Cedric Tehranian
A5039139390- Cancer Cells and Metastasis
- Barrier Structure and Function Studies
- Nanoplatforms for cancer theranostics
- Ferroptosis and cancer prognosis
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Brain Metastases and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- bioluminescence and chemiluminescence research
- Neuroscience and Neuropharmacology Research
- Lung Cancer Research Studies
- Melanoma and MAPK Pathways
- Ocular Oncology and Treatments
- S100 Proteins and Annexins
- Synthesis and Catalytic Reactions
- Click Chemistry and Applications
- Glioma Diagnosis and Treatment
German Cancer Research Center
2020-2024
Heidelberg University
2020-2023
National Center for Tumor Diseases
2020
University Hospital Heidelberg
2020
Crossing the blood-brain barrier is a crucial, rate-limiting step of brain metastasis. Understanding mechanisms cancer cell extravasation from microcapillaries limited as underlying cellular and molecular processes cannot be adequately investigated using in vitro models endpoint vivo experiments. Using ultrastructural functional imaging, we demonstrate that dynamic changes activated promote mandatory first steps colonization. Successful arrested cells occurred when adjacent capillary...
Brain metastases (BM) are a frequent complication of malignant melanoma (MM), with limited treatment options and poor survival. Prevention BM could be more effective better tolerated than treating established in various conditions.
lnteractions between neurons and cancer cells are found in many malignancies, but their relevance for metastatic organ colonization remain largely unknown. It is also unclear whether any direct synaptic communication of non-neural tumor types exists, if so, this can support metastasis thus progression. Here we show that excitatory synapses formed brain-metastatic melanoma breast cells. This starts at an early microscopic stage after extravasation into the brain parenchyma, during residence...
<p>Supplementary Movie 4</p>
<p>Supplementary Movie 5</p>
<p>Supplementary Movie 4</p>
<p>Supplementary Movie 3</p>
<p>Supplementary Movie 2</p>
<p>Supplementary Movie 2</p>
<p>Supplementary Movie 3</p>
<p>Supplementary Movie 1</p>
<p>Supplementary Movie 6</p>
<p>Supplementary Movie 6</p>
<p>Supplementary Figures and Figure legends, Supplementary Video legends supplementary materials methods</p>
<p>Supplementary Movie 1</p>
<p>Supplementary Figures and Figure legends, Supplementary Video legends supplementary materials methods</p>
<p>Supplementary Movie 5</p>
Abstract Background Patients developing brain metastasis (BM) still face a poor survival due to limited treatment options. BM prevention using low dose drug schedules could be more potent strategy with less side effects than treating established BM. This add real benefit the ongoing challenge of facing frequent formation in high-risk malignant melanoma (MM) patients. Methods Aiming study dynamics PI3K/Akt/mTOR (PAM) pathway activation during metastatic cascade, vivo molecular imaging an Akt...
<div>Abstract<p>Crossing the blood-brain barrier is a crucial, rate-limiting step of brain metastasis. Understanding mechanisms cancer cell extravasation from microcapillaries limited as underlying cellular and molecular processes cannot be adequately investigated using in vitro models end-point vivo experiments. Using ultrastructural functional imaging, we demonstrate that dynamic changes activated promote mandatory first steps colonization. Successful arrested cells occurred...
<div>Abstract<p>Crossing the blood–brain barrier is a crucial, rate-limiting step of brain metastasis. Understanding mechanisms cancer cell extravasation from microcapillaries limited as underlying cellular and molecular processes cannot be adequately investigated using <i>in vitro</i> models endpoint vivo</i> experiments. Using ultrastructural functional imaging, we demonstrate that dynamic changes activated promote mandatory first steps colonization....
<p>Supplementary Movie 6</p>
<p>Supplementary Movie 2</p>
<p>Supplementary Figures and Figure legends, Supplementary Video legends supplementary materials methods</p>
<p>Supplementary Movie 3</p>