A5026988185- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Nutrition and Health in Aging
- Frailty in Older Adults
- Monoclonal and Polyclonal Antibodies Research
- Body Composition Measurement Techniques
- Archaeological and Historical Studies
- Aging, Health, and Disability
- Immunotherapy and Immune Responses
- Nutritional Studies and Diet
- Health disparities and outcomes
- Medieval Architecture and Archaeology
- Health and Lifestyle Studies
- Ancient Mediterranean Archaeology and History
- Parasitic infections in humans and animals
- CAR-T cell therapy research
- Diet and metabolism studies
- Glycosylation and Glycoproteins Research
- Cardiovascular Health and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Transgenic Plants and Applications
- Regulation of Appetite and Obesity
- Congenital Anomalies and Fetal Surgery
- Alkaline Phosphatase Research Studies
- Immune Response and Inflammation
University of Chile
2016-2024
Hospital Clínico de la Universidad de Chile
2024
Universidad de La Frontera
2024
Montefiore Medical Center
2018
National Institute of Diabetes and Digestive and Kidney Diseases
2018
ProQuest (United States)
2018
Unité de Nutrition Humaine
2017
Virginia Commonwealth University
2008
Instituto Nacional de Neurología y Neurocirugía
2001-2007
Centro de Biología Molecular Severo Ochoa
1986-1998
Abstract INTRODUCTION Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm‐FINGERS) is the first non‐pharmacological multicenter randomized clinical trial (RCT) prevent cognitive impairment in America (LA). Our aim present study design and discuss strategies used multicultural harmonization. METHODS This 1‐year RCT (working on a extension) investigates feasibility of multi‐domain lifestyle intervention LA efficacy intervention, primarily function. An...
In addition to T-lineage cells, a small proportion of hematopoietic non-T cells are present in the human postnatal thymus. However, origin this minor cell thymic compartment is presently unknown. study we have analyzed developmental potential earliest intrathymic precursors, characterized as CD34+ expressing intermediate levels CD44. We show that these CD34+CD44int thymocytes cultured with interleukin 7 were able develop simultaneously into both T- and (monocytes dendritic cells) -lineage...
Sarcopenia is the progressive loss of mass and skeletal muscle strength has serious consequences on older people's health. The Chilean population a high life-expectancy, but prevalence functional dependence also high.To determine sarcopenia in adults its relationship with age, gender, body index (BMI).Cross-sectional study.Community.1,006 non-disabled, community-dwelling subjects aged 60 years or living Santiago.Anthropometric measurements, handgrip strength, physical performance tests,...
This study was aimed to set reference values of hand-grip strength by age and sex validate cut points for risk functional limitation mortality in older Chileans.This a pooled analysis four studies including 6,426 people ≥60 years nondependent community-dwelling Chileans. After exclusion criteria, the final sample included 5,250 subjects, from whom 2,193 were followed all-cause associated with low strength. Face-to-face interviews registering sociodemographic characteristics, self-reported...
Frequency of frailty and its association with cognitive status survival in older Chileans Cecilia Albala,1 Lydia Lera,1 Hugo Sanchez,1 Barbara Angel,1 Carlos Márquez,1 Patricia Arroyo,2 Patricio Fuentes2 1Public Health Nutrition Unit, Institute Food Technology (INTA), University Chile, 2Faculty Medicine, Clinical Hospital, Santiago, Chile Background: Age-associated brain physiologic decline reduced mobility are key elements increased age-associated vulnerability.Objective: To study the...
<sec> <title>BACKGROUND</title> Background: The accelerated aging process in Latin American countries, along with the lack of effective public health strategies to control risk factors, has led an increased prevalence non-communicable diseases (NCD) like cardiovascular and dementia, raising number older adults living a disability. Mobile (mHealth) applications offer promising opportunities encourage healthy lifestyles bridge implementation gap prevention programs. Currently, there are no...
Abstract Introduction Several polymorphisms have been associated with obesity and type 2 diabetes in different populations. Objective To investigate the frequencies of a genetic polymorphism vitamin D receptor (FokI BsmI) patients T2D. Methods The case–control study was conducted 138 T2D 172 control subjects, men women (60–79 years old). genotype allele frequency determination VDR were determined these subjects. Results C FokI significantly higher group than healthy subjects ( p = 0.025)....
In murine T cell development, early thymocytes that productively rearrange the receptor (TCR) beta locus are selected to continue maturation, before TCR alpha expression, by means of a pre-TCR alpha- (pT alpha-) heterodimer (pre-TCR). The aim this study was identify equivalent stages in human thymocyte development. We show here variable-diversity-joining region rearrangement and expression full-length transcripts have been initiated some immature at alpha/beta- CD4+CD8- stage, become common...
