There is growing evidence for a gut-brain connection associated with autism spectrum disorders (ASDs). This suggests potential benefit from introduced digestive enzymes children ASD.We performed double-blind, randomized clinical trial on 101 ASD (82 boys and 19 girls) aged 3 to 9 years. patients were diagnosed according the Diagnostic Statistical Manual of Mental Disorders 4th edition, text revision (DSM-IV-TR) diagnostic criteria. Structured interviews at least one hour each both parents...

Abstract Background This study aimed to assess neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte (MLR) as inflammatory markers in diabetic pediatrics with without ketoacidosis (DKA) evaluate their DKA diagnostic ability the absence of infection. Methods cross-sectional observational encompassed a total 70 children who were either admitted or sought outpatient consultations at Assiut University Pediatric Hospital (Assiut, Egypt) between August 2022 May 2023. The pediatric...

Type 1 diabetes mellitus is associated with cognitive changes, but the extent of cognition decline depends on age at onset, duration diabetes, and occurrence attacks hypoglycemia or ketoacidosis. This study was designed to assess function in a group children type mellitus. A total 40 diabetic were recruited from pediatric department Assiut University Hospital, Egypt. Forty healthy matched for age, sex, socioeconomic status chosen as controls comparison. Cognition assessed using...

Inflammation and coagulation occur concomitantly in sepsis. Thrombin activates platelet that leads to P-selectin translocation, which upregulate tissue factor (TF) generation. Tissue pathway inhibitor (TFPI) is an anticoagulant modulates induced by TF. The term non-overt disseminated intravascular (DIC) refers a state of affairs prevalent before the occurrence overt DIC. It was suggested initiation treatment DIC has better outcome than This study investigated role TFPI level, P-selectin,...

To study the frequency of vitamin D deficiency in patients with hepatitis C virus (HCV) infection and to evaluate role supplementation improving antiviral therapy.Sixty-six children aged from 7-14 years (mean ± SD, 11.17±2.293) diagnosed HCV were matched 28 healthy controls. Serum levels 25 (OH) D3, calcium, phosphorus, alkaline phosphatase plasma level parathormone measured. Quantitative PCR for was performed Bone density determined by dual energy X-ray absorptiometry. All cases received...

The study aimed to define the frequencies of type 1 diabetes-associated gene polymorphisms and their associations with various autoantibodies in Egyptian children.One hundred one children diabetes 160 healthy controls from same region were studied for HLA-DQB1, HLA-DQA1, HLA-DRB1 (DR4 subtypes) alleles; INS protein tyrosine phosphatase, non-receptor 22 (rs689 rs2476601); autoantibodies.Most (77.2%) positive HLA-(DR3)-DQA1*05-DQB1*02 (DR3-DQ2) haplotype compared 26.2% (OR = 9.5; p < 0.001)....

Objective: Congenital and acquired prothrombotic disorders have been highlighted in a recent series of cerebrovascular stroke (CVS), with controversial role pathogenesis. The aim is to study some risk factors [activated protein C (APC) resistance, von Willebrand factor (vWF), anticardiolpin (ACL) antibodies plasma homocysteine] children ischemic stroke, evaluate the aspirin low molecular weight heparin (LMWH) its management relation outcome. Methods: A total 37 cases aged from 1 month 15...

Providing oral care hygiene for children at intensive unit and protecting mucosa are important in the promotion of healthy nutrition, comfort, improving patients' quality life, as well preventing mucositis.Aim: to evaluate role chlorhexidine mucositis among ventilated children.Subjects Method: design: Quasi-experimental research design was used this study Sample: The included 60 (>6 years age) admitted PICU needed mechanical ventilation.They were divided into two groups: group one (30...

Many studies have reported cognitive and behavioral abnormalities with recurrent seizures in adults. Similar evidence from the pediatric population is scarce controversial. We aimed to investigate effect of on developing brain. Included were 42 children epilepsy (mean age 14.1±1.72 yr) 30 healthy for comparison. Patients had untreated (generalized or focal). Negative attitudes misconceptions about are common countries, often resulting neglect medical services treatment. Epilepsy greatly...

<title>Abstract</title> <bold>Purpose:</bold> To evaluate left venticular, vascular endothelial function and its association with adrenomedullin (AM) levels in children classic CAH. <bold>Methods:</bold> 42 CAH (mean age of 13.5±2.4 years) were compared to healthy controls. Measurement 17-hydroxy-progesterone, total testosterone, AM carried out. LV functions cardiac dimensions measured traditional echocardiography. Brachial artery flow-mediated dilation (FMD%) carotid intima-media thickness...

Reduction in sensory inputs is considered one of the most common complications following intensive care unit (ICU) admission. Changes physiologic parameters are brought about by auditory stimulation, which hastens recovery. So, this study aimed to examine effect mother voice on physiological and level consciousness patients pediatric unit. Research design setting: A quiz experimental was carried out from beginning March 2022 till end October ICU at Assiut University Children's Hospital,...

Background Scorpion stings are common emergency events in Upper Egypt, with significant morbidity and mortality. We aimed to investigate the hematological parameter their relation severity of envenomation children presenting scorpion stings. Methods The current study is an observational hospital-based case-control that was carried out at Emergency Intensive Care Units, from January 2022 December 2022. parameters were compared between these cases those controls. Results included 42 studied...

In the case of SLE, Treg deficiencies have been described in mouse models SLE. However, there are somehow conflicting data literature on whether cells human SLE numerically and/or functionally impaired. We aimed to quantify CD4+CD25+Foxp3+ T children with and correlate these findings their disease activity scores drug therapy. enrolled 37 pediatric patients 20 healthy children. The was assessed by measuring serum levels anti-dsDNA antibody using SLEDAI. CD4+CD25+, CD4+CD25^bright...

Hirschsprung's disease (HD) presents itself by delayed passage of meconium, neonatal bowel obstruction and/or chronic constipation. In 80% cases the is diagnosed in first year life. Difficulties or misdiagnosing HD are infrequently met. The aim this case series to highlight pitfalls diagnosis and treatment HD. A 4 6 months old ♂ were as rectal perforation period colostomy was performed. At age respectively they developed fecal fistula after closure. Revision stoma done biopsy proved that...