A5014698747- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Acute Lymphoblastic Leukemia research
- Drug Transport and Resistance Mechanisms
- Autoimmune and Inflammatory Disorders Research
- Acute Myeloid Leukemia Research
- Systemic Sclerosis and Related Diseases
- Multiple Myeloma Research and Treatments
- Reproductive Health and Technologies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Reproductive Biology and Fertility
- Multiple Sclerosis Research Studies
- Bone Metabolism and Diseases
- Sperm and Testicular Function
- Chronic Myeloid Leukemia Treatments
- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Cell death mechanisms and regulation
- Galectins and Cancer Biology
- Phagocytosis and Immune Regulation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Retinoids in leukemia and cellular processes
- Sepsis Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Telomeres, Telomerase, and Senescence
Assiut University
2012-2022
Karolinska University Hospital
2020
Karolinska Institutet
2020
European Society of Cardiology
2020
Damietta University
2017
Children Cancer Hospital
2017
Assiut University Hospitals
2014-2015
Clinical Research Management
2006
We evaluated the effect of varicocelectomy on semen parameters and levels sperm DNA damage in infertile men. A total 75 men with varicocele 40 fertile (controls) were included this study. Semen analysis expressed as fragmentation index using acridine orange staining chromatin condensation test by flow cytometry assessed before 6 months after varicocelectomy. The patients also followed up for 1 year pregnancy outcome. significantly lower compared to controls (P < 0.05). Mean percentages...
Despite advances in therapy of breast and ovarian cancers, they still remain among the most imperative causes cancer death women. The first can be considered one widespread diseases females, while latter is more lethal needs prompt treatment. Thus, research field benefit from discovery new compounds that potential use management these grave illnesses. We hereby aimed to assess antitumor activity phytosterol α-spinasterol isolated Ganoderma resinaceum mushroom on human cell lines (MCF-7,...
Inflammation and coagulation occur concomitantly in sepsis. Thrombin activates platelet that leads to P-selectin translocation, which upregulate tissue factor (TF) generation. Tissue pathway inhibitor (TFPI) is an anticoagulant modulates induced by TF. The term non-overt disseminated intravascular (DIC) refers a state of affairs prevalent before the occurrence overt DIC. It was suggested initiation treatment DIC has better outcome than This study investigated role TFPI level, P-selectin,...
Programmed cell death (apoptosis) is involved in glomerular injuries leading to glomerulonephritis. Bcl-2 and Fas are proteins that promote survival death, respectively. This study tests the hypothesis lupus nephritis associated with alterations of protein expression. Thirty-six patients 10 controls (normal individuals) were included this study. positive cells examined kidney biopsies by immunohistochemistry. serum levels evaluated enzyme-linked immunosorbent assay (ELISA). In glomeruli...
Acute myeloid leukemia (AML) is a diverse disease characterized by the expansion of blasts lineage. Cytogenetic testing cornerstone for risk stratification AML patients. Geographical and environmental factors may play very important role in development several differences genetic profile be seen among different ethnicities. In our study, we evaluated cytogenetic findings adult patients South Egypt.Cytogenetic (karyotyping M-FISH) was performed 120 with AML. Twenty metaphases were analyzed...
Carvedilol is a novel β-adrenoreceptor blocker, with antioxidant properties inhibiting lipid peroxidation and preventing the depletion of endogenous antioxidants. Moreover, carvedilol was reported to enhance expression Bcl-2 gene, which has antiapoptotic effects. There are few researches testing protective effect on development diabetic cardiomyopathy nephropathy. In this study, we induced diabetes mellitus in male Wistar albino rats. We investigated carvedilol, as well vitamin E,...
We evaluated the significance of genes, defined as DRB1*04 or DRB1*01, in rheumatoid arthritis (RA) patients. focused on role genetic and serologic markers to predict disease activity destructive process joints.Sixty patients with RA were examined. Radiographic changes by (Larsen score) was measured score 28 (DAS28). The analyzed were: erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), factor (RF), anti-cyclic citrullinated peptides (anti-CCP2) HLA-DRB1 alleles typed PCR.In this...
To explore early changes in the predictors of bone turnover children with juvenile idiopathic arthritis (JIA). identify osteoprotegerin/receptor activator nuclear factor-κB ligand (OPG/RANKL) ratio serum same patients and its relation to parameters joint inflammation destruction. Seventy JIA 30 healthy individually matched for age, sex, race, county residence were included this study. Serum levels calcium (Ca), phosphorus (Ph), alkaline phosphatase (ALP), osteocalcin (OC), RANKL (OPG)...
// Reham Abdel-Wahab 1,6 , Samir Shehata 6 Manal M. Hassan 1 Lianchun Xiao 2 Ju-Seog Lee 3 Sheree Cheung Hoda H. Essa Hesham Hassabo Ahmed S. Shalaby Eman Mosad 7 Kanwal Raghav Asif Rashid 4 Robert A. Wolff Jeffrey Morris Amin 5,8 and O. Kaseb Department of Gastrointestinal Medical Oncology, The University Texas MD Anderson Cancer Center, Houston, Texas, USA Biostatistics, Systems Biology, Pathology, 5 Hematopathology, Clinical Assiut University, Egypt 8 Graduate School Biomedical Sciences,...
