervous system depressants folk medicine important sources bioactive tetracyclic benzylisoquinoline alkaloids (BIAs), which can act on several pathology-related biological targets....
H. pylori is a potent pathogen due to its capacity successfully evade host defence mechanisms. Despite inducing immune responses in infected individuals, sometimes these fail clear the infection and bacterium establishes persistent leading chronic inflammation. In this context, we hypothesized that human leucocyte antigen G (HLA-G), non-classical major histocompatibility complex molecule has ability regulate both physiological pathological conditions, may play an important role promoting...
Abstract Tropane alkaloids are specialized plant metabolites mostly found in the Erythroxylaceae and Solanaceae families. Although tropane have a high degree of structural similarity because ring, their pharmacological actions quite distinct. Brazil is one main hotspots Erythroxylum spp. diversity with 123 species (almost 66% catalogued tropical America). pungens occurs Caatinga, promising biome that provides bioactive compounds, including alkaloids. As part our efforts to investigate this...
Kaposi’s sarcoma (KS) is a low-grade vascular tumor that presents most frequently with skin lesions. Multiple factors are related to KS pathogenesis. The interleukin-23 (IL-23) an immunomodulatory cytokine pro-carcinogenic role. aim of this study was evaluate the detection IL-23 in cutaneous lesions patients classic and KS-AIDS. This cross-sectional conducted at public Hospital Natal, Rio Grande do Norte, Brazil. included 13 biopsies which presented histopathological confirmation. For IL-23,...
Selaginella convoluta is a desiccation-tolerant lycophyte capable of enduring water deprivation by arresting its metabolism when dry and reactivating it upon rehydration. Mechanisms to mitigate the harmful effects desiccation have been investigated in an evolutionary context; however, plants additional species-specific strategies refined environmental conditions. Previous metabolome analysis pointed out S. as source chemodiversity. Shotgun proteomic analysis, conducted using Orbitrap Elite...
Selaginella is the only genus from Selaginellaceae, and it considered a key factor in studying evolution. The family managed to survive many biotic abiotic pressures during last 400 million years. purpose of this review provide an up-to-date overview order recognize their potential evaluate future research opportunities. Carbohydrates, pigments, steroids, phenolic derivatives, mainly flavonoids, alkaloids are main natural products Selaginella. A wide spectrum vitro vivo pharmacological...
Herein the descriptive label-free mass spectrometry (LC-MS/MS) proteome of Erythroxylum pungens (roots, barks, leaves) harvested from its natural habitat is described. Processes related to defense were most important in roots. Main protective proteins differed among organs, suggesting part-specific strategies environmental adaptation.