A5012935309- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Infectious Diseases and Tuberculosis
- Bacterial biofilms and quorum sensing
- Enterobacteriaceae and Cronobacter Research
- Enzyme-mediated dye degradation
- Infectious Diseases and Mycology
- Bacterial Identification and Susceptibility Testing
- Pharmaceutical and Antibiotic Environmental Impacts
- Advanced Biosensing Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Diagnosis and treatment of tuberculosis
- Pneumonia and Respiratory Infections
- Infections and bacterial resistance
- Enzyme Catalysis and Immobilization
- Eicosanoids and Hypertension Pharmacology
- Vibrio bacteria research studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Antibiotic Use and Resistance
- vaccines and immunoinformatics approaches
- Bacillus and Francisella bacterial research
- Pneumocystis jirovecii pneumonia detection and treatment
- Microplastics and Plastic Pollution
- Immunodeficiency and Autoimmune Disorders
Jawaharlal Institute of Post Graduate Medical Education and Research
2015-2024
ESI - Post Graduate Institute of Medical Science and Research
2023
Periyar University
2013-2014
Madurai Kamaraj University
2011
Detection of carbapenemases among Gram-negative bacteria (GNB) is important for both clinicians and infection control practitioners. The Clinical Laboratory Standards Institute recommends Carba NP (CNP) as confirmatory test carbapenemase production. reagents required CNP are costly hence the cannot be performed on a routine basis. present study evaluates modifications rapid detection GNB.The GNB were screened production using CNP, CarbAcineto (CANP), modified (mCNP) test. A multiplex...
Non tuberculous mycobacteria (NTM) is an emerging opportunistic pathogen increasing globally and indistinguishable from tuberculosis (TB), which remains a challenge particularly in developing countries. This study aimed to identify the prevalence diversity of NTM among both pulmonary TB (PTB) extrpulmonary (EPTB) clinical isolates south India. A total 7633 specimens suspects (PTB, n = 4327 EPTB, 3306) were collected during period (July 2018–March 2020) tertiary care hospital. The subjected...
Tuberculosis (TB) remains a major global threat and diagnosis of active TB ((ATB) both extra-pulmonary (EPTB), pulmonary (PTB)) latent (LTBI) infection challenging, particularly in high-burden countries which still rely heavily on conventional methods. Although molecular diagnostic methods are available, e.g., Cepheid GeneXpert, they not universally available all high burden countries. There is intense focus immune biomarkers for use diagnosis, could provide alternative low-cost, rapid...
Background: Studying DNA methylation changes in disease condition provides the basis of pathogenesis or host immune response to infection. Evidences suggest that pathogen-mediated influences expression pattern genes contributing avert response. Hence, we attempted study association between tubercle bacilli-mediated global children with tuberculosis (TB) and healthy controls. Methods: Forty-three diagnosed TB 33 were enrolled this study. ELISA-based quantification was performed measure...
Tuberculosis (TB) remains a significant global health crisis and the number one cause of death for an infectious disease. The consequences in high-burden countries are significant. Barriers to TB control eradication part caused by difficulties diagnosis. Improvements diagnosis required organisations like World Health Organisation (WHO) meet their ambitious target reducing incidence 50% year 2025, which has become hard reach due COVID-19 pandemic. Development new tests key priorities WHO, as...
Abstract The present study was undertaken to develop a cost effective stabilized horseradish peroxidase (HRP) for removal of phenol and decolorization malachite green from synthetic wastewater. As revealed by enzyme stabilization assays, guar gum galactose improved the stability HRP successfully in solution state as compared other additives such pectin, carrageenan, or starch, respectively. In order enhance HRP, combination were effectively optimized together along with pH constructing an...
Tuberculosis remains a global public health challenge, with substantial number of undiagnosed cases contributing to ongoing transmission and increasing disease burden. A cost-effective triage test for individuals displaying tuberculosis symptoms or at risk could offer an affordable solution. In this regard, non-sputum-based tests that have minimum 90% sensitivity 70% specificity been prioritised by WHO rule out identify the require further testing. Such might reduce treatment delays, overall...
