A5048393560- Animal Behavior and Welfare Studies
- Cell Adhesion Molecules Research
- Meat and Animal Product Quality
- Human-Animal Interaction Studies
- Acute Myeloid Leukemia Research
- Sociology and Education Studies
- HER2/EGFR in Cancer Research
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Psychology, Coaching, and Therapy
- Heart Rate Variability and Autonomic Control
- Criminal Law and Policy
- Galectins and Cancer Biology
- Epigenetics and DNA Methylation
- Animal Nutrition and Physiology
- Rheumatoid Arthritis Research and Therapies
- Olfactory and Sensory Function Studies
- Medicinal Plant Pharmacodynamics Research
- Spondyloarthritis Studies and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Ubiquitin and proteasome pathways
- Osteoarthritis Treatment and Mechanisms
- Biochemical Analysis and Sensing Techniques
- Primate Behavior and Ecology
- Cellular Mechanics and Interactions
- Endoplasmic Reticulum Stress and Disease
Research Institute for Farm Animal Biology (FBN)
2015-2025
University Hospital Münster
2017-2024
Schweißtechnische Lehr- und Versuchsanstalt
2022
University of Roehampton
2022
Trinity University
2022
Konrad Lorenz Institute for Evolution and Cognition Research
2022
University of Vienna
2022
Wockhardt (United States)
2022
Sozialwissenschaftliche Forschung und Beratung
2022
Carl von Ossietzky Universität Oldenburg
2020
Play behaviour has been suggested to be inherently rewarding for animals, inducing positive emotional states. The psychophysiological effect of emotions can assessed through heart rate variability (HRV), serving as a proxy measure sympathovagal balance. This study investigated how the performance play influences (HR) and HRV parameters (RMSSD, SDNN) in pigs. It was hypothesized that would increase during immediately after due predominant vagal activation compared baseline, indicating state....
Rheumatoid arthritis synovial fibroblasts (RASFs) are known to travel via the bloodstream from sites of cartilage destruction new locations where they reinitiate destructive processes at distant articular surfaces. In this study, we examined role interleukin (IL)-1-induced changes and their chemotactic effect on RASF transmigratory capacity. To investigate fibroblast (SF) transmigration through endothelial layers, used a modified Boyden chamber with an endothelioma cell layer (bEnd.5) as...
Abstract The LIM and SH3 domain protein 1 (Lasp1) was originally cloned from metastatic breast cancer characterised as an adaptor molecule associated with tumourigenesis cell invasion. However, the regulation of Lasp1 its function in aggressive transformation cells is unclear. Here we use integrative epigenomic profiling invasive fibroblast-like synoviocytes (FLS) patients rheumatoid arthritis (RA) mouse models disease, to identify epigenomically co-modified region chronic inflammatory a...
In the field of rheumatology, conventional diagnostic methods permit detection only advanced stages disease, which is at odds with current clinical demand for early diagnosis inflammatory rheumatic diseases. Prompted by needs, we developed a finger joint phantom that enables optical and geometrical simulation an stage rheumatoid arthritis (RA). The results presented here form experimental basis evaluation new RA systems based on near infrared light. characterised mainly vigorous...
Based on individual adaptive strategies (coping), animals may react differently to environmental challenges in terms of behavior and physiology according their emotional perception. Emotional valence as well arousal be derived by measuring vagal sympathetic tone the autonomic nervous system (ANS). We investigated situation-dependent response 16 domestic pigs with either a reactive or proactive coping style, previously selected backtest which is accepted piglets assess escape behavior. At 11...
Abstract The aim of the study was to investigate influence intraperitoneal N -arachidonoylethanolamide (AEA) on taste preference for feed and water, tongue receptor signalling ( TAS1R2 , GNAT3 ), endocannabinoid CNR1 CNR2 GPR55 ) opioid OPRD1 OPRK1 OPRM1 OPRL1 receptors in amygdala nucleus accumbens periparturient cows. We conducted tests using unaltered, umami-tasting, sweet-tasting water feed, before after calving. After calving, eight cows received AEA injections (3 µg/(kg bodyweight ×...
In addition to domestication, interactions with humans or task-specific training during ontogeny have been proposed play a key role in explaining differences human-animal communication across species. livestock, even short-term positive caretakers other reference persons can influence interaction at different levels and over periods of time. this study, we investigated human-directed behaviour the 'unsolvable task' paradigm two groups domestic goats (Capra aegagrus hircus). One group was...
