A5068670495- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Lung Cancer Diagnosis and Treatment
- Mycotoxins in Agriculture and Food
- Optical Coherence Tomography Applications
- Photoacoustic and Ultrasonic Imaging
- Cancer, Hypoxia, and Metabolism
- Natural product bioactivities and synthesis
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Parathyroid Disorders and Treatments
- Radiopharmaceutical Chemistry and Applications
- Advanced Radiotherapy Techniques
- Monoclonal and Polyclonal Antibodies Research
- Pancreatic and Hepatic Oncology Research
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer, Lipids, and Metabolism
- Asthma and respiratory diseases
- Skin Protection and Aging
- Plant biochemistry and biosynthesis
- Toxin Mechanisms and Immunotoxins
- Neuroendocrine Tumor Research Advances
- Cervical Cancer and HPV Research
- Angiogenesis and VEGF in Cancer
- Phytochemistry and Biological Activities
Tokyo Denki University
2024
Tokyo Medical University
2011-2022
Kwansei Gakuin University
2021
Tokyo Medical University Hospital
2006-2020
Occupational Cancer Research Centre
2015
British Association for Immediate Care Scotland
2015
BASilar artery International Cooperation Study
2015
BC Cancer Agency
2011-2014
International University of Health and Welfare
2006
Assiut University
2000
Most centrally located early lung cancers (CLELC) <1.0 cm in diameter do not invade beyond the bronchial cartilage, and photodynamic therapy (PDT) with Photofrin is currently recommended as a treatment option for such lesions. NPe6 second-generation photosensitizer, because it has longer absorption band (664 nm) than (630 nm), we hypothesized that NPe6-PDT would exert strong antitumor effect against cancer lesions >1.0 diameter, which are assumed to involve extracartilaginous invasion be...
Abstract Background and Objectives We have been engaged in basic clinical research on photodynamic therapy (PDT) diagnosis (PDD) for more than 25 years. Study Design/Materials Methods PDT 264 centrally located early‐stage lung cancer lesions yielded an initial complete response (CR) rate of 84.8%. is now becoming a standard option stage 0 (TisN0M0) I (T1N0M0) cancer. It attractive elderly patients poor physical condition. Results Recent results interstitial peripheral‐type cancers suggest...
ATX-s10 is a novel and second-generation photosensitizer for photodynamic therapy (PDT). In order to conduct clinical trials of ATX-s10-PDT and/or extend its applications, it very important elucidate the mechanisms action ATX-s10-PDT. We examined apoptic response against using Bcl-2 or mutant overexpressing cells. Using fluorescent microscopy, localized not only mitochondria but also lysosomes possibly other intracellular organelles, plasma membrane nucleus. These results suggest that can...
Next‐generation sequencing ( NGS ) and digital PCR technologies allow analysis of the mutational profile circulating cell‐free DNA (cf in individuals with advanced lung cancer. We have now evaluated feasibility cf for mutation detection patients non‐small cell cancer at earlier stages. A total 150 matched tumor serum samples were collected from stages IA – IIIA . Amplicon extracted tissue detected frequent mutations EGFR (37% patients), TP 53 (39%), KRAS (10%), consistent previous findings....
Examining and quantifying changes in airway morphology is critical for studying longitudinal pathogenesis interventions diseases such as chronic obstructive pulmonary disease asthma. Here we present fiber-optic optical coherence tomography (OCT) a nondestructive technique to precisely accurately measure the 2-dimensional cross-sectional areas of wall substructure divided into mucosa (WAmuc), submucosa (WAsub), cartilage (WAcart), total area (WAt). Porcine lung specimens were dissected from...
From roots of Anemone rivularis, used in Chinese folk medicine, four new oleanane-saponins named huzhangosides A, B, C and D were isolated along with two known saponins their structures elucidated by means 13C-NMR, MS modified sequence analysis GC-MS.
For the first time, use of fiber-optic color Doppler optical coherence tomography (CDOCT) to map in vivo three-dimensional (3-D) vascular network airway segments human lungs is demonstrated. Visualizing 3-D may provide new opportunities for detecting and monitoring lung diseases such as asthma, chronic obstructive pulmonary disease, cancer. Our CDOCT instrument employs a rotary probe that provides simultaneous two-dimensional (2-D) real-time structural (OCT) imaging at frame rates up 12.5...
Optical coherence tomography (OCT) is a promising imaging technique to evaluate small airway remodeling. However, the short-term insertion-reinsertion reproducibility of OCT for evaluating same bronchial pathway has yet be established. We evaluated 74 data sets from 38 current or former smokers twice within single session. Although overall wall thickness (WT) measurement coefficient variation (CV) was moderate at 12%, much variability between repeat attributed observer; CV repeated...
NPe6 is a novel second-generation photosensitizer used for photodynamic therapy (PDT). PDT using and diode laser (664 nm) induces cell death, inflammatory reactions, immunological responses damage to the microvasculature. In this study, we evaluated influence of enhanced angiogenesis on anti-tumor effect NPe6-PDT cytokine-overexpressing Lewis lung carcinoma (LLC), LLC-IL-2 cells both in vitro vivo. We showed by DNA microarray analysis that IL-2 GADD-45alpha (growth arrest 45 alpha) mRNA...
PDT induces apoptosis, inflammatory reactions, immune and damage to the microvasculature around tumors. The mechanisms responsible for anticancer effects of Photofrin-PDT NPe6-PDT differ somewhat. To select a photosensitizer lung cancer treatment improve efficacy PDT, action using Photofrin or NPe6 must be elucidated phenomena validated by analyzing molecular determinants from clinical samples.We examined role immunological reactions in anti-tumor cytokine-overexpressing cells investigated...
Culture filtrates of Fusarium species were subjected without clean-up procedures to an indirect competitive enzyme-linked immunosorbent assay with anti-T-2 toxin monoclonal antibody. sporotrichioides, F. poae, tricinctum, and culmorum strains positive for T-2 toxin, a minimum detection limit 5 pg per (100 pg/ml culture filtrate), the data correlated well gas-liquid chromatographic data.
A male infant with an atypical form of Menkes kinky hair disease showed mitochondrial NADH-CoQ reductase (complex I) deficiency in a femoris muscle biopsy. His clinical features consisted hypotonicity the upper limbs, hyperreflexia lower extremities, abnormal and fine myoclonic movement hands.