A5041044203- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Single-cell and spatial transcriptomics
- Glioma Diagnosis and Treatment
- Synthesis and Catalytic Reactions
- bioluminescence and chemiluminescence research
- Microtubule and mitosis dynamics
- Cancer, Stress, Anesthesia, and Immune Response
- Brain Metastases and Treatment
- 3D Printing in Biomedical Research
- Anesthesia and Neurotoxicity Research
- Ocular Oncology and Treatments
- RNA Research and Splicing
- Click Chemistry and Applications
- Melanoma and MAPK Pathways
German Cancer Research Center
2019-2022
Heidelberg University
2019-2022
University Hospital Heidelberg
2019-2021
National Center for Tumor Diseases
2019-2021
Brain metastases (BM) are a frequent complication of malignant melanoma (MM), with limited treatment options and poor survival. Prevention BM could be more effective better tolerated than treating established in various conditions.
Abstract Background Patients developing brain metastasis (BM) still face a poor survival due to limited treatment options. BM prevention using low dose drug schedules could be more potent strategy with less side effects than treating established BM. This add real benefit the ongoing challenge of facing frequent formation in high-risk malignant melanoma (MM) patients. Methods Aiming study dynamics PI3K/Akt/mTOR (PAM) pathway activation during metastatic cascade, vivo molecular imaging an Akt...
Abstract A network of communicating tumour cells established by microtubes (TMs) is supposed to mediate relevant aspects progression and resistance incurable gliomas. Moreover, neuronal activity has been shown foster malignant behavior glioma non-synaptic paracrine autocrine mechanisms. Here, we report an unexpected direct communication channel between neurons in multiple disease models as well astrocytomas glioblastomas (GBs) adult patients: functional bona fide chemical synapses formed...
Abstract BACKGROUND Gliomas are incurable brain tumors characterized by their infiltrative growth which makes them a whole-brain disease. Previously we described membrane protrusions called tumor microtubes (TMs), and glutamatergic synapses between neurons glioma cells, as mechanisms contributing to cell invasion progression. However, the interrelation of two, exact dynamics over time was unknown. Therefore, investigate neuronal synaptic input on TM-associated motility. MATERIAL AND METHODS...
Abstract Incurable gliomas are characterized by their infiltration into the whole brain. Recently, we described tumor microtubes as a novel structure contributing to glioma cell invasion and uncovered synaptic contacts on cells that drive brain tumour progression. However, exact effects of neuronal activity motility yet unclear. Here, show how recently neuronal-like cellular transcription state glioblastoma is correlated in vivo. To unravel details features space time, established approach...