A5041196618- Sphingolipid Metabolism and Signaling
- Complement system in diseases
- Cancer Cells and Metastasis
- Hematopoietic Stem Cell Transplantation
- Neurogenesis and neuroplasticity mechanisms
- Pancreatic and Hepatic Oncology Research
- Tryptophan and brain disorders
- Pancreatic function and diabetes
- Pregnancy-related medical research
- Organ Transplantation Techniques and Outcomes
- Preterm Birth and Chorioamnionitis
- Renal Transplantation Outcomes and Treatments
- Circadian rhythm and melatonin
- Erythrocyte Function and Pathophysiology
- Lymphatic System and Diseases
- Fibroblast Growth Factor Research
- Parathyroid Disorders and Treatments
- Neuroblastoma Research and Treatments
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Apelin-related biomedical research
- Pancreatitis Pathology and Treatment
- Exercise and Physiological Responses
- Liver Disease and Transplantation
- Spaceflight effects on biology
Pomeranian Medical University
2014-2025
University of Szczecin
2023-2024
University of Louisville
2014
James Graham Brown Foundation
2014
Malignant tumors are the second most common cause of death worldwide. More attention is being paid to link between body’s impaired oxidoreductive balance and cancer incidence. Much polyphenols derived from plants, as one their properties an antioxidant character: ability eliminate reactive oxygen nitrogen species, chelate specific metal ions, modulate signaling pathways affecting inflammation, raise level activity enzymes while lowering those with oxidative effects. The following three...
The role of blood proteinases in the mobilization hematopoietic stem/progenitor cells (HSPCs) is still not well understood. As previously reported, activation complement cascade (ComC) and cleavage C5 by convertase are enabling events release C5a that plays a crucial egress HSPCs from bone marrow (BM) into peripheral (PB) explains why C5-deficient mice poor mobilizers. Here we provide evidence during granulocyte colony-stimulating factor- AMD3100-induced mobilization, only ComC but also two...
In this paper we tested a group of 66 healthy volunteers in terms the influence circadian rhythm on selected parameters coagulation system and fibrinolytic system. Blood was collected at 6-hour intervals, 8 am, 2 pm, pm am. Circadian variability observed as well We increased platelet aggregation, APTT prolongation, along with levels factors (fibrinogen, PAI-1) PAP TAT complexes that fibrinolysis systems, blood samples morning (8 am). also demonstrated number circulating platelets (PLT), peak...
Abstract Various experimental studies indicate potential involvement of bone marrow ( BM )‐derived stem cells SC s) in malignancy development and progression. In this study, we comprehensively analysed systemic trafficking various populations BM‐derived SCs BMSC s), i.e ., mesenchymal, haematopoietic, endothelial stem/progenitor MSC s, HSC EPC s respectively), recently discovered population very small embryonic/epiblast‐like VSEL pancreatic cancer patients. Circulating CD 133 + /Lin − / 45...
Background/Aims Recent experimental studies have suggested that various cytokines may be important players in the development and progression of pancreatic cancer. However, these findings not yet been verified a clinical setting. Methods In this study, we examined levels broad panel cytokines, including interleukin (IL)-1, IL-6, IL-8, IL-10, IL-12, IL-17, IL-23, as well tumor necrosis factor alpha (TNFα) granulocyte-colony stimulating (G-CSF) patients with adenocarcinoma (n = 43), other...
Lysophosphatidic acid (LPA) is a bioactive lipid with wide biological activity. Previous studies have shown its potential usefulness as diagnostic marker for ovarian cancer. The aim of the study was to investigate which factors may influence plasma LPA concentrations in healthy subjects and propose reference values.The group consisted 100 subjects. From all them blood samples were taken at 7 a.m. (fasting state). 40 volunteers additional 2 p.m., 8 p.m. next morning. Concentrations measured...
The circadian system synchronizes daily with the day–night cycle of our environment. Disruption this rhythm impacts emergence and development many diseases caused, for example, by overproduction free radicals, leading to oxidative damage cellular components. goal study was determine activity superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), transferase (GST), reductase (R-GSSG), concentration (GSH) in rhythm. group comprised 66 healthy volunteers (20–50 years; 33...
The multitude of processes in which the liver participates makes it vulnerable to many serious diseases, can lead chronic organ failure. Modern medicine bases treatment end-stage failure on transplantation. To ensure proper functioning transplanted liver, a balance cellular and immunological appropriate concentrations different factors are necessary, including, among others, fibroblast growth (FGFs). Over last several years, studies have focused some FGF factors, i.e., FGF19 FGF21. These two...
The complement cascade seems to be an important mediator modulating renal ischemia/reperfusion injury. This study analyzed whether significant changes occur in the levels of a terminal panel molecules (C3a, C5a, and C5b-9/membrane attack complex) during early phase human kidney allograft reperfusion evaluated potential association these with clinical post-transplant graft function transplant recipients.Seventy-five recipients undergoing transplantation between 2004 2006 were enrolled divided...
