A5035188407- Curcumin's Biomedical Applications
- Alzheimer's disease research and treatments
- Advanced biosensing and bioanalysis techniques
- Iron Metabolism and Disorders
- Biochemical effects in animals
- RNA Interference and Gene Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticle-Based Drug Delivery
University of Milano-Bicocca
2022-2024
Istituti Clinici Scientifici Maugeri
2020
Abstract The identification of a highly sensitive method to check the delivery administered nanodrugs into tumor cells is crucial step preclinical studies aimed develop new nanoformulated cures, since it allows real therapeutic potential these devices be forecast. In present work, ability an H‐ferritin (HFn) nanocage, already investigated as powerful tool for cancer therapy thanks its actively interact with transferrin receptor 1, act efficient probe monitoring nanodrug tumors demonstrated....
The global demographic shift towards an aging population is generating a rise in neurodegenerative conditions, with Alzheimer's disease (AD) as the most prominent problem. In this landscape, use of natural supplements has garnered attention for their potential dementia prevention. Curcumin (Cur), derived from Curcuma longa, demonstrated promising pharmacological effects against AD by reducing levels inflammatory mediators. However, its clinical efficacy hindered poor solubility and...
Bisdemethoxycurcumin (BDC) might be an inflammation inhibitor in Alzheimer's Disease (AD). However, BDC is almost insoluble water, poorly absorbed by the organism, and degrades rapidly. We thus developed a new nanoformulation of based on H-Ferritin nanocages (BDC-HFn).We tested BDC-HFn solubility, stability, ability to cross blood-brain barrier (BBB) model. effect AD control (CTR) PBMCs evaluate transcriptomic profile RNA-seq.We with diameter 12 nm improve solubility stability. The...