A5079613165- Sleep and Wakefulness Research
- Sleep and related disorders
- Health Systems, Economic Evaluations, Quality of Life
- Hormonal and reproductive studies
- Dementia and Cognitive Impairment Research
- Patient Satisfaction in Healthcare
- Telemedicine and Telehealth Implementation
- Youth Substance Use and School Attendance
- Children's Physical and Motor Development
- Muscle metabolism and nutrition
- Health disparities and outcomes
- Sports Performance and Training
- Parkinson's Disease and Spinal Disorders
- Alzheimer's disease research and treatments
- Menopause: Health Impacts and Treatments
- Healthcare Systems and Technology
- Doping in Sports
- Neurological disorders and treatments
- Sleep and Work-Related Fatigue
- Parkinson's Disease Mechanisms and Treatments
- Health, Environment, Cognitive Aging
- Statistical Methods in Clinical Trials
- Advanced Causal Inference Techniques
- Nutritional Studies and Diet
- Nuclear Receptors and Signaling
Boston University
2010-2021
VA New England Healthcare System
2021
Edith Nourse Rogers Memorial Veterans Hospital
2020
Boston Medical Center
2010-2013
Testosterone supplementation has been shown to increase muscle mass and strength in healthy older men. The safety efficacy of testosterone treatment men who have limitations mobility not studied.
Testosterone in Older Men with Mobility Limitations Trial determined the effects of testosterone on muscle performance and physical function older men mobility limitation. Trial's Data Safety Monitoring Board recommended enrollment cessation due to increased frequency adverse events arm. The changes were evaluated relation participant's perception change. aged 65 years older, limitation, total 100–350 ng/dL, or free less than 50 pg/mL, randomized placebo 10 g gel daily for 6 months. Primary...
This study aims to determine the dose-dependent effects of testosterone on sexual function, body composition, muscle performance, and physical function in hysterectomized women with or without oophorectomy.Seventy-one postmenopausal who previously underwent hysterectomy oophorectomy had total levels less than 31 ng/dL free 3.5 pg/mL received a standardized transdermal estradiol regimen during 12-week run-in period were randomized receive weekly intramuscular injections placebo 3, 6.25, 12.5,...
Objective: Telehealth offers the opportunity to address a growing need improve access specialty services, such as neuropsychology, particularly for older adults and those in rural areas. Initial research has examined validity acceptability of teleneuropsychology (teleNP) settings, but there is less information about teleNP implementation clinical practice. Here we describe development clinic compare patient satisfaction completing in-person neuropsychological evaluations. Method: A was...
Objectives: This pilot project aimed to explore a new model of healthcare delivery older adult medically complex Veterans by combining telehealth technology with an interdisciplinary medical team operating in real time.Methods: The Geriatric-Interdisciplinary Mobile Patient Access Team (G-IMPACT) was comprised field including nurse practitioner and assistant who visited enrolled patients their homes using synchronous video link suite geriatric specialists video-enabled room at Affairs...
Parkinson's disease (PD) presents with extensive heterogeneity in symptomatology, inviting examination of subtypes. One significant categorization is by whether patients present at onset tremor as the dominant symptom (TD) or nontremor symptoms (NTD). We examined differences quality life between TD and NTD using Disease Questionnaire-39 (PDQ-39), correlating performance aspects motor function indexed Unified Rating Scale (UPDRS). Participants included 35 nondemented individuals (19 TD, 16...
While the influence of sleep on motor memory consolidation has been extensively investigated, its relation to initial skill acquisition is less well understood. The purpose present study was investigate quality and quantity subsequent in young adults without disorders. Fifty-five healthy (mean age = 23.8 years; 34 women) wore actigraph wristbands for 4 nights, which provided data patterns before experiment, then returned laboratory engage a sequence learning task (explicit 5-item finger...
Abstract Background In Alzheimer’s Disease trials, the Mini‐Mental State Examination (MMSE) and Clinical Dementia Rating (CDR) are commonly utilized as inclusionary criteria at screening. These measures, however, do not always reaffirm status baseline. Score changes between screening baseline visits may imply potential score inflation leading to inappropriate participant enrollment. This study compared in global AD trials when MMSE CDR scores were used measures only versus visits. We...
Abstract Background The Mini‐Mental State Examination (MMSE) is a common screening tool in Alzheimer’s disease (AD) clinical trials. MMSE score inflation at inclusionary visits poses challenges by potentially amplifying placebo responses and complicating the detection of treatment effects. Despite these concerns, prior research (e.g., Echevarria, 2023) has reported instances when it utilized as an inclusion criterion. Little known, however, whether this phenomenon observed universally AD...
Abstract Background Alzheimer’s disease (AD) clinical trials are increasingly global. Most measures used were validated and standardized with North American, White, English‐speaking populations limited consideration of cultural nuance. Prior research suggests that both the Clinical Dementia Rating (CDR) Mini Mental State Examination (MMSE) not free from linguistic influence. It is important to understand how geo‐cultural factors influence longitudinal change in scores on these measures,...
Aim: Smartphone technology is increasingly used by the public to assess sleep. Specific features of some sleep-tracking applications are comparable actigraphy in objectively monitoring The clinical utility smartphone apps should be investigated further increase access convenient means Methods: and subjective sleep measures were administered 29 community-dwelling healthy adults [aged 20-67, Mean (M) = 26.8; 18 women, 11 men], 19 them. Total time (TST) efficiency measured with Sleep Time app...
Abstract Background In addition to measures of cognition, global Alzheimer’s disease (AD) clinical trials commonly include assess functional status (activities daily living; ADLs) and quality life (QoL) reported by participants study partners. Most common assessments were validated with North American, White, English‐speaking populations research suggests that these are not free from cultural linguistic influence. ADLs QoL may exhibit regional differences due socioeconomic factors. It is...
Abstract Background The increasingly global scope of clinical trials in Alzheimer’s disease (AD) has led to the recruitment subjects from various geo‐cultural regions. Recent studies suggest that commonly used objective measures cognition such as MMSE well subjective, clinician‐rated CDR might be impacted by cultural and/or linguistic differences. This raises question regarding impact differences on convergent validity and MMSE. In this analysis, we examined extent which correspondence...