Abstract Background Local pelvic recurrence after radical cystectomy for muscle invasive bilharzial related squamous cell carcinoma accounts 75% of treatment failures even in organ confined tumors. Despite the proven value lymphadenectomy, up to 60% patients undergoing do not have it. These factors are favor adjuvant radiotherapy reevaluation. objectives: evaluate effect on disease free survival urinary bladder and test predictability radio-sensitivity using anti apoptotic protein Bcl-XL....
Markers of platelet activity (P-selectin), fibrinolysis (d-dimer), thrombin (prothrombin fragments 1, 2 [PF1,2] and thrombin–antithrombin III complex [TAT]), inflammation (interleukin 1β [IL-1β]) were measured in 65 patients with mitral stenosis (MS) before weeks after percutaneous valvotomy (PMV) 23 controls. All markers significantly higher than the control decreased PMV. P-selectin change correlated changes left atrial diameter (LAD), pulmonary artery systolic pressure (PASP), IL-1β....
<b><i>Background:</i></b> Therapy-related acute myeloid leukemias (t-AML), with balanced translocations affecting the 11q23 point in myeloid/lymphoid leukemia (MLL) gene, are one of most serious complications treatments topoisomerase II inhibitors. However, only a few reports t-AML exist. We aimed to study if these cumulative-dose-dependent, their frequency therapy-related myelodysplastic syndrome and relationship between presence, type therapy response criteria....
We have analyzed t(12;21)(p13:q22) in an attempt to evaluate the frequency and prognostic significance of TEL-AML1 fusion gene patients with childhood CD 10 positive B-ALL by fluorescence situ hybridization (FISH). Also, we monitored value this as a minimal residual disease (MRD).All bone marrow samples eighty diagnosed South Egypt Cancer Institute were evaluated (FISH) for t(12;21) newly cases after morphological complete remission (MRD). determined represented course survival.TEL-AML1 was...
This study aimed to assess the possible correlation between mammalian target of rapamycin (mTOR) gene expression and sperm DNA damage among infertile patients with without varicocele. The included sixty males fifty fertile as controls. group was subdivided into following subgroups: thirty varicocele All subjects underwent medical history collection, clinical examination, semen analysis, integrity assessment, mTOR assessment scrotal colour Doppler ultrasound. mean in (23.52 ± 14.65)...
To analyze the relationship between miRNA-146a rs2910164 and rheumatoid arthritis (RA) susceptibility clarifying its association with disease activity extra-articular involvement. The study enrolled 50 RA patients 40 controls. DNA extraction from whole blood was done. Genotyping performed by real-time polymerase chain reaction. selected single nucleotide polymorphism in gene. on genomic samples allelic discrimination assay. Disease score (DAS28) health assessment questionnaire-disability...
Abstract Background Telomere stability is one of the hallmarks cancer that promotes cellular longevity, accumulation genetic alterations, and tumorigenesis. The loss death domain-associated protein (DAXX) α-thalassemia/mental retardation X-linked (ATRX) plays a role in telomere lengthening stability. This study aims to evaluate prognostic significance length (TL) its association with DAXX ATRX proteins breast (BC). Our used FISH technique detect peptide nucleic acid (PNA) peripheral blood...
Summary The hepatitis C virus ( HCV ) core protein is able to accumulate genetic p53 mutations and may be considered co‐oncogenic. This study investigates 1p36.3 telomere deletion in B‐non‐Hodgkin's lymphoma NHL patients with chronic infection using fluorescence situ hybridization FISH relation survival assess Ki‐67 antigen expression. A group a control of 100 B‐ (50 positive 50 negative) 60 bone marrow biopsies were subjected for the detection 1P36.3 immunohistochemical staining antigens....
Systemic sclerosis (SSc) is an autoimmune connective tissue disease with vascular, fibrotic and immune changes of skin some internal organs. Anti-heterogeneous nuclear ribonucleoproteins (anti-hnRNP) were found in SSc patients. To assess anti-hnRNP A1 A2 autoantibodies limited patients to find their relation clinical hand radiographic characteristics. 26 16 matched control studied. Skin thickness was scored according the modified Rodnan score method (mRss) radiologic examination by plain...
Background: CD44 is an epithelial-mesenchymal transition (EMT) surface receptor that regulates the interactivity between cells and extracellular matrix, thereby promoting cell migration. The epidermal growth factor (EGFR) family a trans-membrane kinase-related protein. It adhesion proteins, which may promote proliferation invasiveness. Mesenchymal epithelial (MET) another EMT stimulates proliferation, invasion, survival, angiogenesis. This study aimed to evaluate prognostic impact of CD44,...