A5068225201- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Esophageal Cancer Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- Neutropenia and Cancer Infections
- Cardiac Arrest and Resuscitation
- Multiple and Secondary Primary Cancers
- Acute Lymphoblastic Leukemia research
- Intestinal Malrotation and Obstruction Disorders
- Hernia repair and management
- Congenital Anomalies and Fetal Surgery
- Occupational and environmental lung diseases
- Helicobacter pylori-related gastroenterology studies
- Pediatric Hepatobiliary Diseases and Treatments
- Colorectal Cancer Treatments and Studies
- Clinical Nutrition and Gastroenterology
- Pancreatic and Hepatic Oncology Research
- Cardiovascular and exercise physiology
- Lung Cancer Diagnosis and Treatment
- Appendicitis Diagnosis and Management
- Pelvic and Acetabular Injuries
- Heart Rate Variability and Autonomic Control
Nagoya University
1995-2024
Aichi Cancer Center
2023
National Cancer Center Hospital East
2017-2021
Sendai Kousei Hospital
2020
Abstract Purpose A high risk of febrile neutropenia (FN) from neoadjuvant chemotherapy with docetaxel, cisplatin, and fluorouracil (DCF) for esophageal cancer has been reported. The optimal timing prophylactic use pegfilgrastim remains to be elucidated. To evaluate the effect administered on day 3, we conducted a feasibility study. Methods Chemotherapy consisted intravenous administration docetaxel (70 mg/m 2 per day) cisplatin 1 continuous infusion 5‐fluorouracil (750 days 1–5....
The role of para-aortic lymph node (PALN) dissection for far-advanced gastric cancer is controversial in patients with clinical PALN positivity who have responded to chemotherapy.We retrospectively analyzed long-term outcomes pathologically-positive PALNs underwent radical gastrectomy.The 3- and 5-year overall survival (OS) rates 65 pathologically PALN-positive (n=704) were 33.8% 21.2%, respectively. Multivariable analysis revealed the following poor prognostic factors: nodal involvement...
Abstract Background and Objectives The lymphatic flow around the esophagogastric junction is complicated. Therefore, it unclear whether invasion in esophageal region (eLI) gastric (gLI) patients with adenocarcinoma of (AEG) equally affect incidence lymph node metastases (LNM), consequently, survival. Methods We retrospectively reviewed clinicopathological data 175 AEG between January 2008 July 2017. Risk factors for LNM impacts eLI or gLI on survival outcomes were investigated. Results was...
Abstract Gastric stump cancer (GSC) has distinct clinicopathological characteristics from primary gastric cancer. However, the detailed molecular and pathological of GSC remain to be clarified because its rarity. In this study, a set tissue microarrays 89 patients was analysed by immunohistochemistry in situ hybridisation. Programmed death ligand 1 (PD-L1) expressed 98.9% tumour-infiltrating immune cells (TIICs) 6.7% tumour (TCs). Epstein–Barr virus (EBV) detected 18 (20.2%). Overexpression...
This retrospective study examined early the predictive factors for successful conversion surgery (CS) with R0 resection in patients metastatic gastric cancer (MGC) who underwent systemic chemotherapy. included 204 diagnosed adenocarcinoma, received chemotherapy between 2009 and 2019. Of these patients, 31 (15%) CS resection. The incidence of was not affected by volume lesions or presence peritoneal metastasis. overall survival time group significantly longer than that non-CS (hazard ratio,...
The role of nodal station No. 14v (along the superior mesenteric vein) in lymphadenectomy for distal gastric cancer remains elusive. A 73-year-old woman underwent endoscopic submucosal dissection cancer, and was referred to our division additional surgery because pathologically non-curative resection. laparoscopic gastrectomy with D1+ performed, a final diagnosis pT1bN1M0, Stage IB (2 metastases 6). Four months post-surgery, abdominal computed tomography revealed 14-mm solitary nodule along...
In Japan, systemic chemotherapy is the standard treatment for unresectable, advanced, or recurrent gastric cancer. However, numerous patients with cancer do not receive late-line because of rapid progression Additionally, treatments, such as nivolumab, trifluridine tipiracil (FTD/TPI), irinotecan, have limited effects on improving clinical symptoms and delaying onset associated progression. Recently, a combination FTD/TPI ramucirumab was reported to high response rate in treatment; however,...
We herein report a rare case of gastric cancer with adult intestinal malrotation successfully treated by laparoscopic total gastrectomy (LTG) considering an adequate design Roux-en-Y reconstruction. A 67-year-old man cStage IV advanced had been platinum-fluoropyrimidine chemotherapy and was eventually down-staged to ycStage I; thus, radical resection planned. During the exploration in staging laparoscopy, non-rotation type incidentally found. LTG D2 dissection employed followed Because...
The present study aimed to assess the feasibility of global standard chemoradiotherapy (CRT) followed by surgery in patients with esophageal cancer. A prospective was conducted at Nagoya University Hospital (Nagoya, Japan) evaluate CRT regimen consisted 75 mg/m<sup>2</sup> cisplatin on day 1 and 1,000 fluorouracil daily days 1‑4 given twice 4 weeks apart together concurrent irradiation starting (group A). For comparison, 17 cancer who had received same chemotherapy but lower drug doses were...
Journal of Cancer Metastasis and Treatment is an open access journal, focusing on basic clinical studies related to cancer cell, cell biology, oncology, radiation therapy radiology, obstetrics gynecology, pediatrics, surgery, hematology, neuro-oncology, etc.
Anastomotic leakage (AL) is one of the most critical postoperative complications after subtotal esophagectomy in patients with esophageal cancer. This study attempted to develop an optimal scoring system for stratifying risk AL.The included 171 who underwent cancer followed by esophagogastrostomy cervical region from January 2011 April 2021 at Nagoya University Hospital. AL was defined radiologic or endoscopic evidence anastomotic breakdown using some modalities. A early diagnosis...
Abstract Purpose. Anastomotic leakage (AL) is one of the most critical postoperative complications after subtotal esophagectomy in patients with esophageal cancer. This study attempted to develop an optimal scoring system for stratifying risk AL. Methods. The included 171 who underwent cancer followed by esophagogastrostomy cervical region from January 2011 April 2021 at Nagoya University Hospital. AL was defined radiologic or endoscopic evidence anastomotic breakdown using some modalities....
158 Background: The prognosis of patients with advanced gastric cancer para-aortic lymph node (PAN) involvement is poor. We retrospectively investigated the prognostic factors for PAN involvement. Methods: who underwent radical gastrectomy dissection between 1992 and 2014 in our institution included this study. clinicopathological features identified pathologically after curative were analyzed. Results: In period, a total 704 65 as positive eligible Total combined resection other organs...
177 Background: The incidence of Siewert type II adenocarcinoma the esophagogastric junction (AEG II) has been increasing in East, and total gastrectomy (TG) a standard treatment procedure. However, it is reported that distal perigastric lymph node (LN) metastasis low, thus proximal (PG) could be option. aim this study was to demonstrate oncological safety PG for patients with AEG II. Methods: This included 99 who underwent lower esophagectomy from Jan. 2008 June 2017. Patients esophageal...
179 Background: The incidence of GSC is expected to increase as the survival outcome following gastrectomy for gastric cancer improves. Considering poor tolerability postoperative adjuvant chemotherapy after completion total gastrectomy, neoadjuvant (NAC) a plausible treatment strategy GSC, but it unclear which clinical factors should make patients candidates NAC, due lack studies investigating relationship between and outcome. aim this study was review preoperative prognostic identify...