A5071416796- Gut microbiota and health
- Diabetes Management and Education
- Diet and metabolism studies
- Tuberculosis Research and Epidemiology
- Genomics and Phylogenetic Studies
- Bioinformatics and Genomic Networks
- Microbial Community Ecology and Physiology
- RNA and protein synthesis mechanisms
- Clostridium difficile and Clostridium perfringens research
- vaccines and immunoinformatics approaches
- Brucella: diagnosis, epidemiology, treatment
- Algorithms and Data Compression
- COVID-19 Clinical Research Studies
- Microbial Metabolic Engineering and Bioproduction
- Astronomical Observations and Instrumentation
- Salmonella and Campylobacter epidemiology
- Infant Development and Preterm Care
- Protein Structure and Dynamics
- Neonatal Respiratory Health Research
- Metabolomics and Mass Spectrometry Studies
- Food Security and Health in Diverse Populations
- SARS-CoV-2 and COVID-19 Research
- Heat shock proteins research
- Animal Disease Management and Epidemiology
- Bacteriophages and microbial interactions
Western Washington University
2024
University of Washington
2024
Tata Consultancy Services (India)
2014-2023
Creative Commons
2023
L V Prasad Eye Institute
2023
Hi-Tech Medical College & Hospital
2023
ICAR Research Complex for NEH Region
2016-2021
North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences
2020
Silchar Medical College and Hospital
2020
Employees' State Insurance Model Hospital
2020
Abstract Background Type 2 diabetes (T2D), a multifactorial disease influenced by host genetics and environmental factors, is the most common endocrine disease. Several studies have shown that gut microbiota as close-up mediator influences physiology including metabolism. The aim of present study to examine compositional functional potential across individuals from Denmark South India with focus on T2D. Many earlier investigated microbiome aspects T2D, it has also been anticipated such...
Availability of genome sequences pathogens has provided a tremendous amount information that can be useful in drug target and vaccine identification. One the recently adopted strategies is based on subtractive genomics approach, which subtraction dataset between host pathogen provides for set genes are likely to essential but absent host. This approach been used successfully recent times identify Pseudomonas aeruginosa. We have same methodology analyse whole sequence human gastric...
Dysbiosis in the gut microbiome has been implicated several diseases including auto-immune diseases, inflammatory cancers and mental disorders. Keratitis is an disease of eye significantly contributing to corneal blindness developing world. It would be worthwhile investigate possibility dysbiosis being associated with Keratitis. Here, we have analyzed fungal bacterial populations stool samples through high-throughput sequencing ITS2 region for fungi V3-V4 16S rRNA gene bacteria healthy...
Preterm birth is a leading cause of global neonate mortality. Hospitalization costs associated with preterm deliveries present huge economic burden. Existing physical/biochemical markers for predicting risk are mostly suited application at mid/late pregnancy stages, thereby leaving very short time (between diagnosis and delivery) adopting appropriate intervention strategies. Recent studies indicating correlations between pre/full-term delivery the composition vaginal microbiota in pregnant...
Abstract Background Recent studies have indicated an association of gut microbiota and microbial metabolites with type 2 diabetes mellitus (T2D). However, large-scale investigation the “prediabetic” (PD) subjects has not been reported. Identifying robust microbiome signatures prediabetes characterizing early prediabetic stages is important for understanding disease development could be crucial in diagnosis prevention. Methods The current study performed amplification sequencing on variable...
Abstract Summary: An unprecedented quantity of genome sequence data is currently being generated using next-generation sequencing platforms. This has necessitated the development novel bioinformatics approaches and algorithms that not only facilitate a meaningful analysis these but also aid in efficient compression, storage, retrieval transmission huge volumes data. We present compression algorithm (DELIMINATE) can rapidly compress genomic loss-less fashion. Validation results indicate...
Metabolic adaptation of Mycobacterium tuberculosis (M. tuberculosis) to microbicidal intracellular environment host macrophages is fundamental its pathogenicity. However, an in-depth understanding metabolic adjustments through key reaction pathways and networks limited. To understand how such changes occur, we measured the cellular metabolome M. subjected four stresses using liquid chromatography-mass spectrometric multiple reactions monitoring (LC-MRM/MS). Overall, 87 metabolites were...
