A5081288629- Sinusitis and nasal conditions
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Peptidase Inhibition and Analysis
- Pediatric health and respiratory diseases
- interferon and immune responses
- Infectious Diseases and Mycology
- Cancer Research and Treatments
- Immune Response and Inflammation
- Ubiquitin and proteasome pathways
- Cytokine Signaling Pathways and Interactions
- Moringa oleifera research and applications
- IL-33, ST2, and ILC Pathways
- Gut microbiota and health
- RNA Interference and Gene Delivery
- ATP Synthase and ATPases Research
- Lung Cancer Research Studies
- Biomarkers in Disease Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Esophageal and GI Pathology
- Respiratory and Cough-Related Research
- Advanced Chemical Sensor Technologies
- Cancer-related gene regulation
- Dermatology and Skin Diseases
- MicroRNA in disease regulation
Nanchang University
2017-2024
First Affiliated Hospital of Jiangxi Medical College
2024
First Affiliated Hospital of Nanchang University
2017-2023
Jiangxi Provincial Institute of Water Sciences
2023
Abstract The development and progression of gastric cancer (GC) is greatly influenced by microbiota their metabolites. Here, we characterized the microbiome metabolome profiles 37 GC tumor tissues matched non-tumor using 16s rRNA gene sequencing ultrahigh performance liquid chromatography tandem mass spectrometry, respectively. Microbial diversity richness were higher in than tissues. abundance Helicobacter was increased tissues, while Lactobacillus , Streptococcus Bacteroides Prevotella 6...
Metastatic lung cancer is a life-threatening condition that develops when in another area of the body metastasizes, or spreads, to lung. Despite advances our understanding primary oncogenesis, biological basis driving progression from metastatic remains poorly characterized. Genetic knockdown particular genes cells were achieved by lentiviral-mediated interference. Invasion potential was determined Matrigel and three-dimensional invasion. The secretion matrix metalloproteinase 2 (MMP2) MMP9...
Hypoxia is involved in inflammation and immune response; however, its role the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) not fully understood. We aimed to investigate mechanisms by which hypoxia disrupts epithelial barrier CRSwNP. The expression hypoxia-inducible factor-1α (HIF-1α), protein tyrosine phosphatase non-receptor type 2 (PTPN2), tight junction (TJ) components (claudin-4, occludin, ZO-1) was detected using immunohistochemistry, western blotting, qRT-PCR....
Introduction: Chronic rhinosinusitis (CRS) is often classified primarily on the basis of absence or presence nasal polyps (NPs), that is, as CRS with (CRSwNP) without (CRSsNP). Additionally, according to percentage eosinophils, CRSwNP can be further divided into eosinophilic (ECRSwNP) and non-ECRSwNP. a significant public health problem considerable socioeconomic burden. Previous research reported pathophysiology complex, multifactorial disease. There have been many studies its etiology, but...
Background The pathogenesis of chronic rhinosinusitis (CRS) is not yet clear. microRNAs are widely involved in a number physiological and pathological processes, which microRNA-146a (miR-146a) plays an important role innate immunity, inflammatory response, other pathophysiological processes. Mucins (MUCs) components secreted mucus, MUC5AC the major MUC normal airway. Objective This study was performed to examine human neutrophil elastase (HNE)-induced overexpression CRS via miR-146a. Methods...
Nitric oxide (NO) is an important messenger molecule widely present in the human body. However, role of nasal NO (nNO) eosinophilic chronic rhinosinusitis with polyps (Eos CRSwNP) remain unclear. This study aimed to investigate diagnostic value and underlying mechanism nNO Eos CRSwNP.The medical records 84 non-Eos CRSwNP patients, 55 37 control subjects were retrospectively reviewed. The for was assessed. expression inducible nitric synthase (iNOS), endothelial (eNOS), tight junctions (TJs)...
GPX4 has attracted much attention as a key molecule of cell ferroptosis, but its role in apoptosis is rarely reported, and thyroid cancer (TC) not been reported. The analysis TCGA database showed that both FKBP8 were highly expressed TC tumor tissues; expression positively correlated. immunohistochemical further confirmed tissues. In addition, the high significantly correlated with poor prognosis TC. Silencing inhibited proliferation, induced cells, reduced growth mice....
Abstract Tripartite Motif 14 (TRIM14) is an oncoprotein that belongs to the E3 ligase TRIM family, which involved in progression of various tumors except for non-small cell lung carcinoma (NSCLC). However, little currently known regarding function and related mechanisms TRIM14 NSCLC. Here, we found protein was downregulated adenocarcinoma tissues compared with adjacent tissues, can suppress tumor proliferation migration both vitro vivo. Moreover, directly bind glutamine fructose-6-phosphate...
Background: Specific immunotherapy is an important immune-modifying treatment for patients with allergic rhinitis (AR). We compared the early efficacy and safety of cluster conventional immunotherapies AR. Methods: One hundred forty-nine persistent AR were enrolled in a randomized open-label trial divided into following 4 groups: 60 children treated conventionally, 33 using schedule, 23 adults schedule. Patients groups reached maintenance dose within 6 weeks, while those receiving therapy 14...