Abstract Altering one’s emotional state in response to the expressions of others, called contagion, is a well-studied phenomenon humans and many nonhuman animals. Here we describe methods that are typically used assess changes demonstrators transmission emotions naïve observers. We then review evidence for positive negative farm conclude by highlighting examples how better understanding contagion animals can lead novel innovative interventions improve their welfare.
External signals that are mediated by specific receptors determine stem cell fate. The thrombin receptor PAR1 plays an important role in haemostasis, thrombosis and vascular biology, but also tumor biology angiogenesis. Its expression function hematopoietic cells is largely unknown. Here, we analyzed of primary their leukemic counterparts. AML patients' blast expressed much lower levels mRNA protein than CD34+ progenitor cells. Constitutive Par1-deficiency adult mice did not affect...
A wide range of species exhibit time- and context-consistent interindividual variation in a number specific behaviors related to an individual's personality. Several studies have shown that individual differences personality-associated behavioral traits impact on cognitive abilities. The aim this study was investigate the relationship between personality learning abilities dwarf goats. behavior 95 goats during repeated open field (OF) novel object test (NO) analyzed, two main components were...
Abstract Both humans and nonhuman animals need to show self-control wait for a larger or better reward instead of smaller less preferred but instant on an everyday basis. We investigated whether this ability undergoes ontogenetic development in domestic pigs (similar what is known human infants) by testing if how long nine- 16-week-old amount their reward. In delay-of-gratification task, first learned that small was hidden under white cup large black cup, then the delay deliver gradually...
Introduction: Sheep are frequently used in translational surgical orthopedic studies. Naturally, a good pain management is mandatory for animal welfare, although it also important with regard to data quality. However, methods adequate severity assessment, especially considering pain, rather rare regarding large models. Therefore, the present study, accompanying pilot telemetry and Grimace Scale (SGS) were addition clinical scoring assessment after interventions sheep. Methods: Telemetric...
<h3>Objective</h3> To analyze the IL-6 signaling pathway in SLE to better understand why CRP levels are disproportionally low for increased active SLE, but increase bacterial infection same patients. <h3>Methods</h3> PBMC and sera of 41 patients 71 healthy individuals (HC) were investigated. soluble receptor (sIL-6R) measured by ELISA. CD126 phosphorylated Stat3 (pStat3) stained with phycoerythrin (PE)-labelled antibodies. incubated short term or 24 hours without IL-6, IL-10, TNF,...
This study assessed the interchangeability between heart rate (HR) and variability (HRV) measures derived from a series of interbeat intervals (IBIs) recorded via electrocardiogram (ECG) intra-arterial blood pressure (BP) in various behavioral contexts. Five minutes simultaneously IBIs ECG BP signals 11 female domestic pigs during resting, feeding active behavior were analyzed. Comparisons made for HR, SDNN (the standard deviation IBIs) RMSSD root mean squared distances subsequent each...
Eine Vielzahl der inhaftierten Jugendlichen wurde durch ihr (soziales) Umfeld delinquent sozialisiert und hat abweichende (maladaptive) Verhaltensweisen internalisiert, um im Alltag zuRECHT zu kommen. Das Recht jungen delinquenten Menschen wird bestimmt von internalisierten Regeln Gesetzen ihrer Lebenswelt. Daran anknüpfend benötigen wir Konzepte nicht-delinquenter Coping-Strategien.
<h3>Background</h3> In rheumatoid arthritis (RA) the attachment of synovial fibroblasts to articular cartilage is an important prerequisite in process degradation. The actin-associated protein Lasp-1 involved processes actin organisation and polymerization focal adhesion turnover, respectively. Therefore, we investigated its role regulating cell-cell contacts ECM interactions RA. <h3>Methods</h3> expression was analysed human RA tissue arthritic mouse models such as hTNFtg G6PI model by...
<h3>Career situation of first and presenting author</h3> Post-doctoral fellow. <h3>Introduction</h3> In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) undergo a stable transformation resulting in an aggressive, tumour-like phenotype that mediates cartilage damage by increased levels MMPs adhesion molecules such as β1 integrins. this context, the tumour-associated protein Lasp1 is interest because it modulates actin organization focal turnover. <h3>Objectives</h3> The effects...