Abstract Background Despite advancements in genome annotation tools, challenges persist for non-classical model organisms with limited genomic resources, such as Schmidtea mediterranea . Findings To address these challenges, we developed a flexible and scalable pipeline that integrates short-read (Illumina) long-read (PacBio) sequencing technologies. The combines reference-based de novo assembly methods, effectively handling variability alternative splicing events. Functional is conducted to...
Indians, representing about one-sixth of the world population, consist several thousands endogamous groups with strong potential for excess recessive diseases. However, no database is available on Indian population comprehensive information diseases common in country. To address this issue, we present Genetic Disease Database (IGDD) release 1.0 ( http://www.igdd.iicb.res.in )—an integrated and curated repository growing number mutation data genetic afflicting populations. Currently covers 52...
Abstract Background Network visualization and analysis tools aid in better understanding of complex biological systems. Furthermore, to understand the differences behaviour system(s) under various environmental conditions (e.g. stress, infection), comparing multiple networks becomes necessary. Such comparisons between may help asserting causation identifying key components studied system(s). Although many available network comparison methods exist, which employ techniques like alignment...
Introduction Hydatid disease is an immense health problem in developing countries. The diagnosis of hydatid cyst often difficult because its protean manifestations. Our objective was to evaluate the various clinical and laboratory presentations modalities treatment from a tertiary care center. Materials methods We reviewed features patients presenting with through retrospective analysis January 2018 December 2019 hospital northeast India. Results Of 26 adult cysts who were part study, 14...
Abstract Background The marine cyanobacterium Prochlorococcus marinus , having multiple ecotypes of distinct genotypic/phenotypic traits and being the first documented example genome shrinkage in free-living organisms, offers an ideal system for studying niche-driven molecular micro-diversity closely related microbes. present study, through extensive comparative analysis various genomic/proteomic features 6 high light (HL) low (LL) adapted strains, makes attempt to identify determinants...
Background Multiple variants of the SARS-CoV-2 virus have plagued world through successive waves infection over past three years. Independent research groups across geographies shown that microbiome composition in COVID-19 positive patients (CP) differs from negative individuals (CN). However, these observations were based on limited-sized sample-sets collected primarily early days pandemic. Here, we study nasopharyngeal microbiota patients, wherein samples been witnessed India, which driven...
Sequence data repositories archive and disseminate fastq in compressed format. In spite of having relatively lower compression efficiency, continue to prefer GZIP over available specialized algorithms. Ease deployment, high processing speed portability are the reasons for this preference. This study presents FQC, a method that, addition providing significantly higher gains GZIP, incorporates features necessary universal adoption by repositories/end-users. also proposes novel archival...
Mycobacterium tuberculosis infection in humans is often associated with extended period of latency. To adapt to the hostile hypoxic environment inside a macrophage, M. cells undergo several physiological and metabolic changes. Previous studies have mostly focused on inspecting individual facets this complex process. In order gain deeper insights into process understand coordination among different regulatory/ pathways pathogen, current silico study investigates three aspects, namely, (i)...
ABSTRACT Trimethoprim-sulfamethoxazole (SXT) is commonly used to treat diverse Staphylococcus aureus infections, including those associated with cystic fibrosis (CF) pulmonary disease. Studies Escherichia coli found that SXT impairs tetrahydrofolate production, leading DNA damage, stress response induction, and accumulation of reactive oxygen species (ROS) in a process known as thymineless death (TLD). TLD survival can occur through the uptake exogenous thymidine, countering effects SXT;...
Introduction Glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency is the most common enzymopathy in humans, and its distribution has been historically described to be closely associated with that of malaria. North East India provides optimal conditions for transmission malaria bears a considerable burden Plasmodium vivax (P. vivax) Primaquine, mainstay treatment malaria, may trigger episodes acute hemolysis patients G6PD deficiency. The present study sought delineate frequency...
Abstract Background Three pathogenicity islands, viz. SPI-1 (Salmonella island 1), SPI-2 2) and T6SS (Type VI Secretion System), present in the genome of Salmonella typhimurium have been implicated virulence pathogen. While regulation (both encoding components Type III System - T3SS) are well understood, is comparatively less studied. Interestingly, inter-connections among regulatory elements these three determinants also suggested to be essential for successful infection. However, till...