A5077117058- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Salivary Gland Tumors Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Ear and Head Tumors
- Tracheal and airway disorders
- Oral and Maxillofacial Pathology
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- Colorectal Cancer Treatments and Studies
- Head and Neck Anomalies
- Esophageal Cancer Research and Treatment
- Genetic factors in colorectal cancer
- Vascular anomalies and interventions
- Head and Neck Surgical Oncology
- Surgical site infection prevention
- Epigenetics and DNA Methylation
- Bone Tumor Diagnosis and Treatments
- IgG4-Related and Inflammatory Diseases
- Hernia repair and management
- Infectious Diseases and Tuberculosis
- Neuroendocrine Tumor Research Advances
- Soft tissue tumor case studies
Jichi Medical University
2012-2024
Jichi Medical University Saitama Medical Center
2013-2024
Jichi Medical University Hospital
2021
National Cancer Center Hospital East
2017
Himeji Red Cross Hospital
2011-2014
Gunma University
1978
Background Liquid biopsies enable the detection of circulating tumor DNA (ctDNA). However, clinical significance KRAS-mutated ctDNA for pancreatic cancer has been inconsistent with respect to its prognostic and predictive potential. Methods findings A total 422 blood samples were collected from 78 patients undergoing treatments localized metastatic ductal adenocarcinoma. KRAS mutation in tissues levels plasma determined by RASKET droplet digital polymerase chain reaction. Longitudinal...
Mesenteric leiomyosarcoma is a rare disease with poor prognosis. Previously, mesenteric was not differentiated from gastrointestinal stromal tumor (GIST), which the most common mesenchymal of tract, and several cases GIST may have been misclassified as leiomyosarcoma. Thus, actual clinicopathological characteristics leiomyosarcomas remain unclear. We herein describe case arising in descending mesocolon patient who developed metachronous liver metastasis. A 76‑year‑old woman reported mass her...
Pseudomembranous colitis is known to be caused by Clostridium difficile; and, in 3% 8% of patients, it lapses into an aggressive clinical course that described as fulminant. We present here a case extremely rapid and fatal fulminant pseudomembranous developed after ileostomy closure, minor surgical procedure. To the best our knowledge, this first report closure diversion adult. A 69-year-old Japanese man, who had previously undergone low anterior resection creation diverting for stage III...
Genome‑wide DNA hypomethylation is the most common molecular feature in human cancers associated with chromosomal instability (CIN), which involved mechanisms that regulate pancreatic cancer (PC) metastasis. It was investigated whether genome‑wide affects phenotype PC via CIN vitro, and its significance on biological behavior of verified. The relative demethylation level (RDL) long interspersed nucleotide element‑1 (LINE‑1) cell lines used to characterize using methylation‑specific...
We herein describe the case of an adult with a complicated huge lymphangioma small bowel mesentery. Computed tomography (CT) confirmed 45 × 30 14 cm multiple and separate, mixed solid cystic tumor without enhancement by contrast medium in abdominal cavity. Mesenteric CT angiography three-dimensional (3D) reconstruction showed that did not involve first jejunal artery, although subsequent ileal arteries corresponding segment bowel. Under anatomic guidance based on mesenteric 3D...
The role of para-aortic lymph node (PALN) dissection for far-advanced gastric cancer is controversial in patients with clinical PALN positivity who have responded to chemotherapy.We retrospectively analyzed long-term outcomes pathologically-positive PALNs underwent radical gastrectomy.The 3- and 5-year overall survival (OS) rates 65 pathologically PALN-positive (n=704) were 33.8% 21.2%, respectively. Multivariable analysis revealed the following poor prognostic factors: nodal involvement...
Despite the acceptance of carbohydrate antigen 19-9 (CA19-9) as a valuable predictor for prognosis pancreatic ductal adenocarcinoma (PDAC), its cutoff value remains controversial. Our previous study showed significant correlation between CA19-9 levels and presence KRAS-mutated ctDNA in blood patients with PDAC. Based on this correlation, we investigated optimal before surgery. Continuous values ctDNAs were monitored 22 unresectable PDAC who underwent chemotherapy 2015 2017. Receiver...
The role of nodal station No. 14v (along the superior mesenteric vein) in lymphadenectomy for distal gastric cancer remains elusive. A 73-year-old woman underwent endoscopic submucosal dissection cancer, and was referred to our division additional surgery because pathologically non-curative resection. laparoscopic gastrectomy with D1+ performed, a final diagnosis pT1bN1M0, Stage IB (2 metastases 6). Four months post-surgery, abdominal computed tomography revealed 14-mm solitary nodule along...
Combined treatment with bevacizumab and trifluridine/tipiracil (TAS-102) leads to an increased chance of survival in patients refractory metastatic colorectal cancer (mCRC); however, this is associated frequency severe neutropenia (number neutrophils <1,000), which should ideally be managed without dose delays. The present study provided a retrospective review 35 mCRC, aimed elucidate the benefits prophylactic pegfilgrastim for neutropenia. Patients received TAS-102 (35 mg/m2) orally twice...
