A5101958375- Cancer, Hypoxia, and Metabolism
- Fibroblast Growth Factor Research
- Renal cell carcinoma treatment
- Peroxisome Proliferator-Activated Receptors
- Medical Imaging and Pathology Studies
- Renal and related cancers
- Ocular Oncology and Treatments
- Neuropeptides and Animal Physiology
- Epigenetics and DNA Methylation
- Genetic and Kidney Cyst Diseases
- Attention Deficit Hyperactivity Disorder
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Signaling Pathways in Disease
- Diatoms and Algae Research
- Sarcoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Acute Myeloid Leukemia Research
- Glioma Diagnosis and Treatment
- Cancer-related Molecular Pathways
National Institutes of Health
2007-2022
George Washington University
2008-2022
National Institute of Neurological Disorders and Stroke
2008-2022
The Ohio State University Wexner Medical Center
2014
National Human Genome Research Institute
2010
There is increasing evidence that suggests knockout of tumor-suppressor gene function causes developmental arrest and protraction cellular differentiation. In the peripheral nervous system patients with disorder, von Hippel–Lindau disease, we have demonstrated developmentally arrested structural elements composed hemangioblast progenitor cells. Some progress to a frank tumor, hemangioblastoma. However, in hemangioblastomas are frequently observed cerebellum, suggesting an origin central...
von Hippel-Lindau disease (VHL) patients develop highly vascular tumors, including central nervous system hemangioblastomas. It has been hypothesized that the nature of these tumors is product reactive angiogenesis. However, recent data indicate VHL-associated hemangioblastoma neoplastic cells originate from embryologically-arrested hemangioblasts capable blood and endothelial cell differentiation. To determine origin tumor vasculature in hemangioblastomas, we analyzed elements VHL patients....
Inactivation of the von Hippel-Lindau (VHL) gene and activation hypoxia-inducible factor (HIF) in susceptible cells precedes formation tumorlets frank tumor epididymis male VHL patients. We performed detailed histologic molecular pathologic analysis tumor-free epididymal tissues from patients to obtain further insight into early tumorigenesis. Four epididymides two were serially sectioned allow for three-dimensional visualization morphologic changes. Areas interest genetically analyzed by...
Abstract von Hippel-Lindau (VHL) disease is an autosomal dominant hereditary cancer disorder caused by a germline mutation in the VHL tumor suppressor gene. Loss of wild-type allele results deficiency and potential formation cerebellar hemangioblastomas, which resemble embryonic hemangioblast proliferation differentiation processes. Multiple, microscopic, VHL-deficient precursors, termed developmentally arrested structural elements (DASEs), consistently involve molecular layer patients,...
Renal clear cell carcinoma commonly occurs in patients with von Hippel‑Lindau disease (VHL). Kidneys of VHL (VHL kidneys) contain an abundance independent proliferation events that have been hypothesized to represent precursor structures carcinoma. In the present study, it was tried identify site origin proliferation, and immunophenotype cells. Using 3D histological tracking, topographic microscopic investigated by identification informative interest immunohistochemical staining for cluster...
Background and Objectives: This study aims to describe the earliest renal lesions in patients with von Hippel-Lindau (VHL) disease, especially multicellular microscopic pathologic events, get information into genesis of neoplasms this condition. Materials Methods: Multicellular events were identified, 3dimensional reconstruction was performed grossly normal kidney parenchyma from VHL disease by using H&E-stained slides previously prepared. Results: The measured volume clusters...
BACKGROUND: Emerging data indicate that von Hippel-Lindau disease (VHL) associated tumors arise from embryologic hemangioblasts can form vessels (endothelial cells) and blood cells. Nevertheless, the origin of VHL-associated vasculature is not known. To determine tumor vasculature, we investigated neoplastic VHL patients. METHODS: Microdissected (compared to control non-VHL tissues) vascular features were examined using immunohistochemical staining for CA9, HIF-2a, HIF-1a, CD31 Factor VIIIa....