Graphene oxide (GO) is one of the most studied nanomaterials in many fields, including biomedical field. Most developed for drug delivery and phototherapies are based on noncovalent approaches that lead to an unspecific release physisorbed molecules complex biological environments. Therefore, preparing covalently functionalized GO using straightforward versatile methods highly valuable. Phototherapies, photothermal therapy (PTT) photodynamic (PDT), have shown great potential as effective...

H(2)FcPh(3)P [FcPh(3)P = 5-ferrocenyl-10,15,20-triphenyl porphyrin(2-)], cis-H(2)Fc(2)Ph(2)P [cis-Fc(2)Ph(2)P 5,10-bisferrocenyl-15,20-diphenyl trans-H(2)Fc(2)Ph(2)P [trans-Fc(2)Ph(2)P 5,15-bisferrocenyl-10,20-diphenyl and H(2)Fc(3)PhP [Fc(3)PhP 5,10,15-trisferrocenyl-20-phenyl porphyrin(2-)] along with H(2)TPP [TPP 5,10,15,20-tetraphenylporphyrin] H(2)TFcP [TFcP 5,10,15,20-tetraferrocenyl were isolated from the direct cross-condensation reaction between pyrrole, benzaldehyde, ferrocene...

Abstract Carbon‐based nanomaterials have demonstrated to be potent candidates for biomedical applications. Recently, graphene quantum dots (GQDs) emerged as an attractive tool bioimaging, biosensing, and therapy. Hence, studying their biodegradability in living systems is essential speed up the translation toward real clinical innovations. Here, enzymatic degradation of GQDs using human myeloperoxidase eosinophil peroxidase investigated. Transmission electron microscopy, fluorescence, Raman...

The design of multifunctional materials able to both selectively deliver a drug into cells in targeted manner and display an enhanced propensity for biodegradation is important goal. Here, graphene oxide (GO) functionalized with the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (fMLP) known interact formyl receptor, which expressed different cancer cells, including cervical carcinoma cells. This study highlights ability GOfMLP delivery cell killing subsequent degradation...

The graphene revolution, which has taken place during the last 15 years, represented a paradigm shift for science. extraordinary properties possessed by this unique material have paved road to number of applications in materials science, optoelectronics, energy, and sensing. Graphene-related (GRMs) are now produced large scale found niche also biomedical technologies, defining new standards drug delivery biosensing. Such advances position GRMs as novel tools fight against current COVID-19...

Synapses compute and transmit information to connect neural circuits are at the basis of brain operations. Alterations in their function contribute a vast range neuropsychiatric neurodegenerative disorders synapse-based therapeutic intervention, such as selective inhibition synaptic transmission, may significantly help against serious pathologies. Graphene is two-dimensional nanomaterial largely exploited multiple domains science technology, including biomedical applications. In hippocampal...

Controlled intracellular release of exogenous reactive oxygen species (ROS) is an innovative and efficient strategy for cancer treatment. Well-designed materials, which can produce ROS in targeted cells, minimizing side effects, still need to be explored as new generation nanomedicines. Here, red-emissive carbon nanodots (CNDs) with intrinsic theranostic properties are devised, further modified folic acid (FA) ligand through a controlled covalent functionalization cell imaging production...

Graphene and other 2D materials, such as molybdenum disulfide, have been increasingly used in electronics, composites, biomedicine. In particular, MoS2 graphene hybrids attracted a great interest for applications the biomedical research, therefore stimulating pertinent investigation on their safety immune cells like macrophages, which commonly engulf these materials. this study, M1 M2 macrophage viability activation are mainly found to be unaffected by few-layer (FLG) at doses up 50 µg mL-1...

Boron neutron capture therapy (BNCT) is a non-invasive cancer treatment with little adverse effect utilizing nuclear fission of 10 B upon irradiation. While source has been developed from reactor to compact accelerator, only two kinds drugs, boronophenylalanine and sodium borocaptate, have clinically used for decades despite their low tumor specificity and/or retentivity. To overcome these challenges, various boron-containing nanomaterials, or "nanosensitizers", designed based on micelles,...