Abstract Normal BALB/c mice produce 2,4,6‐trinitrophenyl (TNP)‐I‐A d specific T helper (T h ) cells expressing a receptor heterodimer which share with anti‐TNP antibodies an idiotope defined by the F6(51) anti‐idiotypic antibody. Expression of this idiotype is controlled major histocompatibility complex and immunoglobulin heavy chain‐linked genes results from antibody‐dependent selection cell repertoires (Martinez‐A. et al., Eur. J. Immunol. 1986. 16: 417). We now present evidence for...
Purpose: Many studies have demonstrated that Sarcopenia causes a serious impact on health, including death in older adults. The objective of this study was to determine the association sarcopenia and pre-sarcopenia with all-cause mortality Chileans. Subjects Methods: Follow-up 2311 community-dwelling people ≥ 60y from Alexandros cohort. Anthropometric measurements, handgrip strength, mobility, physical performance tests were performed. Sarcopenia, pre-sarcopenia, severe defined using 2010...
Aging population has led to an increased prevalence of chronic and degenerative pathologies. A manifestation unhealthy aging is frailty, a geriatric syndrome that implies non-specific state greater vulnerability. Currently, methods for frailty diagnosis are based exclusively on clinical observation. The aim this study determine whether the bioenergetic capacity defined as mitochondrial oxygen consumption rate (OCR) peripheral circulation mononuclear cells (PBMC) associates with phenotype in...
Human thymocytes bearing T3 but neither T4 nor T8 antigens (T3+4-8- cells) were obtained after negative selection of thymocytes, either fresh or cultured in medium containing recombinant interleukin 2 (IL-2), by treatment with Na1/34, OKT4A and B9.4 monoclonal antibodies (which recognize T6, T4, antigens, respectively) complement. Quantitative flow cytometry showed a 98% pure population T3+4-8- lymphocytes, which included proliferating cells. The growth maturation requirements these...
Summary Background Neurocysticercosis (NC) is a parasitic disease of the central nervous system caused by larval stage Taenia solium . Although imaging studies are recommended for diagnosis and follow‐up patients, their high cost restricted availability limit use. Among various immunological tests, detection HP10 antigen in cerebral spinal fluid (CSF) has proved to be useful tool NC case viable but not dead parasites. Objectives This study was designed evaluate usefulness patients. Methods...
In this report, we have undertaken the phenotypic, functional and molecular characterization of a minor (less than 5%) subpopulation adult thymocytes regarded as earliest intrathymic T-cell precursors. Pro-T cells were immunoselected shown to express different hematopoietic cell markers (CD45, CD38, CD7, CD5) some activation-related molecules (4F2, Tr, HLA class II), but lack conventional T antigens (CD2-1-3-4-8-). TCR-gamma RNA messages are already expressed at early ontogenic stage, while...
In vivo, immunocompetent T lymphocytes are only detected late in ontogeny, among mature thymocytes expressing either T4 (L3T4 mouse) or T8 (Lyt-2) surface glycoproteins. We have previously shown, however, that there functional precursors T3+4-6-8- human vivo. Here we report on the vitro differentiation of prothymocytes into and cells. T11+3-4-6-8- (0.5% total thymocytes, greater than 98% pure) were obtained after treatment with OKT3 (T3), OKT4A (T4), Na1/34 (T6), B9.4 (T8) monoclonal...
Alkaline phosphatases (ALPase) (orthophosphoric-monoester phosphohydrolase, EC 3.1.3.1) are implicated in many biologic phenomena including ossification and differentiation of human neutrophils choriocarcinoma cells. Another trait, demonstrated by microinjection into Xenopus oocytes, is their ability to block the first mitotic division. Previous work our laboratory has established that ALPase also present on murine B lymphocytes activated either polyclonal mitogens or Th We have now...
The aim was to study the role of leptin in development dementia.Follow-up ALEXANDROS cohorts, with baseline measurements 2000. From 1,136 available subjects free dementia at baseline, 667 had frozen blood samples for measuring and soluble receptor (sOB-R). index (FLI) calculated as ratio sOB-R. Dementia defined an MMSE score <22 a >5 Pfeffer Activities Questionnaire.After 15 years follow-up, 42 incident cases were identified. No difference serum observed between people without dementia, but...
In Chile, depressive symptoms are highly prevalent among Chilean older adults, and research that examines the factors associated with them is scarce. This study aimed to determine if subjective assessments of quality life positive screen for adults enrolled in primary care Chile. The participants were people aged 70 years or more centers three cities. 15-item Geriatric Depression Scale was used symptoms. Multivariate logistic models associations. Overall, 17.28% men, 26.47% women (p = 0.003)...
Background: The assessment of frailty among older people could help to reduce its social and health burden.