A5003010875- Atrial Fibrillation Management and Outcomes
- Cardiovascular Disease and Adiposity
- Cardiac Arrhythmias and Treatments
- COVID-19 Clinical Research Studies
- Apelin-related biomedical research
- Biomarkers in Disease Mechanisms
- Galectins and Cancer Biology
- Kawasaki Disease and Coronary Complications
- Potassium and Related Disorders
- Cardiovascular Function and Risk Factors
- Coronary Artery Anomalies
- Cardiac Imaging and Diagnostics
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Systemic Lupus Erythematosus Research
- Cardiovascular Syncope and Autonomic Disorders
- Coronary Interventions and Diagnostics
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Acute Myocardial Infarction Research
- Cerebrovascular and genetic disorders
- Inflammatory Bowel Disease
- Aortic aneurysm repair treatments
Istanbul Medeniyet University
2016-2024
Istanbul Eye Hospital
2023
Medeniyet Üniversitesi Göztepe Eğitim ve Araştırma Hastanesi
2021
Anadolu University
2021
Ghent University
2020
European Society of Cardiology
2020
Istinye University
2014-2017
Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi
2013-2015
Adherence to non-vitamin K antagonist oral anticoagulants (NOACs) is an important factor for ensuring efficacy and safety in nonvalvular atrial fibrillation (NVAF). There are controversial results regarding NOAC adherence real-world data there no about Turkish population. This study investigated the based on self-report, factors affecting nonadherence, relation of level with outcomes. multicenter cross-sectional included 2738 patients (59% female) using (dabigatran, apixaban, rivaroxaban)...
The current knowledge about novel coronavirus-2019 (COVID-19) indicates that the immune system and inflammatory response play a crucial role in severity prognosis of disease. In this study, we aimed to investigate prognostic value systemic biomarkers including C-reactive protein/albumin ratio (CAR), nutritional index (PNI), neutrophil-to-lymphocyte (NLR), lymphocyte-to-monocyte (LMR), platelet-to-lymphocyte (PLR) patients with severe COVID-19.This single-center, retrospective study included...
Coronavirus disease-19 (COVID-19) is a multisystemic disease that can cause severe illness and mortality by exacerbating symptoms such as thrombosis, fibrinolysis, inflammation. Plasminogen activator inhibitor-1 (PAI-1) plays an important role in regulating fibrinolysis may thrombotic events to develop. The goal of this study examine the relationship between PAI-1 levels severity relation COVID-19.A total 71 hospitalized patients were diagnosed with COVID-19 using real time-polymerase chain...
A systemic inflammatory reaction is a common feature of both sarcoidosis and atherosclerosis. Endothelial-cell specific molecule 1 (endocan) marker vascular pathology which also shows correlation with inflammation, endothelial dysfunction, The objective this study was to evaluate the involvement in using serum endocan levels brachial artery flow-mediated dilation (FMD), dysfunction. We included 53 patients without conventional cardiovascular risk factors 40 healthy controls. Endothelial...
The risk for cardiovascular diseases and type 2 diabetes mellitus significantly increases in the patient population with metabolic syndrome (MeS). present study aimed to investigate association between epicardial adipose tissue thickness (EATT) oxidative stress parameters MeS patients. included 181 patients as a group of 92 consecutive control 89 similar age gender. EATT was evaluated by transthoracic echocardiography. Serum levels total oxidant status (TOS), antioxidative capacity (TAS),...
In this study, it was aimed to investigate the relationship between epicardial adipose tissue thickness (EATT) and serum IL-17A level insulin resistance in metabolic syndrome patients. This study enrolled a total of 160 subjects, whom 80 were consecutive patients who applied our outpatient clinic diagnosed with syndrome, other part control group similar age demographics excluded. The diagnosis made according International Diabetes Federation (IDF)-2005 criteria. EATT measured transthoracic...
Background: The time in therapeutic range values may vary between different geographical regions of Turkey patients vitamin K antagonist therapy.Aims: To evaluate the percentages, efficacy, safety and awareness warfarin according to who participated WARFARIN-TR study (The Awareness, Efficacy, Safety Time Therapeutic Range Warfarin Turkish population) Turkey.Study Design: Cross-sectional study. Methods:The includes 4987 using involved regular international normalized ratio monitoring January...
Background: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia worldwide and associated with an increased risk of thromboembolism, ischemic stroke, impaired quality life, mortality.The latest research that shows prevalence incidence AF patients in Türkiye was Turkish Adults' Heart Disease Risk Factors study, which included 3,450 collected data until 2006/07.The Real Life Fibrillation Clinical Practice (TRAFFIC) study planned to present current data, reveal reflection new...
