Background: Normal pregnancy and the postpartum period are characterized by thrombotic predisposition. Consequently, monitoring coagulation markers conducting risk assessments essential in preventing events that negatively impact both mother child. In medical practice, fibrinogen/fibrin degradation products (FDPs) main currently investigated pregnancy. Methods: We proteins C S, antiphospholipid antibodies (APLs), human factor V, beta-2-glycoprotein 1 or apolipoprotein H (APOH) levels to...

This study evaluated the differential expression of four placental markers—vitamin D receptor (VDR), Cluster Differentiation 44 (CD44), osteopontin (OPN), and cyclooxygenase-2 (COX-2)—in response to pathogens, which may contribute our understanding pathogen-specific impacts on pregnancy outcomes. We immunohistochemically (IHC) analyzed tissues obtained from 70 healthy-term pregnant women in control group compared them 78 with above 24 weeks gestation, single-pathogen vaginal infection,...

Background: Despite being a very well-documented subject in the literature, there are still conflicting results regarding teenage pregnancies and their fetal outcomes. Methods: We conducted retrospective, comparative cohort study that included 1082 mothers aged less than 18 years, compared to 41,998 over who delivered our tertiary referral center between January 2015 December 2021. To check for significant differences two groups, chi-qquared or Fisher’s test categorical variables were used....

Background: The most commonly known cardiac effect of gestational diabetes mellitus (GD) in the fetus is hypertrophic cardiomyopathy, but recent studies show that it preceded by subclinical dysfunction. This study aimed to assess GD on fetal geometry and contractility two-dimensional speckle-tracking technology. Methods: We performed a prospective observational included 33 pregnant patients with 30 healthy individuals. For all fetuses, four-chamber 3 s cine-loop was recorded analyzed Fetal...

Chorioamnionitis or intra-amniotic infection is an that affects the intrauterine content during pregnancy. Numerous studies have reported vaginal colonization with various types of infectious agents as a risk factor for chorioamnionitis. Although this complication occurs due to ascending polymicrobial bacterial at time membrane breakage, it may also occur in pregnant women intact membranes, mainly Ureaplasma urealyticum (U. urealyticum) and Mycoplasma hominis (M. hominis). The main aim...

(1) Background: In the context of COVID-19 pandemic, educational system in Romania faced major challenges. Online knowledge development was necessary and mandatory during this time; (2) Methods: our study included a group 140 preadolescents used phenomenology qualitative method to investigate if novel online teaching, implemented hurry pandemic without any previous teacher training, managed replace face-to-face teaching; (3) Results: The students have expressed their joy for courses, as long...

Cervical cancer is rare in adolescent and pediatric populations, with adenocarcinoma being the most commonly reported. Clear cell of uterine cervix accounts for only 4% all cases, about two-thirds are associated intrauterine diethylstilbestrol (DES) exposure. We report case a 14-year-old virgin girl who presented 1-month-long history abnormal vaginal bleeding lower abdominal pain. Transabdominal pelvic ultrasound examination revealed presence an irregular, homogeneous cervical mass that was...

A major myomectomy-associated problem is excessive blood loss. The aim of the present study was to evaluate effect glypressin on loss during laparoscopic myomectomy (LM) in women with uterine myomas. total 188 scheduled for LM myomas were divided into two groups. one group (n=64) received a 5-ml intramyometrial injection 0.2 mg/ml (glypressin group; 1). other (n=124) (group 2) had an performed without any method reduce decrease postoperative hemoglobin (Hb), hematocrit (Ht), morbidity and...

A common problem in gynecological practice is the differential diagnosis of ovarian masses. The clinician must apply IOTA (International Ovarian Tumor Analysis) ADNEX (Assessment Different Neoplasia Adnexa) model criteria to evaluate risk benign, borderline or malignant tumors. aim this study was verify if a practical tool be used before surgery and there significant difference between histological findings. prospective single center performed January 2017 December 2019 Obstetrics Gynecology...

Background and Objectives: Although frequent associated with high mortality morbidity rate, congenital heart disease (CHD) has a suboptimal prenatal detection significant variation according to the scanning protocol. The aim of this study was evaluate role 3-vessels trachea view (3VT) in detecting CHD, or without use Color Doppler, an emphasis on major CHD. Materials Methods: We performed retrospective 1596 unselected pregnant patients presenting at 11-37 weeks gestation for routine anomaly...

(1) Background: The three factors within the Virchow triad play leading role in development of deep vein thrombosis (DVT) during pregnancy. (2) Methods: This research approaches various risk associated with DVT and its most representative complications, pulmonary thromboembolism cerebral venous thrombosis, pregnant postpartum women across a 15-year period (2007–2021). (3) Results: A total 201 out 287 patients had factors, while 86 did not present any. Out 47 developed thromboembolism, 12...

