A5098994190- Epigenetics and DNA Methylation
- Microtubule and mitosis dynamics
- Connexins and lens biology
- Congenital heart defects research
- Immune Cell Function and Interaction
- Developmental Biology and Gene Regulation
- Genetics and Neurodevelopmental Disorders
- Cancer-related molecular mechanisms research
Institute for Stem Cell Biology and Regenerative Medicine
2024
Abstract Euchromatic histone methyltransferases (EHMT1/2) play a key role in adipogenesis by regulating gene expression. While the downstream functions of EHMTs adipogenic differentiation have been studied, their regulation and precise individual contributions remain elusive. We discovered existence regulatory mechanism, wherein EHMT1 governs interdependent expression itself master regulator PPARƴ during early phase adipogenesis. In later stages, EHMT2 levels decline along with reduction...
ABSTRACT Early dorsal telencephalon development is coordinated by an interplay of transcription factors that exhibit a graded expression pattern in neural progenitors. How they function together to orchestrate cortical remains largely unknown. The Emx2 and Dmrta2 genes encode TFs are expressed similar caudomedial high / rostrolateral low gradient the ventricular zone developing with, medial pallium, but not choroid plexus. Their constitutive loss has been shown impart abnormalities, their...
Dmrta2 (also designated Dmrt5) is a transcriptional regulator expressed in cortical progenitors caudomedial-high/rostrolateral-low gradient with important roles at different steps of development. has been suggested to act cortex development mainly by differential suppression Pax6 and other homeobox transcription factors such as the ventral telencephalic Gsx2, which remains be fully demonstrated. Here we have addressed epistatic relation between comparing phenotypes mutant embryos or...