BACKGROUND: Sinonasal mucosal melanoma (SNMM) is a lethal malignancy with poor prognosis. Treatment outcomes of SNMM are poor. Novel prognostic or progression markers needed to help adjust therapy. METHODS: RNA-seq was used analyze the mRNA expression tumor tissues and normal nasal mucosa from primary patients (n= 3). Real-time fluorescent quantitative PCR (qRT-PCR) validate results 3), while protein analyzed by immunohistochemistry (IHC, n= 31) western blotting Retrospective studies were...
Chronic rhinosinusitis (CRS) is a heterogeneous disease. The pathogenesis of chronic sinusitis still unclear; however, the nasal cavity and paranasal sinuses are commonly affected by type 2 inflammation, which caused Th2 cytokines such as interleukin (IL)-5, IL-4, IL-13. Previous studies have shown that pendrin promotes local infiltration neutrophils through production human neutrophil elastase (HNE), essential for secretion mucin 5AC (MUC5AC) in inflammatory diseases lower respiratory...
Objective: The efficacy of anlotinib as a treatment for head-and-neck squamous cell carcinoma (HNSCC) has been little explored. Here, we used patient-derived xenografts (PDXs) to this end. Methods: Fresh tumor tissues HNSCC patients were screened in terms vitro drug sensitivity using the MTT assay. Patient PDXs confirm anti-tumor effects vivo. After medication regimen was complete, volume changes mice calculated. Apoptosis measured TUNEL proliferation and apoptosis levels yielded data on...
Objective:To investigate the expression of growth factor differentiation 15 (GDF15) in nasal mucosa patients with chronic rhinosinusitis (CRS) and its relationship mucin 5AC(MUC5AC).Method:Fifteen CRS polyps, without polyps normal were enrolled study. Hisological changes sinonasal examined by hematoxylin eosin (HE) stainding. The total mucins was evaluated periodic acid Schiff staining(PAS). And GDF15 MUC5AC measured immunohistochemistry (IHC), reverse transcription polymerase chain reaction...
Objective:To investigate the expression of microtubuleassociated protein 1 light chain 3 beta(LC3) and eosinophil cationic in allergic rhinitis(AR) for further understanding pathogenesis AR. Method: Twenty cases normal nasal mucosa 20 AR were collected. Histological changes examined by hematoxylin eosin(HE) staining. The LC3 ECP measured immunohistochemistry(IHC) Western Blot(WB). Result: tissue samples demonstrated a large number eosinophils lymphocytes infiltration IHC revealed that...
Objectives: To determine the efficacy and safety of a novel bougie for removal esophageal coins lodged in proximal esophagus. Subjects Methods: This was an observational study. Medical records were reviewed patients who confirmed with between July 2015 October 2016 our department. Sixty-three patients, upper by radiographs, treated using this to remove coins. Results: A total 63 children enrolled Sixty (95%) removed successfully. The coin extracted on first attempt 56 cases (89%), second 3...
Allergic rhinitis (AR) is characterized by an inflammatory reaction. High mobility group box 1 (HMGB1) protein and interleukin (IL)-33 are damage-associated molecular pattern molecules have many characteristics similar to pro-inflammatory cytokines. However, the role of IL-33 HMGB1 in AR remains unclear. The aim this study explore AR.Twenty patients with (AR group) 10 normal controls (normal were enrolled study. expression analyzed immunohistochemistry epithelial cells inferior turbinate...
Objective: To study the effect of trefoil factor family (TFF) 3 on expression tight junctions (TJs) in nasal mucosa epithelium eosinophilic chronic rhinosinusitis (eCRS) and its mechanism. Methods: From September to December 2020, eligible patients from Department Otorhinolaryngology First Affiliated Hospital Nanchang University were recruited, including 11 control 37 with polyps (CRSwNP), whom polyp tissue samples collected. Immunohistochemistry (IHC) was used detect localization intensity...
The recognition of bitterness as a defense mechanism helps animals avoid the intake toxic substances. bitter taste receptor is an G protein coupled 7 transmembrane (GPCR), receptor(TAS2R) not only express in oral buds, but also expressing other tissues, such stomach, pancreas, duodenum, brain, heart, kidney, omental artery, testis, lung, nasal cavity. This article reviews research on respiratory system. Key words: Taste; TAS2R; upper respiratory; Asthma
Objective: To check Forkhead box M1 (FoxM1) expression in nasal mucosal of chronic rhinosinusitis (CRS) patients and the effect inflammatory factors on FoxM1 expression, order to research significance CRS. Methods: From January October 2018, 50 hospitalized Department Otorhinolaryngology, Head Neck Surgery, First Affiliated Hospital Nanchang University were enrolled this study. Twenty CRS with polyps (CRSwNP), 20 without (CRSsNP) 10 simple deviation septum (the control groups) selected. The...