Abstract Overexpression of satellite RNAs in heterochromatin induces chromosomal instability (CIN) through the DNA damage response and cell cycle checkpoint activation. Although may be therapeutic targets, associated mechanisms underlying drug sensitivity are unknown. Here, we determined whether reflect to topoisomerase I inhibitor camptothecin (CPT) via CIN induction. We constructed retroviral vectors expressing major control viruses, infected microsatellite stable mouse colon cancer cells...
Pneumoparotitis is rare. We report a case of pneumoparotitis in 7-year-old boy that was related to subcutaneous emphysema. The reported left cheek swelling. Computed tomography (CT) showed expanding emphysema, and crepitation heard the parotid region. A detailed interview revealed his "inflatable mouth" habit, which we diagnosed as advised him avoid increasing intraoral pressure administered antibiotics help prevent infection. Symptoms were alleviated within few days. concluded could be by...
Nivolumab monotherapy is a standard treatment of metastatic gastric cancer, and this type cancer involves vascular endothelial growth factor (VEGF) signaling in the tumor immunological environment. The subgroup analysis ATTRACTION‑2 trial revealed that prior with ramucirumab (RAM), VEGF inhibitor, affected therapeutic effect nivolumab. present retrospective study aimed to review patients who were treated paclitaxel (PTX) RAM followed by A total 29 PTX + as second‑line treatment, nivolumab...
385 Background: Despite success in the HER2 targeted therapies for metastatic gastric cancer patients, conventional assessment of status tumor tissue specimens is still under debate. Methods: Twenty-seven patients with were treated according to histological status. On-chip sorting system was used isolation circulating cells (CTCs) before treatments. Epithelial mesenchymal transition (EMT) assessed by vimentin and cytokeratin. DNA extracted from CTCs applied gene panel 409 related genes. The...
Abstract Background The recent guidelines from the European and American Hernia Societies recommend a continuous small-bite suturing technique with slowly absorbable sutures for fascial closure of midline abdominal wall incisions to reduce incidence wound complications, especially incisional hernia. However, this is based on low-certainty evidence. We could not find any recommendations skin closure. an important determinant risk comprehensive approach prevent complications should be...
We report a rare case of adult intussusception caused by an inverted Meckel's diverticulum with ectopic pancreatic tissue. A 43-year-old woman was referred to our hospital complaints abdominal distention, intermittent pain and nausea that she experienced 3 months ago. Abdominal computed tomography scans demonstrated ileo-ileal contained tumor fat density as the lead point. Laparoscopic-assisted partial resection small intestine performed. The surgical specimen showed elongated polypoid...
Laparoscopic surgery for obstructive colorectal carcinoma is a controversial issue. Defining the as colonoscopic impassability, patients with were managed according to treatment algorithm, by which indication of open or laparoscopic was determined. As result, 31 underwent surgery. The location tumor in right side 10 and left 21 patients. Preoperatively, all cases restriction oral intake and/or decompression. completed 26 colonic obstruction direct cause conversion only 1 case. Regarding...
Journal of Case Reports in Medicine,2012,1,1,1-4.Published:June 2012Type:Case ReportAuthors:Tomoyasu Tachibana, Kazunori Nishizaki, Masayoshi Fujisawa, Yuya Ogawara, Yuko Matsuyama, Iku Abe, and Michihiro Nakada Author(s) affiliations:Tomoyasu Tachibana,1 Nishizaki,2 Fujisawa,3 Ogawara,1 Matsuyama,1 Abe,1 Nakada4 1Department Otolaryngology, Himeji Red Cross Hospital, 12-1 Shimoteno 1-Chome, City, Hyogo 670-8540, JAPAN. 2Department Okayama University Graduate School Medicine, Dentistry...
Abstract Gastric and bile acid reflux leads to chronic inflammation, resulting in methylation alterations Barrett’s esophagus (BE) together with chromosomal instability (CIN). We investigated DNA hypomethylation following exposure confirmed its significance BE-related carcinogenesis by inducing CIN vitro. OACP4C, an esophageal cancer cell line, CP-A, a non-dysplastic line originating from BE, were exposed acidic conditions using deoxycholic acid. CP-A exhibited substantially increased of...
We describe an extremely rare case of tracheal stenosis caused by unnoticed microscopic fiber-like foreign bodies. A 66-year-old woman complained dyspnea with inspiratory stridor. Magnifying electroendoscopy and computed tomography revealed involving the entire circumference lumen. Tracheotomy biopsy were performed. Histologically, lesion showed chronic inflammation a deposition The patient had no history trauma or inhalation injury, but undergone intratracheal intubation on 4 occasions. was...