A5042325892- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Cancer Cells and Metastasis
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Mitochondrial Function and Pathology
- Silicone and Siloxane Chemistry
- Electrohydrodynamics and Fluid Dynamics
- Autophagy in Disease and Therapy
- Microbial Metabolic Engineering and Bioproduction
- Neuroscience and Neural Engineering
- Space Exploration and Technology
- Tissue Engineering and Regenerative Medicine
- Fluid Dynamics and Thin Films
- Silk-based biomaterials and applications
- Titanium Alloys Microstructure and Properties
- Advanced Materials and Mechanics
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanoparticle-Based Drug Delivery
- Orthopaedic implants and arthroplasty
- Conferences and Exhibitions Management
University of Glasgow
2014-2023
University of Manchester
2012-2014
Institute of Molecular Medicine
2014
Out of their niche environment, adult stem cells, such as mesenchymal cells (MSCs), spontaneously differentiate. This makes both studying these important regenerative and growing large numbers for clinical use challenging. Traditional cell culture techniques have fallen short meeting this challenge, but materials science offers hope. In study, we used emerging rules managing adhesion/cytoskeletal balance to prolong MSC cultures by fabricating controllable nanoscale interfaces using...
Abstract Mesenchymal stromal cells (MSCs) are multipotent progenitor that of considerable clinical potential in transplantation and anti-inflammatory therapies due to their capacity for tissue repair immunomodulation. However, MSCs rapidly differentiate once culture, making large-scale expansion use immunomodulatory challenging. Although the differentiation mechanisms have been extensively investigated using materials, little is known about how materials can influence paracrine activities...
In culture isolated bone marrow mesenchymal stem cells (more precisely termed skeletal cells, SSCs) spontaneously differentiate into fibroblasts, preventing the growth of large numbers multipotent SSCs for use in regenerative medicine. However, mechanisms that regulate expansion SSCs, while maintaining multipotency and fibroblastic differentiation are poorly understood. Major hurdles to understanding how maintenance is regulated (a) from heterogeneous populations with different proliferative...
Nanotopographical cues observed<italic>in vivo</italic>(such as in the sinusoid and bone) closely resemble nanotopographies that<italic>in vitro</italic>have been shown to promote niche relevant stem cells behaviours; specifically, retention of multipotency osteogenic differentiation on ordered disordered nano-pits respectively. These other observations highlight a potential role for nano topography cell niche.
Accelerated de novo formation of bone is a highly desirable aim implants targeting musculoskeletal injuries. To date, this has primarily been addressed by biologic factors. However, there an unmet need for robust, reproducible yet economic alternative strategies that strongly induce osteogenic cell response. Here, we present surface engineering method translating bioactive nanopatterns from polymeric in vitro studies to clinically relevant material orthopedics: three-dimensional, large area...
Mesenchymal stem cells (MSCs) are multipotent that immunosuppressive and thus of considerable therapeutic potential in transplant operations. However, MSCs rapidly differentiate once culture, making their large-scale expansion for use therapies challenging. Although the differentiation mechanisms have been extensively investigated using materials, little is known about how materials can modulate paracrine activities MSCs. Here, we show first time nanotopography control immunomodulatory...
The presentation illustrates the results of an interdisciplinary practice between main author as art jeweller and engineering with material science. talk will be supported by a series examples surface marking titanium laser for production jewellery objects effects caused heat delivered to substrate. research demonstrates how controlled oxide growth on can used artistic tool producing precisely defined colours according different parameter setting. overriding success this work, however, is...