The aim of our research was to examine whether winter-swimming for five consecutive months results in adaptational changes improving tolerance stress induced by exposure cryogenic temperatures during whole-body cryostimulation (WBC). involved 15 healthy men, with normal bodyweight, who had never been subjected either WBC or cold water immersion. During the experiment, participants were twice (3 min/- 130°C), namely before season and after season. Blood taken seven times: In morning each...
The number of hematopoietic stem/progenitor cells (HSPCs) circulating in peripheral blood (PB) is regulated by a circadian rhythm, and more HSPCs circulate PB the morning hours than at night. Different mechanisms have been proposed that might regulate this process, including changes tonus β-adrenergic innervation bone marrow (BM) tissue. Our group reported mice correlates with diurnal activation complement cascade (ComC) deficient C5 component ComC (C5-KO mice) do not show PB. We also...
Introduction: The immune system is undoubtedly involved in the pathogenesis of various psychiatric disorders, such as schizophrenia, bipolar disorder or depression. Although its role not fully understood, it appears that this area research can help to understand etiology mental illness. One components human complement system, which forms a part innate response. Physiologically, except for essential protective role, vital element regeneration processes, including neurogenesis. To date, few...
It has been suggested that action of complement cascade [CC]-derived anaphylatoxins/molecules may represent a missing link between obesity and metabolic disorders. However, to date, the direct biochemical/immunomodulatory composition human AT environment remains poorly understood. In this study, we examined plasma (subcutaneous visceral/omental) levels selected CC-derived anaphylatoxins/molecules, adipsin as well verified their associations with immune stem cells chemoattractant -...
Abstract Abnormal interactions between cytokines may be an overlooked mechanism linking the development of different types gastric neoplasms. In this study a comprehensive analysis systemic levels interleukins (IL-1,IL-6, IL-8,IL-10 and IL-12) was performed in 75 patients with neoplasms (cancer, gastrointestinal stromal tumors, neuroendocrine neoplasms, lymphomas) 40 healthy volunteers. Patients cancer (GC) have significantly higher IL-6 lower IL-8 IL-10 concentrations, comparison to...
Recently, there has been a growing interest in the importance of stem cells (SCs) development/progression gastric neoplasms. In this study, we performed comprehensive analysis different populations bone-marrow-derived (BMSCs) patients with various types malignancies, including cancer, gastrointestinal stromal tumors (GISTs), neuroendocrine neoplasms (NENs), and lymphomas. We found significantly lower numbers circulating Lin-/CD45 +/ CD133 + hematopoietic stem/progenitor (HSPCs), intensified...
Introduction: Insulin resistance is a frequent abnormality in chronic kidney disease (CKD) appearing early stages. Factors known to promote insulin CKD patients include disorders of ion and acid–base equilibrium circulating uremia toxins. Recent research has focused on the central nervous system as source brain-derived neurotrophic factor (BDNF). The aim our work was study plasma BDNF concentrations stage 3 4 relationship with distribution adipose tissue. Method: Plasma were measured group...
In this paper we examined whether stem cells and factors responsible for their movement may serve as new biological markers of anxiety disorders. The study was carried out on a group 30 patients diagnosed with panic disorder (examined before after treatment), compared to healthy individuals forming the control group. We number circulating HSCs (hematopoetic cells) (Lin−/CD45 +/CD34 +) +/AC133 +), VSELs (very small embryonic-like (Lin−/CD45−/CD34 (Lin−/CD45−/AC133 well concentration...
<b><i>Background:</i></b> Patients suffering from chronic kidney disease (CKD) are exposed to increased oxidative stress and disturbances manifesting in the enzymatic non-enzymatic antioxidative defence system. The object of research was assess differences between conservative treatment, peritoneal dialysis haemodialysis moderating cellular agents. <b><i>Methods:</i></b> group examined comprised 145 patients. activities superoxide dismutase,...
The liver has a huge impact on the functioning of our body and preservation homeostasis. It is exposed to many serious diseases, which may lead chronic failure this organ, becoming global health problem today. Currently, final form treatment in patients with end-stage (acute chronic) organ transplantation. proper function transplanted organs depends cellular processes immune individual factors. An enormous role process acceptance or rejection attributed to, among others, activation...
Platelets are actively involved in tissue injury site regeneration by producing a wide spectrum of platelet-derived growth factors such as PDGF (platelet-derived factor), IGF-1 (insulin-like TGF-β1 (transforming factor β), FGF (fibroblast etc. A rotating magnetic field (RMF) can regulate biological functions, including reduction or induction regarding inflammatory processes, cell differentiation, and gene expression, to determine the effect an RMF on regenerative potential platelets. The...