Abstract In this work, the mechanisms of radical generation on different functionalized graphene oxide (GO) conjugates under near‐infrared (NIR) light irradiation are investigated. The GO designed to understand how chemical functionalization can influence radicals. Both pristine and irradiated by a NIR laser, production reactive oxygen species (ROS) is investigated using fluorimetry electron paramagnetic resonance describe type radicals present surface GO. mechanism ROS formation involves...

Triple-negative breast cancer (TNBC) is an aggressive form of defined by the lack three key receptors: estrogen, progesterone, and HER2. This receptors makes TNBC difficult to treat with hormone therapy or drugs, so it characterised a poor prognosis compared other kinds cancer. study explores photoactive Poly(lactic-co-glycolic acid) (PLGA) nanoparticles as potential therapeutic strategy for TNBC. The are functionalised hyaluronic acid (HA) targeted delivery CD-44 overexpressed in cells,...

ABSTRACT The increasing emergence of antimicrobial resistance and the development new infective viral strains represent a constantly growing threat. Metal‐based nanomaterials have emerged as promising tools in fight against bacterial infections; however, release metal nanoparticles/ions clinical applications may cause undesired side effects (allergies, systemic toxicity), reducing their practical use treatment. Moreover, metal‐based nanoparticles possess predominantly antibacterial effects,...

Graphene oxide complexed with calcium phosphate nanoparticles enhances bone regeneration through signalling between monocytes and mesenchymal stem cells.

Gene therapy has attracted tremendous attention as a promising method for the treatment of many diseases. Graphene oxide (GO), oxidized form graphene, is showing lot potential in this field. Indeed, polar GO oxygenated functional groups make material highly hydrophilic, leading to good dispersibility water. Until now, interaction small interference RNA (siRNA) with graphene materials not been elucidated. The main goal work was develop novel platform complex siRNA molecules and rationalize...

The last decade has seen an increase in the application of graphene oxide (GO) biomedical field. GO been successfully exploited for its ability to deliver many kinds drugs into target cells. However, toxicity assessment is still controversial. Several studies have demonstrated that protein coating crucial alleviate material's toxicity. Besides, coronation leads formation big agglomerates, reducing cellular uptake material and thus therapeutic efficiency. In this work, we propose a simple...

Abstract: For the first time, we coupled reduced detonation nanodiamonds (NDs) with a plant secondary metabolite, citropten (5,7-dimethoxycoumarin), and demonstrated how this complex was able to reduce B16F10 tumor cell growth more effectively than treatment pure molecule. These results encouraged us find out specific mechanism underlying phenomenon. Internalization kinetics quantification of in cells after its or ND-conjugated form were measured, it revealed that coupling between NDs...

We systematically studied the interactions between graphene oxide (GO) and siRNA. The siRNA secondary structure is damaged by interaction with GO sheets. Functionalization of polyethyleneimine able to protect from structural modifications.

The synthesis of a drug delivery platform based on graphene was achieved through step-by-step strategy selective amine deprotection and functionalization. multifunctional platform, functionalized with indocyanine green, folic acid, doxorubicin showed an enhanced anticancer activity. remarkable targeting capacity for cancer cells in combination the synergistic effect release photothermal properties prove great advantage combined chemo- phototherapy against cancer, opening doors to future...

Conductive coatings made of template-free polymerized PEDOT/ND nanoparticles with peculiar enhancement mechanical properties and endurance to electron damage.

In this paper we present some strategies that are being developed in our labs towards enabling nanodiamond-based applications for drug delivery. Rhodamine B (RhB) has been choosen as model molecule to study the loading of nanodiamonds with active moieties and conditions their controlled release. order test chemical/physical interactions between functionalized detonation nanodiamond (DND) complex molecules, prepared tested different RhB@DND systems, RhB adsorbed or linked by ionic bonding DND...