A5032858261- Immune cells in cancer
- Immune Response and Inflammation
- Sepsis Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Structural Engineering and Vibration Analysis
- Immune Cell Function and Interaction
- S100 Proteins and Annexins
- Cardiac Fibrosis and Remodeling
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
- Thermodynamic and Exergetic Analyses of Power and Cooling Systems
- Digestive system and related health
- Mosquito-borne diseases and control
- High Altitude and Hypoxia
- Immunotherapy and Immune Responses
- Advanced Biosensing Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Gene Regulatory Network Analysis
- Chemical Reactions and Isotopes
- Genetics, Bioinformatics, and Biomedical Research
- Digital Transformation in Industry
- Biosensors and Analytical Detection
People's Hospital of Cangzhou
2021-2024
Xiamen University
2023-2024
Cloud Computing Center
2021
Chinese People's Armed Police Force
2008-2018
Logistics University of People's Armed Police Force
2014-2018
Baoding University
2018
Chinese People's Armed Police Force Medical College Affiliated Hospital
2008
Xiangya Hospital Central South University
2006
Central South University
2006
The stromal and immune cells that form the tumor microenvironment serve a key role in aggressiveness of tumors. Current tumor‑centric interpretations cancer transcriptome data ignore roles cells. aim present study was to investigate clinical utility tissue‑based data. 'Estimation STromal Immune MAlignant Tumor tissues using Expression data' (ESTIMATE) algorithm used probe diverse datasets fraction scored. association between ESTIMATE scores patient survival asessed; it indicated two have...
Periostin, a multifunctional extracellular protein, plays an important role in inflammatory disorders and tumorigenesis. Our previous work has demonstrated that periostin deficiency inhibits colorectal cancer (CRC) progression. Here, we aim to clarify the of immune microenvironment CRC. We find significantly decreases infiltration programmed death receptor 1 (PD-1)+ tumor-associated macrophages (TAMs) CRC tissues. Periostin promotes expression PD-1 on TAMs by integrin-ILK-nuclear factor κB...
Autoantibodies against tumor antigens are promising means for cancer diagnosis and prognosis. In this study, we applied a proteomic approach to identify proteins that commonly elicit humoral response in lung squamous carcinoma (LSC). Sera from 20 newly diagnosed patients with LSC matched healthy individuals were analyzed antibody-based reactivity separated by two-dimensional electrophoresis. triosephosphate isomerase (Tim) superoxide dismutase [Mn] (MnSOD) detected sera over 20% but none the...
Background: Periostin (POSTN) is a critical extracellular matrix protein in various tumor microenvironments.However, the function of POSTN thyroid cancer progression remains largely unknown.Methods: Postn and Rag1 knock-out mice orthotopic mouse models were used to determine role on papillary progression.Immunofluorescence, cell co-culture, fluorescence situ hybridization, chromatin immunoprecipitation assay, recombinant inhibitor treatment performed explore underlying mechanisms...
In this work, a novel enzyme-linked immunosorbent assay (ELISA) with low limit of detection and high sensitivity was developed using atom transfer radical polymer (ATRP)-modified gold nanoparticles (AuNPs). Clear signal amplification achieved by introducing an abundance horseradish peroxidase (HRP) to the AuNPs, because ATRP modification. This result suggested that new ELISA able detect antigens in complex mixtures, (LOD) lower than conventional factor 81. The strategy greatly decreased LOD...
The physical and virtual access of manufacturing equipment to the cloud platform is an important direction research, but current research results in this are not enough support "landing" wide application model. In traditional model, direct brings huge network pressure unbearable latency, also poses a privacy security risk. Aiming at cloudification environment, 3D printer selected as object, cloud-edge collaboration architecture for printers based on digital twin proposed. To solve lack...
The Connectivity Map (CMap) is a tool that has been extensively utilized to study drug repositioning and side-effect prediction. However, most of these analyses rely on signature genes, ignoring the pathways by which those genes are regulated, as well functional overlap redundant genes. present systems biology approach referred Weighted Gene Co-expression Network Analysis (WGCNA) dissect transcriptional profiles CMap reveal hidden factors. Seven common modules associated with protein...