: We investigated the expression of inflammation, placental development, and function markers, including cluster differentiation 44 (CD44), osteopontin (OPN), cyclooxygenase-2 (COX-2), to shed light on controversy regarding impact COVID-19 epidemic fetal development pregnancy outcomes.

The trophoblast is a significant source of vitamin D synthesis during pregnancy, with the literature suggesting its role in fetal growth. We aim to underline possible mechanism that would explain negative outcomes COVID-19-positive mothers by examining relationship between altered placental structure and function throphoblast cells' receptor levels.

(1) Background: To investigate the effect of phosphohistone H3 (PHH3) and vitamin D receptor (VDR) in risk assessment endometriosis, two cohorts women with this pathology, those receiving hormonal treatment, without treatment; (2) Methods: In 60 cases paraffin-embedded endometriosis tissue samples, retrieved after surgery, were immunohistochemically (IHC) analyzed aiming to determine expression status PHH3 VDR; (3) Results: The IHC positive index VDR these groups compared. levels positively...

(1) Background: The effects of serum vitamin D levels, the receptor (VDR), and phosphohistone H3 (PHH3) in endometriosis were investigated two cohorts women with this pathology: those receiving hormonal treatment without treatment. (2) Methods: In 60 cases (26 progestin 34 without), paraffin-embedded tissue samples retrieved after surgery immunohistochemically (IHC) analyzed to determine expression statuses VDR PHH3. addition, levels 25(OH) assessed for each patient. (3) Results: evaluations...

(1) Background: the worldwide impact of overweight and obesity is rising, increasingly resembling an epidemic (a price we have to pay for our new way living). (2) Methods: study aims evaluate temporal trends patterns singleton pregnant women's BMI (body mass index) in region during a 12-year time frame between 2010 2021. (3) Results: We noticed statistically significant difference BMIs nulliparous multiparous women significantly increased pregestational with previous ART (assisted...

Endometriosis is a relatively frequent pathology in gynecological practice. We performed an analysis to demonstrate the molecular changes that occur endometriosis synthetic progestin-treated patients, hoping sketch possible pathophysiological pathway will help us better understand and treat this debilitating disease. conducted prospective study included group of 40 women, evaluated our hospital between 2020-2021. immunohistochemical tissue expression estrogen receptor (ER), progesterone...

Human immunodeficiency virus (HIV) infection cannot be completely eliminated from the body because integrates its genetic code into that of host cell. The prevalence pregnancy in women with HIV has increased due to efficacy antiretroviral therapy (ART). Placental insufficiency is associated a reduction blood flow and circulatory redistribution, resulting fetal hypoxia nutrient deprivation as consequence an altered placental function, it can result lower birthweight. aim study was determine...

Atrial septal aneurysm (ASA) is a rarely reported fetal finding. Its definition variable, but the diagnosis usually made when foramen ovale flap extends at least halfway across left atrium. It considered transient, self-limiting condition, on occasion, it can be complicated by arrhythmia or ventricular (LV) inflow obstruction-if longstanding, this lead to heart hypoplasia. We present two cases of ASA diagnosed second trimester scan, one which was subsequently LV obstruction and prenatal...

The present study reported a case of uterine leiomyoma with an unusual growth pattern featuring areas intravascular leiomyomatosis, rarely described in the international literature available English. It presented 44-year-old woman who, fearing Covid-19 outbreak, postponed recommended surgical intervention to remove leiomyoma. two-year delay worsened symptoms, doubled size tumor, and facilitated development leiomyomatosis. was possible establish correct diagnosis only after histopathological...

Myomas are the most common benign uterine tumors in women of childbearing age, with an incidence up to 77% and a major impact on women's health. The aim our study was provide information concerning prevalence myomas patients admitted tertiary referral center Northeastern Romania. This retrospective conducted at Iasi 'Cuza Voda' University Hospital Obstetrics Gynecology (Romania) included 11,538 patients, representing all gynecology department between January 2013 December 2019. During...

(1) Generating the need to impose social distancing reduce spread of virus, COVID-19 pandemic altered ways in which teaching process normally happens. The aim our study was determine impact online on medical students during this period. (2) Our included 2059 medical, dental and pharmacy from University Medicine Pharmacy "Grigore T. Popa", Iasi, Romania. We used a modified metacognition questionnaire after translation into Romanian validation. 38 items, it divided four parts. Academic results...

Although the rates of adolescent pregnancies appear to have dropped according World Health Organization (WHO), decrease in age first menarche and better nutrition seems contribute otherwise high rate pregnancy worldwide, despite efforts different organizations improve upon this trend. We conducted a population-based retrospective cohort study from January 2015 December 2021 using our hospitals' database. totaled 2.954 6.802 adult pregnancies. First, we compared younger adolescents' outcomes...