A5044084209- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Mycobacterium research and diagnosis
- SARS-CoV-2 and COVID-19 Research
- Cystic Fibrosis Research Advances
- SARS-CoV-2 detection and testing
- Medical Research and Treatments
- Intensive Care Unit Cognitive Disorders
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Psychosomatic Disorders and Their Treatments
- Respiratory Support and Mechanisms
- Biliary and Gastrointestinal Fistulas
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Intestinal Malrotation and Obstruction Disorders
- COVID-19 and healthcare impacts
- Infective Endocarditis Diagnosis and Management
- COVID-19 diagnosis using AI
- Infectious Diseases and Mycology
- Gastrointestinal disorders and treatments
- Pleural and Pulmonary Diseases
- Pneumothorax, Barotrauma, Emphysema
Ghent University Hospital
2011-2024
Ghent University
2021
Long-term outcome data of coronavirus disease 2019 (COVID-19) survivors are needed to understand their recovery trajectory and additional care needs.A prospective observational multicentre cohort study was carried out adults hospitalised with COVID-19 from March through May 2020. Workup at 3 12 months following admission consisted clinical review, pulmonary function testing, 6-min walk distance (6MWD), muscle strength, chest computed tomography (CT) quality life questionnaires. We evaluated...
GM-CSF promotes myelopoiesis and inflammation, blockade is being evaluated as a treatment for COVID-19-associated hyperinflammation. Alveolar is, however, required monocytes to differentiate into alveolar macrophages (AMs) that control homeostasis. By mapping cross-species AM development clinical lung samples, we discovered COVID-19 marked by defective GM-CSF-dependent instruction accumulation of pro-inflammatory macrophages. In multi-center, open-label RCT in 81 non-ventilated patients with...
Patients with chronic lung disease suffer from persistent inflammation and are typically colonized by pro-inflammatory pathogenic bacteria. Besides these pathogens, a wide variety of commensal species is present in the lower airways but their role unclear. Here, we show that microbiota contains several able to inhibit activation NF-κB pathway production interleukin 8 (IL-8), triggered lipopolysaccharide (LPS) or H 2 O , physiologically relevant three-dimensional (3D) epithelial cell model....
Abstract Background/objectives Assessing the clinical relevance of non-tuberculous mycobacteria (NTM) isolated from respiratory samples can be challenging. The epidemiology and pathogenicity NTM species vary geographically. We aimed to outline associated radiological patterns in Belgium. Methods performed a retrospective multicentre analysis all patients identified laboratory database with > 1 sample growing January 2010 through December 2017. collected clinical, microbiological data...
Chlamydia psittaci is a gram-negative, obligate intracellular organism. Birds are the main reservoir, but also non-avian domestic animals and humans can be infected. In it mostly causes respiratory infections due to occupational exposure with varying severity. Sensitive specific diagnostic tests needed define psittacosis in as these allow rapid tracing of animal source. However, diagnosis often based on time-consuming culture techniques antibody detection assays many countries, existing...
Abstract Background Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing pandemic that profoundly challenges healthcare systems all over world. Fever, cough and fatigue are most commonly reported clinical symptoms. Case presentation A 58-year-old man presented at emergency department with onset haemoptysis. On fifth day after admission, he developed massive Computed tomography (CT) angiography of chest revealed...
Abstract Background Invasive pulmonary aspergillosis (IPA) is a relatively common infection in patients with acute myeloid leukaemia (AML), and associated high mortality rates. Optimising early detection key to reduce the burden of IPA this population. In retrospective cohort study, we evaluated added value baseline chest CT before start classical induction chemotherapy. Methods Adult receiving first‐line intensive chemotherapy for AML were included if scan was available (±7 days). Data...
We present the results of COVID-19 rule-out protocol at Ghent University Hospital, a step-wise testing approach which included repeat NFS SARS-CoV-2 rRT-PCR, respiratory multiplex RT-PCR, low-dose chest CT and bronchoscopy with BAL to confirm or infection in patients admitted symptoms suggestive COVID-19.Between 19 March 2020 30 April 2020, 455 non-critically ill suspect for were admitted. The initial rRT-PCR yielded 66.9%, second 25.4% 5.9% total diagnoses. In fluid, other pathogens...
Abstract Multisystem Inflammatory Syndrome in Adult (MIS‐A) is a rare COVID‐19 complication, presenting as fever with laboratory evidence of inflammation, severe illness requiring hospitalization and multisystem organ involvement. We report on 25‐year‐old man fever, rash, abdominal pain, diarrhoea vomiting following prior asymptomatic infection. He developed refractory shock type 1 respiratory insufficiency mechanical ventilation. Diagnostic testing revealed significant anemia,...
Background: Gc-globulin is a polymorphic protein with three phenotypes: Gc 1-1, 2-1 and 2-2. Deglycosylation of results in Gc-macrophage activating factor (Gc-MAF). This study investigated the potential MAF as tumour marker influence Gcphenotypes on serum MAF-concentrations.
Background: A 55-year-old man without relevant medical history was admitted to the emergency department with painful abdominal cramps, vomiting, nausea, and absence of flatus. There no altered bowel habit in last months, melena red blood loss per anum. Physical examination normal except for lower tenderness reduced sounds. Laboratory findings were unremarkable.Conventional radiography abdomen made, followed by MultiDetector Computed Tomography (MDCT) scan abdomen.
It is increasingly recognized that interspecies interactions may modulate the pathogenicity of
This study aimed to evaluate an expanded matrix-assisted laser desorption-ionization-time of flight mass spectrometry (MALDI-TOF MS) database for the identification
<b>Background:</b> Treating NTM-PD can be challenging, as it requires long-term intake of a potentially toxic combination multiple antibiotics with often limited antimycobacterial activity. Because evidence, ATS/IDSA published treatment recommendations to guide clinicians in this process 2007. <b>Objective:</b> We aimed evaluate guideline adherence patients Mycobacterium avium complex pulmonary disease (MAC-PD), the most common form NTM-PD. <b>Methods:</b> performed retrospective,...
Abstract Background/objectives: Assessing the clinical relevance of non-tuberculous mycobacteria (NTM) isolated from respiratory samples can be challenging. The epidemiology and pathogenicity NTM species vary geographically. We aimed to outline associated radiological patterns in Belgium. Methods: performed a retrospective multicentre analysis all patients identified laboratory database with > 1 sample growing January 2010 through December 2017. collected clinical, microbiological data...
Abstract Granulocyte-macrophage colony-stimulating factor (GM-CSF) instructs monocytes to differentiate into alveolar macrophages (AM) that preserve lung homeostasis. By comparing AM development in mouse and human, we discovered COVID-19 patients showed marked defects GM-CSF-dependent instruction. The multi-center, open-label, randomized, controlled SARPAC-trial evaluated the efficacy safety of 5 days inhalation rhu-GM-CSF (sargramostim, Leukine®) 81 non-ventilated with hypoxemic respiratory...