A5032901243- Opioid Use Disorder Treatment
- Substance Abuse Treatment and Outcomes
- Cannabis and Cannabinoid Research
- Smoking Behavior and Cessation
- Behavioral Health and Interventions
- Obesity, Physical Activity, Diet
- Neurotransmitter Receptor Influence on Behavior
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Prenatal Substance Exposure Effects
- Treatment of Major Depression
- Forensic Toxicology and Drug Analysis
- Sleep and Wakefulness Research
- Sleep and related disorders
- Breastfeeding Practices and Influences
- Pain Management and Placebo Effect
- Alcoholism and Thiamine Deficiency
- Pain Management and Opioid Use
- Air Quality and Health Impacts
- Attention Deficit Hyperactivity Disorder
- Food Security and Health in Diverse Populations
- Neural and Behavioral Psychology Studies
- Focus Groups and Qualitative Methods
- Nicotinic Acetylcholine Receptors Study
- Alcohol Consumption and Health Effects
- Neurological and metabolic disorders
Johns Hopkins University
2019-2025
Johns Hopkins Medicine
2019-2025
Behavioral Pharma (United States)
2019-2025
National Institute on Drug Abuse
2021
University of Vermont
2014-2020
Pinney Associates (United States)
2020
Arizona State University
2019
Vermont Department of Health
2015-2017
A national policy is under consideration to reduce the nicotine content of cigarettes lower addiction potential in United States. To examine how smokers with psychiatric disorders and other vulnerabilities tobacco respond reduced content. multisite, double-blind, within-participant assessment acute response research ranging from levels below a hypothesized threshold those representative commercial (0.4, 2.3, 5.2, 15.8 mg/g tobacco) at 3 academic sites included 169 daily following vulnerable...
<h3>Importance</h3> While many individuals with opioid use disorder seek treatment at residential facilities to initiate long-term recovery, the availability and of medications for (MOUDs) in these is unclear. <h3>Objective</h3> To examine differences MOUD as a function Medicaid policy, facility-level factors associated availability, admissions-level use. <h3>Design, Setting, Participants</h3> This cross-sectional study used deidentified data from 2863 232 414 admissions United States 2017....
Increased orexin/hypocretin signaling is implicated in opioid withdrawal, sleep disturbances, and drug-seeking behaviors. This study examined whether a dual-orexin receptor antagonist would improve withdrawal outcomes when compared with placebo during buprenorphine/naloxone taper. Thirty-eight participants use disorder were recruited to clinical research unit maintained on 8/2 16/4 mg of treatment for 3 days before being randomized 20 suvorexant ( n = 14), 40 12), or 12); 26 individuals...
<h3>Importance</h3> This study is part of a programmatic effort evaluating the effects reducing nicotine content cigarettes to minimally addictive levels. <h3>Objective</h3> To examine whether very low-nicotine-content (VLNC) decrease smoking rates and dependence severity among smokers with psychiatric disorders or socioeconomic disadvantage. <h3>Design, Setting, Participants</h3> These 3 randomized clinical trials were performed at University Vermont, Brown University, Johns Hopkins between...
Background Opioid withdrawal can be expressed as both a spontaneous and precipitated syndrome. Although is well-characterized, there no operational definition of opioid withdrawal. Methods People ( N = 106) with use disorder maintained on morphine received 0.4 mg intramuscular naloxone completed self-report (Subjective Opiate Withdrawal Scale, SOWS), visual analog scale (VAS), Bad Effects Sick, observer ratings (Clinical COWS). Time to peak severity minimal clinically important difference...
Abstract There is limited data on the comparative pharmacokinetics of cannabidiol (CBD) across oral and vaporized formulations. This within-subject, double-blind, double-dummy, placebo-controlled laboratory study analyzed pharmacokinetic profile CBD, ∆9-tetrahydrocannabinol (∆9-THC) related metabolites in blood fluid (OF) after participants (n = 18) administered 100 mg CBD each following formulations: (1) (2) (3) CBD-dominant cannabis containing 10.5% 0.39% ∆9-THC (3.7 mg); all also...
Abstract Preclinical and epidemiological evidence supports that cannabinoids may have opioid-sparing properties could be one strategy to decrease opioid use associated harms like overdose extramedical use. The objective of this within subjects, double-blind, double-dummy, randomized human laboratory trial was examine whether cannabidiol (CBD) increases analgesic effects there are corresponding in other mediated effects. Healthy participants (N = 31) attended 5 outpatient sessions where they...
Delta-8-tetrahydrocannabinol (Δ8-THC) has emerged as a new retail cannabinoid product in the U.S. This study queried Δ8-THC users about use characteristics and self-reported drug effects. Participants were recruited via large online crowdsourcing platform (Amazon Mechanical Turk). Adults (N = 252) with past year (35% at least weekly use) completed surveys open-ended questions related to their reasons for using experiences Δ8-THC-containing products. of Δ9-tetrahydrocannabinol (Δ9-THC) and/or...
Breastfeeding is associated with substantial benefits for both the child and mother. Most guidelines state that women who use illicit drugs should not breastfeed. Although this recommendation has traditionally included marijuana, drug's changing legal status limited scientific research regarding marijuana's effect on breastfeeding nursing may lead to varying recommendations made by lactation professionals clients marijuana. Additionally, our knowledge, there are no data estimating prevalence...
Abstract Allelic variations in the A118G SNP of OPRM1 gene change opioid signaling; however, evaluations how allelic differences may influence effects are lacking. This human laboratory paradigm examined whether AA versus AG/GG genotypes determined response profiles. Individuals with limited exposure (N = 100) completed a five‐day within‐subject, double‐blind, placebo‐controlled, residential study. Participants were admitted (Day 1), received 4 mg hydromorphone 2) and 0 mg, 2 8 randomized...
Background The assessment of drug craving is common in survey studies, including those using real-time data collection methods, such as Ecological Momentary Assessment (EMA). However, few studies investigate how participants with chronic pain interpret the word 'craving' and interpretations impact responses.