Severe trauma and burns accompanied by sepsis are associated with high morbidity mortality. Little is known about the transcriptional similarity between trauma, burns, sepsis, systemic inflammatory response syndrome (SIRS). Uncovering key genes molecular networks critical to understanding biology of disease. Conventional analysis gene changes (fold change) difficult for time-serial data such as post-injury blood transcriptome.Weighted co-expression network (WGCNA) was applied dataset...
High-grade serous ovarian cancer (HGSOC) is an aggressive disease that largely resistant to today's immunotherapies. Here, we aimed investigate the prognostic significance of CTLA4, PD-1, and T-cell activation status in HGSOC.Using a publicly accessed microarray dataset including 260 HGSOC samples, calculated Kaplan-Meier survival curves for overall (OS), evaluated associations with multivariate Cox regression models evaluate associations, summarized using hazard ratio (HR). The correlations...
Abstract Background Immune dysregulation is a feature of sepsis. However, comprehensive analysis the immune landscapes in septic patients has not been conducted. Objectives This study aims to explore abundance ratios cells sepsis and investigate their clinical value. Methods Sepsis transcriptome data sets were downloaded from NCBI GEO database. The immunedeconv R package was employed analyze calculate different cell types. Differential performed using t test. Spearman rank correlation...
Because of tumour dependence on angiogenesis, anti-angiogenic therapy has become the most attractive area basic and clinical study in field cancer research. In order to create a synergistic effect angiogenesis immune regulation, we designed constructed new type DNA vaccine that can express VEGFR2 (vascular endothelial growth factor receptor 2) prostate antigen IL-12 (interleukin 12) same reading frame. The aim this was investigate anti-tumour activity eukaryotic expression plasmid carrying...
In the present study, microRNA (miRNA) expression profiles of rats exposed to high altitude hypoxia and normal conditions were obtained from miRNA array analysis. Bioinformatics analyses, including use Gene Oncology Kyoto Encyclopedia Genes Genomes databases, used identify genes pathways, which specifically associated with hypoxic environment‑associated miRNAs. A total 26 miRNAs differentially expressed in two groups, comprising six upregulated 20 downregulated a novel pattern their pathways...
Abstract High-grade serous ovarian cancer (HGSOC) is an aggressive disease known to develop resistance chemotherapy. We investigated the prognostic significance of tumor cell states and potential mechanisms underlying chemotherapy in HGSOC. Transcriptome deconvolution was performed address cellular heterogeneity. Kaplan–Meier survival curves were plotted illustrate outcomes patients with varying abundances. The association between gene expression response tested. After adjusting for surgery...
Sepsis, a systemic inflammatory response caused by infection, can lead to sepsis-associated encephalopathy (SAE), characterized brain dysfunction without direct central nervous system infection. The pathogenesis of SAE involves blood-brain barrier disruption, neuroinflammation and neuronal death, with being the core process. Nogo-A, neurite growth-inhibitory protein in system, is not well understood sepsis. This study explores Nogo-A's mechanisms sepsis, focusing on SAE. Using vivo vitro...
Segmental assembled box girder has the characteristics of fast construction progress, small environmental interference, industrialized construction, and reduction life cycle cost. The rigid structure system advantages no bearing, good seismic performance, easy maintenance. segmental takes into account above advantages. However, reasonable application this type bridge lacks detailed research. Taking ji-he reconstruction expansion project as background project, closely following prefabricated...
Objective To investigate the protective effect of rosiglitazone on rats with high altitude pulmonary edema. Methods Thirty-six SD were randomly(random number) divided into 6 groups(n=6 each): control group(Control), hypobaric hypoxia model group(HH), groups(RSG)which administered 3 different doses[RSG-L: 5 mg/(kg·d), RSG-M: 10 RSG-H: 20 mg/(kg·d) ], dexamethasone group[Dex, 4 mg/(kg·d)]. Rats injected intraperitoneally doses (RSG), dexamethasone(Dex)or vehicle (Control and HH) for...
Five different (NH 3 /CO 2 , R22/CO R32/CO R290/CO R404a/CO ) cascade refrigeration cycles are analyzed.It shows that at given condition, the NH cycle has maximum COP, COP of and is almost same, five increased with evaporating temperatures t 1 rise, while it decreased heat-transfer temperature difference condenser-evaporator Δt condensing LTC except have a best 7 minimum when less than -10˚C, but same as 0˚C.