The objective of this study was to evaluate the serum levels ischemia modified albumin and oxidative stress parameters in patients with cardiac syndrome X.A total 61 patients, composed 32 consecutive (24 female, 8 male, average age: 47.63 +/- 9.49 years) diagnosed X by coronary angiography (initially performed following identification exercise test or myocardial perfusion scintigraphy) a control group 29 (15 14 49.59 11.68 similar features without were included study. (IMA), ferric reducing...
As the Modified Anticoagulation and Risk Factors in Atrial Fibrillation Score (M-ATRIA-RS) encompasses prognostic risk factors of novel coronavirus-2019 (COVID-19), it may be used to predict in-hospital mortality. We aimed investigate whether M-ATRIA-RS was an independent predictor mortality patients hospitalized for COVID-19 compare its discrimination capability with CHADS, CHA2DS2-VASc, modified CHA2DS2-VASc (mCHA2DS2-VASc)-RS.A total 1,001 were retrospectively analyzed classified into...
We compared Turkish patients with cardiac syndrome X (CSX) and controls respect to serum pro- anti-inflammatory cytokine levels, as well the single-nucleotide polymorphisms located in promoter regions of their related genes. This study included 111 consecutive angiographically diagnosed CSX healthy similar demographic characteristics. Serum interleukin (IL) 6, tumor necrosis factor α (TNF-α), IL-10 levels were measured, genotypes determined using standard methods. IL-6 significantly higher...
The aim of this study was to evaluate the serum soluble CD40 ligand (sCD40L) levels, uroten- sin II and leptin levels as an indirect indicator endothelial dysfunction, inflammation, atherosclerosis at microvascular level, comparison those values with control group a nor- mal coronary flow pattern.The included 35 consecutive patients (17 women, 18 men; average age: 51.20 ± 10.93 years) in our hospital who underwent angiography due objective myocardial ischemia whom slow detected. 34 normal...
This study aimed to evaluate the serum gamma-glutamyltransferase (GGT) levels as an indirect marker of elevated oxidative stress in patients with dilated ascending aorta.The was designed observational cross-sectional controlled study. One hundred consecutive aorta and 50 controls normal diameter were selected for by comprehensive transthoracic echocardiography (TTE). The aortic dilatation group divided into two subgroups, according literature ectasia (3.8-4.3 cm, 53 patients, 24 male 29...
Although the underlying mechanism is not yet fully understood, Cardiac Syndrome X (CSX) defined as microvascular dysfunction. Prolidase plays a role in collagen synthesis. Increased serum prolidase activity (SPA) has been shown to correlate with turnover. Augmented turn-over may be associated vascular fibrosis and In this study, we assessed whether there was correlation between CXS activity.This case-control study included 45 consecutive CSX patients (mean age 50.7±6.5 years, 27 women) 40...
Coronary microvascular dysfunction is present in large percentage of the population, and it has been shown to have a pathological prognostic role many conditions. Therefore, early detection important, especially selected populations. The aim this study was investigate association galanin with coronary flow reserve (CFR) prehypertensive individuals determine whether can be used as marker detect dysfunction.
BACKGROUND Coronary artery ectasia (CAE) is a well-recognised disorder characterised by abnormal dilation of the coronary arteries. Underlying mechanisms associated with luminal in CAE remain to be elucidated. However, histopathological features resemble those atherosclerosis. Galectin-3 (Gal-3) valuable biomarker for both progression and destabilisation atherosclerotic lesions. To best our knowledge, there no study literature examining serum Gal-3 levels patients isolated CAE. In present...
Abstract Purpose: In this study, we aimed to investigate the relationship between high triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio and coronary slow-flow phenomenon (CSFP) in patients undergoing elective angiography for suspected artery disease. Methods: This prospective study included a total of 84 CSFP 83 controls with normal flow, as evidenced by angiography. The Thrombolysis Myocardial Infarction (TIMI) frame count (TFC) was used measure blood flow velocity....
Abstract Cardiac complications such as heart failure and arrhythmias caused by "iron-induced" cardiomyopathy are considered the primary cause of death in patients with β-thalassemia major. The aim this study was to evaluate electrocardiography, echocardiography according cardiac T2* ferritin findings followed-up for major, investigate importance these early detection complications. included 41 25 healthy individuals matched age gender. results revealed a iron load below 20 msec 12 (29.27%)...