A5020569831- Estrogen and related hormone effects
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Hormonal and reproductive studies
- Lipid metabolism and biosynthesis
- SARS-CoV-2 detection and testing
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Food Allergy and Anaphylaxis Research
- Sleep and Wakefulness Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gut microbiota and health
- Mast cells and histamine
- Cassava research and cyanide
- Head and Neck Cancer Studies
- African Botany and Ecology Studies
- Vitamin D Research Studies
- Prostate Cancer Diagnosis and Treatment
- Global Maternal and Child Health
- Glutathione Transferases and Polymorphisms
- Bone health and osteoporosis research
- Nuclear Receptors and Signaling
- Agriculture and Rural Development Research
- Diet, Metabolism, and Disease
- Redox biology and oxidative stress
University of Lagos
2016-2023
University College Hospital, Ibadan
2023
Laboratory of Molecular Genetics
2022-2023
University of Ibadan
2020-2023
Achievers University
2016-2018
Creative Commons
2016
Rivers State University
2014
Kolanut contains caffeine and it is widely consumed in various social contexts Nigeria other Sub-Saharan African countries. While some studies have suggested that kolanut by pregnant women, there a dearth of information on the prevalence, consumption pattern reasons for among this group. This study investigated use women Ibadan, Oyo State, Nigeria. A cross-sectional involving 478 consenting all trimesters pregnancy was conducted. Semi-structured questionnaires were used to collect data....
Background : Early diagnosis, detection and treatment have been one of the main goals reducing mortality from benign prostatic hyperplasia (BPH) prostate cancer (PCA). The most common used screening diagnostic tool for this condition is serum specific antigen (PSA) level. Since PSA synthesized by other tissues besides normal tumor cells, specificity as a biomarker BPH PCA has called into question may be improved. Therefore, markers disease are being sought. gamma glutamyl transferase GGT...
Background and Purpose: Hypertension is a major medical condition that can cause many complications sudden death when not appropriately controlled. This study determined serum calcium, parathyroid hormone, vitamin D, renin, angiotensin II, I converting enzyme, aldosterone in hypertensive individuals, as these compounds play key roles regulating human blood pressure. Materials Methods: case-control was conducted on 549 (324 cases 225 controls) individuals between October 2018 September 2020....
Organophosphorus pesticides such as dichlorvos (DDVP) are often employed to eradicate pests, especially in low and medium-income countries. However, they have several negative impacts on the visceral organs. Astonishingly, curcumin protects organs from detrimental effects of xenobiotics via maintenance redox homeostasis; unfortunately, its role dichlorvos-provoked multi-organ impairment vis-à-vis lipid homeostasis has not been examined. Therefore, this undertaking probed remedial efficacy...
Abstract Background Apoptotic evasion is one of the genuine hallmarks cancer and appears to be a critical component most therapeutic options in prostate treatment. Reactive oxygen nitrogen species play role execution apoptosis. Redox antioxidant changes are involved malignant transformation associated with intervention cancer. Method The study population were cancer, benign prostatic hyperplasia subjects age-matched controls (45–85 years). Oxidative stress (OS) markers; Hydrogen peroxide (H...
Background: Nigeria's population continues to grow at a fast rate despite the presumed increase in use of contraceptives.Appropriate strategies and policies that will contribute better coverage may arise from reviewing current trends. Objectives:To determine trend contraceptive among women attending family planning clinics selected facilities southwestern part Nigeria 2007 2017.Methods: This is retrospective study who accessed services primary, secondary, tertiary health care between...
Depo-Provera®; Depot-Medroxyprogesterone Acetate (DMPA) is one of the most used contraceptives and it currently by more than 30 million women in developed developing countries.The study was designed to investigate relationship between serum cortisol risk osteoporosis Nigerians using Depo-Provera®.We investigated 50 Depo-Provera® age-matched control, not on DPMA.Serum cortisol, progesterone, estrogen, estradiol, calcium, cathepsin K urinary excretion rate calcium were determined subjects...
Aim: To evaluate the effects of marijuana and cigarette smoke on serum testosterone level in male smokers. Methods: Testosterone was estimated using enzyme immunoassay micro plate format 30 smokers, 15 smokers 25 sex, age matched non-smokers as controls. Body mass index (BMI) all subjects also calculated. Results: There a significant decrease (P<0.05) (5.33±3.5ng/ml) when compared with (8.5±2.4ng/ml) but showed no difference statistically (P>0.05) (5.4±1.5ng/ml). A...
Background: Irrespective of the cause kidney injury, development renal fibrosis may likely result after prolong insult by etiologic agent. Inflammatory process associated with an increase in number and activity mast cell (MC) has been implicated fibrosis. Renal occurs through activation MC immunoglobulin E (IgE) binding to high-affinity receptor on its surface. After IgE binding, release inflammatory mediators such as histamine, protease, cytokines, chemokines. Aim: This study was designed...
Prostate cancer (PCa) is the most prevalent in Nigerian male population, similar to other black populations. It postulated that exposure endogenous or environmental steroids prompts prostatic mediated changes via steroid receptors as well a decrease androgen/estrogen ratio and aging. Thereby contributing carcinogenesis disease progression. This study aimed determine plasma levels of testosterone, 17β-estradiol pattern expression subjects with prostate cancer, benign hyperplasia, controls....
Current reports show that most of the routinely available prostate specific antigen (PSA) derived biomarkers cancer (PCa) have failed to demonstrate sufficient sensitivity and specificity in clinical use for diagnosis prognosis PCa. Consequently, a number molecular markers including gene 3 (PCA3) are being considered use. This study was therefore designed determine levels PCA3 mRNA expression urine plasma patients assess its diagnostic characteristics Nigerian population with cancer. A total...