A5102016738- Natural product bioactivities and synthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Natural Antidiabetic Agents Studies
- Phytochemistry and Biological Activities
- Advances in Cucurbitaceae Research
- Phytochemical compounds biological activities
- Bioactive Compounds and Antitumor Agents
- Phytochemistry and Bioactive Compounds
- Carbohydrate Chemistry and Synthesis
- Toxin Mechanisms and Immunotoxins
- Bioactive natural compounds
- Plant biochemistry and biosynthesis
- Sesquiterpenes and Asteraceae Studies
- Phytochemicals and Antioxidant Activities
- Bioactive Natural Diterpenoids Research
- Traditional and Medicinal Uses of Annonaceae
- Protein Hydrolysis and Bioactive Peptides
- Plant-derived Lignans Synthesis and Bioactivity
- Biochemical Analysis and Sensing Techniques
- Marine Sponges and Natural Products
- Phytochemical Studies and Bioactivities
- Drug-Induced Hepatotoxicity and Protection
- Biochemical effects in animals
- Synthesis and bioactivity of alkaloids
- Ginger and Zingiberaceae research
Taipei Medical University Hospital
2024-2025
National Pingtung University of Science and Technology
2015-2024
China Medical University
2008-2016
Asia University
2014
Czech Academy of Sciences, Institute of Biotechnology
2006-2011
Agricultural Biotechnology Research Center, Academia Sinica
2011
Taipei Medical University
2002-2006
National Chung Hsing University
2006
National Taiwan University
1996-2005
National Research Institute of Chinese Medicine
1997-2002
Treatment of insulin resistance is a critical strategy in the prevention and management type 2 diabetes. The crude extracts from all parts Momordica charantia L. have been reported by many studies for effective treatment diabetes related complications. However, exact ingredients responsible hypoglycemic effect underlying mechanism their actions not well characterized because lack proper assay screening system. A new cell-based, nonradioactive, nonfluorescent method was demonstrated this...
Chronic kidney disease (CKD) remains a public health problem. Certain dietary supplements can assist in the prevention of CKD progression. In this regard, resveratrol is polyphenol and has potential therapeutic role alleviating CKD. We previously utilized butyrate order to improve bioavailability via esterification generated monoester (RBM). study, hypothesis that RBM supplementation able protect against dysfunction hypertension was tested by using an adenine-induced model. For purpose,...
Four new cucurbitane-type triterpenes, cucurbita-5,23(E)-diene-3β,7β,25-triol (1), 3β-acetoxy-7β-methoxycucurbita-5,23(E)-dien-25-ol (2), cucurbita-5(10),6,23(E)-triene-3β,25-diol (5), and cucurbita-5,24-diene-3,7,23-trione (6), together with four known 3β,25-dihydroxy-7β-methoxycucurbita-5,23(E)-diene (3), 3β-hydroxy-7β,25-dimethoxycucurbita-5,23(E)-diene (4), 3β,7β,25-trihydroxycucurbita-5,23(E)-dien-19-al (7), 25-methoxy-3β,7β-dihydroxycucurbita-5,23(E)-dien-19-al (8), were isolated from...
Five new cucurbitane-type triterpenes, (23E)-25-methoxycucurbit-23-ene-3β,7β-diol (1), (23E)-cucurbita-5,23,25-triene-3β,7β-diol (2), (23E)-25-hydroxycucurbita-5,23-diene-3,7-dione (3), (23E)-cucurbita-5,23,25-triene-3,7-dione (4), and (23E)-5β,19-epoxycucurbita-6,23-diene-3β,25-diol (5), together with one known triterpene, (23E)-5β,19-epoxy-25-methoxycucurbita-6,23-dien-3β-ol (6), have been isolated from the methanol extract of stems Momordica charantia. The structures compounds were...
Despite recent advances in pharma-nutritional management, chronic kidney disease (CKD) remains an increasingly prevalent disorder. Resveratrol, a pleiotropic phytochemical, has been found to reduce the risk for several diseases. Considering low bioavailability of resveratrol, we recently synthesized resveratrol butyrate ester (RBE) via esterification with butyrate. The aim this study was examine effectiveness RBE as regards protection from hypertension and damage explore underlying...
Exposure to environmental chemicals during pregnancy and lactation is a contributing factor in gut microbiota dysbiosis linked programming of hypertension. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic dioxin, induces effects by mediating aryl hydrocarbon receptor (AHR). Resveratrol, potent antioxidant with prebiotic properties, can possess high affinity for AHR protect against TCDD-activated attack. We examined whether perinatal resveratrol therapy prevents offspring...
Four new D:C-friedooleanane-type triterpenes, 3β-O-(E)-feruloyl-D:C-friedooleana-7,9(11)-dien-29-ol (1), 3β-O-(E)-coumaroyl-D:C-friedooleana-7,9(11)-dien-29-ol (2), 3β-O-(E)-coumaroyl-D:C-friedooleana-7,9(11)-dien-29-oic acid (3), and methyl 2β,3β-dihydroxy-D:C-friedoolean-8-en-29-oate (6), together with five known triterpenes the same skeleton, 3-epikarounidiol (4), 3-oxo-D:C-friedoolena-7,9(11)-dien-29-oic (5), bryonolol (7), bryononic (8), 20-epibryonolic (9), were isolated from methanol...
This study investigated the potential effects of natural products ursolic acid (UA) and oleanolic (OA) against HBx-mediated tumorigenic activities in vitro vivo. HBx transactivated Sp-1 Smad 3/4 Huh7 FL83B hepatocytes induced cell migration HepG2. also MMP-3 secretion acted TGF-β-induced apoptosis Hep3B. UA almost completely blocked effects, while OA had a partial inhibitive effect. Utilization specific MAPK inhibitors immunoblotting demonstrated that selectively activated signaling certain...
Chin-shin oolong tea, a popular tea in Taiwan, was empirically perceived to induce hunger and accelerate gastric emptying manner similar the physiological effects of ghrelin, an endogenous acylated peptide known as hormone. Two unique flavonoid tetraglycosides previously identified were demonstrated rats food intake assay and, thus, named teaghrelin-1 teaghrelin-2. Similar GHRP-6, synthetic analogue stimulated growth hormone secretion rat primary anterior pituitary cells dose-dependent...
In fish processing, reducing the waste rate and increasing economic value of products is an important issue for global environmental protection resource sustainability. It has been discovered that cuttlefish bones can be excellent producing attractive amounts chitin chitosan. Therefore, this study optimized chitosan extraction conditions using response surface methodology (RSM) to establish application suitable industrial production impact. addition, Fourier-transform infrared spectroscopy...
Three new 5(6→7)abeoabietane diterpenes with the uncommon skeleton of fused 6–5–6 rings were isolated from bark Taiwania cryptomerioides designated as taiwaniaquinone F (8), taiwaniaquinol C (9) and D (10). Meanwhile, two known compounds, taiwaniaquinones A (1) (4), also obtained. Their structures determined principally spectral evidence.