A5101794812- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- High Altitude and Hypoxia
- Epigenetics and DNA Methylation
- Connexins and lens biology
- Mitochondrial Function and Pathology
- Extracellular vesicles in disease
- RNA modifications and cancer
- Disaster Response and Management
- Nanoparticle-Based Drug Delivery
- S100 Proteins and Annexins
- Biochemical effects in animals
- Cancer-related Molecular Pathways
- Genomics, phytochemicals, and oxidative stress
- Circular RNAs in diseases
- Calpain Protease Function and Regulation
- Advanced Sensor and Energy Harvesting Materials
- Robotic Path Planning Algorithms
- Pulmonary Hypertension Research and Treatments
- Robotics and Sensor-Based Localization
- Advanced Nanomaterials in Catalysis
- IoT and GPS-based Vehicle Safety Systems
- Neurological Disorders and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
Tianjin University
2019-2025
Wenzhou University
2022
Tianjin Medical University
2018
Logistics University of People's Armed Police Force
2014-2017
Chinese People's Armed Police Force
2010-2014
Chinese People's Armed Police General Hospital
2010-2012
The rapid and timely evaluation of the mental health emergency rescuers can effectively improve quality rescues. However, biosensors for are now facing challenges, such as portable detection multiple biomarkers. In this study, a non-invasive, flexible, wearable electrochemical biosensor was constructed based on self-assembly nanomagnetic beads cortisol in interstitial fluid (ISF) to assess stress rescuers. Based one-step reduction, gold nanoparticles (AuNPs) were functionally modified...
Abstract Robotics have important applications in the field of disaster medical rescue. The deployment urban rescue robots at earthquake site can help shorten response time, improve efficiency and keep personnel away from danger. This discussion introduces performance some actual scenarios, focuses on current research status that provide assistance, analyzes merits shortcomings each system. Based existing studies, limitations development directions are also discussed.
In this work, a novel enzyme-linked immunosorbent assay (ELISA) with low limit of detection and high sensitivity was developed using atom transfer radical polymer (ATRP)-modified gold nanoparticles (AuNPs). Clear signal amplification achieved by introducing an abundance horseradish peroxidase (HRP) to the AuNPs, because ATRP modification. This result suggested that new ELISA able detect antigens in complex mixtures, (LOD) lower than conventional factor 81. The strategy greatly decreased LOD...
Hypoxia-related microRNAs (miRNAs) are involved in the pathogenesis of various diseases. Because potential variations miRNA expression mediated by hypoxic lung injury at high altitude remain incompletely characterized, we used a rat model to investigate biochemical and changes induced high-altitude hypoxia. After 24, 48, or 72 h exposure, VEGF/Notch pathway-related proteins were increased tissues. Microarray screening samples revealed 57 differentially expressed miRNAs, 19 which related...
Abstract Extracellular vesicles (EVs), including exosomes, have inherent homing ability in damage repair and drug delivery. However, they poor targeting low enrichment efficiency are easily internalized/cleared by monocyte phagocyte system. If the of exosomes can be improved through a series means, better use made advantages exosome therapy It is necessary to ensure certain retention rate study signal pathways potential mechanisms, especially flowing blood. This article mainly reviews...
Increased endogenous αB-crystallin protein levels have been shown to reduce cell apoptosis, although the effects of exogenous remain poorly understood. The present study established an acute ocular hypertension model in right eye Sprague-Dawley rats. Fluorogold retrograde tracing and immunofluorescence methods showed that number retinal ganglion cells decreased eyes caspase-3 expression increased following hypertension. Intravitreal injection reduced expression. Results demonstrated...
Objective Pulmonary microvascular endothelial cells (PMECs) exhibit specific responses in adaptation to hypoxia. However, the mechanisms regulating PMEC activities during hypoxia remain unclear. This study investigated potential involvement of a microRNA, miR-375-3p, regulation activities. Methods Primary PMECs were isolated from rats. The expression levels miR-375-3p and Notch1 detected by quantitative PCR western blotting. Luciferase reporter assays performed explore transcriptional...
In the present study, microRNA (miRNA) expression profiles of rats exposed to high altitude hypoxia and normal conditions were obtained from miRNA array analysis. Bioinformatics analyses, including use Gene Oncology Kyoto Encyclopedia Genes Genomes databases, used identify genes pathways, which specifically associated with hypoxic environment‑associated miRNAs. A total 26 miRNAs differentially expressed in two groups, comprising six upregulated 20 downregulated a novel pattern their pathways...
Sulforaphane (SFN) has been demonstrated to exert a protective role in various diseases. However, the of SFN phosgene-induced acute lung injury (P-ALI) remains unclear. This study aimed explore and mechanism P-ALI provide theoretical basis for clinical prevention treatment P-ALI.
Objective As members of CNEDERT, we were trusted to take the mission medical rescue in April this year Yushu area Qinghai province. soon as heard news earthquake with shock 7.1 on Richter scale happened 14th 2010, our team 32 from General Hospital Armed Police Force rapidly rushed get there at 19 o'clock April. It is a cold plateau 4000 meters average above sea level. Of course, they would face many difficult problems and some them could not be figured out advance. was really new big...
Introduction: In recent years, the development of disaster medicine has made rapid progress in China after Wenchuan earthquake 2008. formed a more systematic and specialized health emergency force. addition, Ministry Emergency Management was established 2018, which demonstrated that Chinese government is paying attention to rescue work. this report, practice, experience, prospect reviewed. Aim: To explore current status prospects China. Methods: The literature research method used analyze at...
<abstract abstract-type="Abstract"> <sec> <b>Introduction</b> The swift advancement of biotechnology has presented both opportunities and challenges to our society, thrusting biosafety the forefront concern. Consequently, evaluation rescue capabilities in event a bioterrorism incident becomes paramount importance. Currently, there is notable absence specific measurement criteria comprehensive system. This paper aims establish systematic approach towards assessing emergency response context...
Objective To investigate the protective effect of rosiglitazone on rats with high altitude pulmonary edema. Methods Thirty-six SD were randomly(random number) divided into 6 groups(n=6 each): control group(Control), hypobaric hypoxia model group(HH), groups(RSG)which administered 3 different doses[RSG-L: 5 mg/(kg·d), RSG-M: 10 RSG-H: 20 mg/(kg·d) ], dexamethasone group[Dex, 4 mg/(kg·d)]. Rats injected intraperitoneally doses (RSG), dexamethasone(Dex)or vehicle (Control and HH) for...
Air pollution exposure has been found to be associated with epigenetic modification of the mitochondrial genome, which could subsequently induce adverse health outcomes. However, very limited studies exist regarding association between fine particulate matter (PM2.5) and pulmonary function at molecular level changes. This study aimed investigate platelet DNA (mtDNA) methylation occupational PM2.5 function. First, 768 participants were occupationally exposed polycyclic aromatic hydrocarbon...