Objectives: This study is aimed to investigate the prevalence of genes encoding extended-spectrum β-lactamases (ESBLs) and carbapenemases production among Enterobacteriaceae isolated from North East India. Materials Methods: A total 210 non-duplicate multi-drug resistant (MDRE) strains were included in this investigation. The isolates third-generation cephalosporins, aminoglycosides, fluoroquinolones. First, subjected phenotypic assays determine ESBLs production; then, multiplex polymerase...
Tuberculous meningitis (TBM) is the most severe form of Mycobacterium tuberculosis (Mtb) infection in humans and a public health concern worldwide. We evaluated performance GeneXpert MTB/RIF (GeneXpert) for diagnosis TBM. In addition, genetic diversity drug susceptibility profiling Mtb strains isolated from TBM patients were also investigated. A total 293 suspected cerebrospinal fluid (CSF) samples collected subjected to Mycobacterial Growth Indicator Tube (MGIT 960) culture, respectively....
The present study was undertaken to screen for carbapenem resistance and the ability of efflux pump inhibitors inhibit this in enterobacteriaceae strains isolated from clinical specimens patients attending Jawaharlal Institute Post Graduate Medical Education Research (JIPMER) hospital water samples around Puducherry. A total 425 resistant isolates were studied by both phenotypic genotypic methods. Two hundred forty eight (248) positive metallo beta lactamase double disk synergy test (DDST)...
We aimed this study to standardize real time - polymerase chain reaction (RT-PCR) for the detection of Mycobacterium tuberculosis (Mtb) in cerebrospinal fluid (CSF) samples and compare its diagnostic performance with GeneXpert (Xpert), Mycobacteria Growth Indicator Tube (MGIT) Multiplex PCR (MPCR) tuberculous meningitis (TBM). A total 217 CSF were obtained from patients suspected TBM during period between January 2019 December 2021. The optimal cycle threshold (CT) RT-PCR was determined by...
Tuberculous meningitis (TBM) is caused by the dissemination of Mycobacterium tuberculosis (MTB) from primary site infection to central nervous system. However, bacterial factors associated with pathogenesis TBM remain unclear. This study employed transcriptomic and proteomic methods comprehensively analyze changes in genes proteins their pathways MTB strains isolated cerebrospinal fluid (CSF) sputum pulmonary TB (PTB) cases. Five were subjected OMICs (transcriptomic proteomic) analysis....
Antibiotics like colistin can save patients infected with carbapenem-resistant Pseudomonas aeruginosa. However, succumb to such infections even if they undergo therapy. This prompted us investigate the probable antimicrobial resistance mechanisms and virulence determinants involved in colistin- P. aeruginosa (CCRPA). Of 448 clinical strains, 19 isolates were resistant both carbapenem. Carbapenemases efflux pump encoding genes assessed by multiplex PCR qPCR, respectively. blaVIM was detected...
The occurrence of carbapenem resistance among Enterobacteriaceae has reached critical levels worldwide. present study was carried out to screen for isolates from blood, surgical wound and tracheal samples in different wards intensive care units between the period 2010 through 2012 a teaching hospital attached JIPMER, south India. A total number 425 meropenem-resistant belonging were included. Genes encoding β-lactamases (blaNDM-1 blaOXA-48) influx β-lactams major porin OmpK36 characterized....
Introduction:This study aimed to evaluate the performance of Mycobacterium Growth Indicator Tube 960 (MGIT960) and Lowenstein-Jensen (LJ) medium for recovery mycobacteria in pulmonary tuberculosis (PTB) drug susceptibility testing (DST). Materials Methods:A total 2411 specimens were collected from TB suspected patients during period (July 2018 March 2020).Specimens inoculated into both MGIT960 LJ followed by Ziehl-Neelsen (ZN) Auramine Phenol (AP) staining.DST was performed MGIT...